Carbon quantum dots (CQDs, C-dots or CDs), which are generally small carbon nanoparticles (less than 10 nm in size) with various unique properties, have found wide use in more and more fields during the last few years. In this feature article, we describe the recent progress in the field of CQDs, focusing on their synthetic methods, size control, modification strategies, photoelectric properties, luminescent mechanism, and applications in biomedicine, optronics, catalysis and sensor issues.
We report the design of a phosphorescence/fluorescence dual-emissive nanoscale metal–organic framework (NMOF), R-UiO, as an intracellular oxygen (O2) sensor. R-UiO contains a Pt(II)-porphyrin ligand as an O2-sensitive probe and a Rhodamine-B isothiocyanate ligand as an O2-insensitive reference probe. It exhibits good crystallinity, high stability, and excellent ratiometric luminescence response to O2 partial pressure. In vitro experiments confirmed the applicability of R-UiO as an intracellular O2 biosensor. This work is the first report of a NMOF-based intracellular oxygen sensor and should inspire the design of ratiometric NMOF sensors for other important analytes in biological systems.
It is of great significance to develop anticancer therapeutic agents or technologies with high degree of specificity and patient compliance, while low toxicity. The emerging photothermal therapy (PTT) has become a new and powerful therapeutic technology due to its noninvasiveness, high specificity, low side effects to normal tissues and strong anticancer efficacy. Noble metal nanomaterials possess strong surface plasmon resonance (SPR) effect and synthetic tunability, which make them facile and effective PTT agents with superior optical and photothermal characteristics, such as high absorption cross‐section, incomparable optical‐thermal conversion efficiency in the near infrared (NIR) region, as well as the potential of bioimaging. By incorporating with various functional reagents such as antibodies, peptides, biocompatible polymers, chemo‐drug and immune factors, noble metal nanomaterials have presented strong potential in multifunctional cancer therapy. Herein, the recent development regarding the application of noble metal nanomaterials for NIR‐triggered PTT in cancer treatment is summarized. A variety of studies with good therapeutic effects against cancer from impressive photothermal efficacy of noble metal nanomaterials are concluded. Intelligent nanoplatforms through ingenious fabrication showing potential of multifunctional PTT, combined with chemo‐therapy, immunotherapy, photodynamic therapy (PDT), as well as simultaneous imaging modality are also demonstrated.
Even after several years of research, controlled synthesis of photoluminescent carbon nanodots (C-dots) still constitutes a major challenge, and investigation of their photoluminescence (PL) mechanism remains elusive. Various top-down and bottom-up approaches have been reported lately. However, these methods usually suffer from limited control over the major factors that dictate the PL behaviour of these fascinating carbon materials. To this end, we discover a new approach to prepare C-dots from size-tunable single chain polymeric nanoparticles. Taking advantage of the state of the art living radical polymerization technique and unique features of Bergman cyclization, narrowly dispersed C-dots are prepared in a straightforward manner. PL study shows that the optimal emission wavelength of C-dots red-shifts when the size of C-dots decreases, which is different from the trends typically found in semiconductor quantum dots and C-dots prepared from graphitized materials. To clarify the PL mechanism of C-dots prepared from different sources, a theoretical study based on density functional theory is performed. Two series of model compounds, fused aromatic rings and cyclo-1,4-naphthylenes, are chosen for C-dots with different microstructures. The calculation data indicate that PL energy of C-dots is dictated by the size and microstructure of the sp 2 carbon core. For a C-dot with a graphitized core, the smaller the size of the core, the higher the PL energy, while for a C-dot with an amorphous core, an inverse trend is revealed. Surface reduction experiments further show that the quantum yield of C-dots is controlled by the surface chemistry.
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