Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease

Abstract

Vitamin D supplementation normalized Klotho and sclerostin in children with mild to moderate CKD but further increased FGF23 in advanced CKD.

Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease

“…The dosing simulations are in agreement with the results of a systematic review of individuals ≥10 years, which demonstrated that body weight is a significant predictor of change in 25(OH)D concentrations in individuals on vitamin D supplementation 15 . This is further supported by a study in children with CKD, which demonstrated a significant positive association between dose per m 2 body surface area per day and the change in 25(OH)D concentrations 42 . Our simulations illustrate that while there is a large between‐subject variation in dose–response, the therapeutic window of 30–48 ng/mL allows us to propose a practical dosing strategy for use in clinical practice.…”

“… 15 This is further supported by a study in children with CKD, which demonstrated a significant positive association between dose per m 2 body surface area per day and the change in 25(OH)D concentrations. 42 Our simulations illustrate that while there is a large between‐subject variation in dose–response, the therapeutic window of 30–48 ng/mL allows us to propose a practical dosing strategy for use in clinical practice.…”

The effect of vitamin D supplementation on fibroblast growth factor‐23 in patients with chronic kidney disease: A systematic review and meta‐analysis

“…After full‐text examination, 36 publications were excluded for the following reasons: none‐randomized controlled trials (n = 8) (Alshayeb, Josephson, & Sprague, 2013; Block, 2011; Brandenburg & Kruger, 2014; Cozzolino et al, 2009; Donate‐Correa et al, 2014; Fish & Cunningham, 2012; Galassi et al, 2017; Hamano, 2018), RCTs conducted on participants younger than 18 years (n = 1) (Lerch et al, 2018), trials conducted on patients who did not have CKD (n = 6) (Burnett‐Bowie et al, 2012; Cheng et al, 2018; Macdonald et al, 2013; Mesinovic et al, 2019; Trummer et al, 2019; Uzum et al, 2010), non‐experimental studies (n = 1) (Saki, Ranjbar Omrani, & Koohpeyma, 2019), vitamin D supplementation was combined with other treatments (n = 2) (Wetmore, Liu, Krebill, Menard, & Quarles, 2010a; Wetmore, Liu, Krebill, Menard, & Quarles, 2010b), studies without suitable group for vitamin D administration (n = 10) (Albuquerque et al, 2018; Alshayeb et al, 2014; Batacchi et al, 2017b; Bleskestad, Bergrem, Hartmann, Godang, & Goransson, 2012; Cozzolino et al, 2014; Hansen, 2011; Hansen et al, 2011; Hansen, Rasmussen, Pedersen, Rasmussen, & Brandi, 2012; Hansen, Rasmussen, Rasmussen, Bruunsgaard, & Brandi, 2014; Sprague et al, 2015), lack of control group (n = 5) (Cancela et al, 2011; Chitalia et al, 2014; De Niet et al, 2018; Garcia‐Lopes et al, 2012; Zelnick, de Boer, Kestenbaum, Chonchol, & Kendrick, 2018), vitamin D administered via injection (n = 1) (Zhang et al, 2017), and insufficient data reported in the manuscript (n = 2) (Alvarez et al, 2013; Carvalho et al, 2017). Two additional studies were extracted during the full‐text evaluation by hand‐searching the reference lists of related articles, reviews, and meta‐analyses.…”

“…After full-text examination, 36 publications were excluded for the following reasons: none-randomized controlled trials (n = 8) (Alshayeb, Josephson, & Sprague, 2013;Block, 2011;Brandenburg & Kruger, 2014;Cozzolino et al, 2009;Donate-Correa et al, 2014;Fish & Cunningham, 2012;Galassi et al, 2017;Hamano, 2018), RCTs conducted on participants younger than 18 years (n = 1) (Lerch et al, 2018)…”

>b<Tecnologias aplicadas à identificação do papel dos lipídios durante a organogênese em mamíferos (modelos suíno e canino)>/b<

“…Os cães apresentam entre 319 e 321 ossos enlaçados estrategicamente em uma armação denominada esqueleto ósseo que dá suporte ao corpo(DYCE et al, 2004). Funcionalmente, estão associados ao suporte de tecidos moles como principal função, enquanto vinculam-se com a coordenação dos movimentos voluntários, além de possuir uma função protetora outorgada pela conformação da caixa craniana, da caixa torácica e da proteção do tecido mieloide(DYCE et al,2004; CASTRO, 2008) A avaliação da idade esquelética é essencial para o estudo da antropologia(BOUZOUGGAR, et al, 2018), da medicina forense(NEMSI et al, 2018) e da pediatria(LERCH et al, 2018). Além disso é importante para a descrição de doenças associadas aos defeitos do desenvolvimento dos ossos tais como: querubismo (erro no desenvolvimento dos maxilares)(MASSIGNAN, 2001), raquitismo e osteomalácia (defeitos da mineralização óssea)(MECHICA, 1999), entre outras.…”