Validated chromatographic method for the simultaneous determination of eight drugs (morphine, ropivacaine, bupivacaine, baclofen, clonidine, sufentanil, fentanyl and ziconotide) for intrathecal analgesia

Sorrieul, Jérémy; Robert, J.; Gibory, Vincent; Collet, M.; Boutet, M.; Kieffer, Hélène; Folliard, Caroline; Dupoiron, Denis; Devys, Catherine

doi:10.1016/j.pharma.2018.01.006

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Bodor GS [ 33 ] used LC–MS to quantify 43 chemical components commonly found in clinical urine, such as anesthetic analgesics, benzodiazepines and other abused drugs. Sorrieul J et al [ 34 ] established a chromatographic method for simultaneous determination of intrathecal analgesics (morphine, ropivacaine, bupivacaine, baclofen, clonidine, sufentanil, fentanyl and ziconotide) according to the international ICH guidelines, and successfully applied it to quality control before the clinical use of PIVAS laminar flow table dispensing infusion. Jutras M [ 35 ] et al adopted the LC–MS method with positive spray ionization and multireaction monitoring mode to qualitatively identify and quantitatively determine the principal components and metabolites of morphine hydromorphone, fentanyl, midazolam, and propofol in serum samples, and applied this method to the therapeutic drug monitoring of plasma samples from patients in intensive care units of several Canadian hospitals.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous determination of 14 analgesics in postoperative analgesic solution by HPLC–DAD and LC–MS/MS

Yao,

Fang,

Yang

et al. 2024

BMC Chemistry

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A green, efficient, sensitive and accurate detection method by HPLC–DAD and LC–MS/MS was developed and validated for the quantification of morphine, hydromorphone, oxycodone, ketamine tramadol, dezocine, ropivacaine, remifentanil, butorphanol, bupivacaine, droperidol, fentanyl, lornoxicam and sufentanil. The 14 mixtures were chromatographed via HPLC–DAD method which employed 0.05 mol/L potassium dihydrogen phosphate solution-acetonitrile as the mobile phase, the analytes were gradient elution on a SinoChrom ODS-BP C18 column with a total separation time of 35 min, and 14 mixtures showed a good linear relationship in the linear range. The Limit of Quantitation (LOQ) ranged from 0.10 to 20.0 µg/mL, the inter-day and intra-day precision of each analyte is within 1.1–2.0% and 0.4–1.3%, and the average absolute recovery of all compounds was above 98%. The LC–MS/MS method was used to successfully separate the 14 mixtures within 10 min which employed 0.1% formic acid-acetonitrile as the mobile phase, the analytes were gradient elution on a ACQUITY UPLC-BEH C18 column with a total separation time of 13 min, and 14 mixtures showed a good linear relationship in the linear range. The LOQ ranged from 0.005 to 0.2 ng/mL, the inter-day and intra-day precision of each analyte is within 1.2–4.1% and 0.6–3.3%, and the average absolute recovery of all compounds was above 93%. The proposed method has been successfully applied in the clinic and provides a strong technical basis for the quantitative detection of these 14 mixtures for detecting drug abuse, and for studying the stability and compatibility of analgesic solutions. The proposed methods were validated against ICH guidelines.

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Section: Discussionmentioning

confidence: 99%

Simultaneous determination of 14 analgesics in postoperative analgesic solution by HPLC–DAD and LC–MS/MS

Yao,

Fang,

Yang

et al. 2024

BMC Chemistry

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show abstract

“…A Ultra High-Performance Liquid Chromatography (Acquity UPLC H-Class ® , Waters, Guyancourt, France) method, previously developed and validated in 2018 was used (22). The system is interfaced to a photodiode array detector (PDA) operating between 190 and 400 nm and managed by the Empower software (Waters, Guyancourt, France).…”

Section: Analytical Methods Chromatographic Conditionsmentioning

confidence: 99%

Stability Study of Admixtures Combining Ziconotide With Morphine or Sufentanil in Polypropylene Syringes

Sorrieul

Robert

Dupoiron

et al. 2021

Neuromodulation: Technology at the Neural Interface

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“…As described in previously published study, the method was developed and validated according to the International Conference of Harmonization (ICH Q2 R1) (12,13).…”

Section: Methods Parametersmentioning

confidence: 99%

Study of Physicochemical Stability of Ziconotide in Medication Cassette Reservoir

Robert

Sorrieul

Andrieu

et al. 2020

Neuromodulation: Technology at the Neural Interface

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Validated chromatographic method for the simultaneous determination of eight drugs (morphine, ropivacaine, bupivacaine, baclofen, clonidine, sufentanil, fentanyl and ziconotide) for intrathecal analgesia

Cited by 7 publications

References 16 publications

Simultaneous determination of 14 analgesics in postoperative analgesic solution by HPLC–DAD and LC–MS/MS

Simultaneous determination of 14 analgesics in postoperative analgesic solution by HPLC–DAD and LC–MS/MS

Stability Study of Admixtures Combining Ziconotide With Morphine or Sufentanil in Polypropylene Syringes

Study of Physicochemical Stability of Ziconotide in Medication Cassette Reservoir

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