Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction

Lichtman, Judith H.; Leifheit, Erica C; Safdar, Basmah; Bao, Haikun; Krumholz, Harlan M.; Lorenze, Nancy P.; Daneshvar, Mitra; Spertus, John A.; D’Onofrio, Gail

doi:10.1161/circulationaha.117.031650

Cited by 238 publications

(136 citation statements)

References 28 publications

(47 reference statements)

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“…Male gender is an independent cardiovascular risk factor and determines that cardiovascular disease develops at a younger age. On the other hand, the female gender is associated with a higher incidence of atypical symptoms and delays in diagnostic of cardiovascular conditions [ 22 , 23 ]. Overall, life expectancy is higher in women, but age-related comorbidities are also more prevalent [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study

Garay

Tapia

Anguita³

et al. 2020

JCM

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Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 ± 1.3 vs. 62.7 ± 0.8, p < 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 ± 0.01 vs. 0.67 ± 0.01, p < 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity.

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Section: Discussionmentioning

confidence: 99%

Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study

Garay

Tapia

Anguita³

et al. 2020

JCM

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“…Focusing on younger patients, prospective cohort studies, such as GENESIS-PRAXY and VIRGO, have revealed some sex differences in demographic, CV risk factors, symptoms, and treatment. 77 , 78 Additionally, the social determinants of CVD in women have been much discussed, including health literacy, lower education, low-wage jobs, higher rates of poverty, and more familial responsibilities, coupled with societal discriminatory norms and practices. 40 …”

Section: Discussionmentioning

confidence: 99%

“… 81 Women often receive suboptimal CVD-preventive care. 78 A couple of years later, the Women’s Heart Alliance survey selected 200 primary-care providers and 100 cardiologists to determine their self-reported readiness to address CVD risk in women patients. Primary-care providers reported CVD as a principal health concern in women, yet less important than breast- and weight-related health.…”

Section: Discussionmentioning

confidence: 99%

<p>Cardiovascular Diseases in Women: Policies and Practices Around the Globe to Achieve Gender Equity in Cardiac Health</p>

Kouvari¹,

Souliotis²,

Yannakoulia³

et al. 2020

RMHP

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The women's global health agenda has recently been reformulated to address more accurately cardiovascular disease (CVD) prevention, diagnosis, and treatment. The aim of the present work was to review the global and national policies and practices that address sex equality in health with a focus on CVDs in women. Scientific databases and health organizations' websites that presented/discussed policies and initiative targeting to enhance a sex-centered approach regarding general health and/or specifically cardiac health care were reviewed in a systematic way. In total, 61 relevant documents were selected. The selected policies and initiatives included position statements, national action plans, evidence-based guidelines, guidance/recommendations, awareness campaigns, regulations/legislation, and state-of-the art reports by national/international projects and conferences. The target audiences of large stakeholders (eg, American Heart Association, European Society of Cardiology, Centers for Disease Control and Prevention) were female citizens, health professionals, and researchers. Much as policy-makers have recognized the sex/gender gap in the CVD field, there is still much to be done. Thereby, tailor-made strategies should be designed, evaluated, and delivered on a global and most importantly a national basis to achieve gender equity with regard to CVDs.

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“…Hasil penelitian menunjukkan tidak ada hubungan di antara variabel tersebut (Alia et al, 2020). Namun studi lain menemukan hubungan antara rasio trigliserida/HDL dengan kadar Cystatin-C serum pada pasien DM Tipe 2 (Widyatmojo, 2019 (Lichtman, et al, 2018).…”

Section: Pendahuluanunclassified

Gender aspect of triglyceride, HDL, and their ratio in high school teachers in Makassar City, Indonesia

et al. 2020

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Triglycerides, HDL, and their ratio are associated with metabolic disorders and diseases. Gender is known to have a relationship with these factors, but not consistent. This study wanted to see the relationship between gender and triglyceride levels, HDL levels, and the triglyceride / HDL ratio in secondary school teachers in Makassar City. The study was conducted with a cross-sectional approach in 6 junior high schools and 6 senior high schools with a total population of 200 teachers and involved 122 samples of teachers from secondary schools in Makassar City. Sampling using a stratified random sampling technique. The measurement of triglyceride and HDL levels was carried out by the Prodia laboratory. Data analysis was performed using the chi-square test. The results showed that there was a relationship between gender and triglyceride levels (p = 0.004). However, no relationship was found between HDL levels (p = 0.856) and the triglyceride / HDL ratio (p = 0.959) among secondary school teachers in Makassar City. Interventions to improve triglyceride levels must consider gender aspects primarily by paying more attention to male teachers.

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Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction

Cited by 238 publications

References 28 publications

Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study

Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study

<p>Cardiovascular Diseases in Women: Policies and Practices Around the Globe to Achieve Gender Equity in Cardiac Health</p>

Gender aspect of triglyceride, HDL, and their ratio in high school teachers in Makassar City, Indonesia

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