Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study

Garay, Alberto; Tapia, Javier Moreno; Anguita, Manuel; Formiga, Francesç; Almenar, Luís; Crespo‐Leiro, María G.; Manzano, Luís; Muñiz, Javier; Chaves, J. M.; Frutos, Trinidad de; Moliner, Pedro; Corbella, Xavier; Enjuanes-Grau, Cristina; Comín‐Colet, Josep

doi:10.3390/jcm9092825

Cited by 19 publications

(31 citation statements)

References 35 publications

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“…Women report higher symptom frequency, symptom burden, physical limitations and social limitations, as well as lower QoL. These differences do not appear to be mediated by clinical or biological factors (such as age, body mass index, systolic blood pressure) classically associated with HRQoL nor with HF severity ( 17 , 27 , 36 – 38 ).…”

Section: Quality Of Life Of People Living With Heart Failurementioning

confidence: 85%

Palliative Care for People Living With Heart Disease—Does Sex Make a Difference?

Sobański

Krajnik

Goodlin

2021

Front. Cardiovasc. Med.

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The distribution of individual heart disease differs among women and men and, parallel to this, among particular age groups. Women are usually affected by cardiovascular disease at an older age than men, and as the prevalence of comorbidities (like diabetes or chronic pain syndromes) grows with age, women suffer from a higher number of symptoms (such as pain and breathlessness) than men. Women live longer, and after a husband or partner's death, they suffer from a stronger sense of loneliness, are more dependent on institutionalized care and have more unaddressed needs than men. Heart failure (HF) is a common end-stage pathway of many cardiovascular diseases and causes substantial symptom burden and suffering despite optimal cardiologic treatment. Modern, personalized medicine makes every effort, including close cooperation between disciplines, to alleviate them as efficiently as possible. Palliative Care (PC) interventions include symptom management, psychosocial and spiritual support. In complex situations they are provided by a specialized multiprofessional team, but usually the application of PC principles by the healthcare team responsible for the person is sufficient. PC should be involved in usual care to improve the quality of life of patients and their relatives as soon as appropriate needs emerge. Even at less advanced stages of disease, PC is an additional layer of support added to disease modifying management, not only at the end-of-life. The relatively scarce data suggest sex-specific differences in symptom pathophysiology, distribution and the requisite management needed for their successful alleviation. This paper summarizes the sex-related differences in PC needs and in the wide range of interventions (from medical treatment to spiritual support) that can be considered to optimally address them.

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Section: Quality Of Life Of People Living With Heart Failurementioning

confidence: 85%

Palliative Care for People Living With Heart Disease—Does Sex Make a Difference?

Sobański

Krajnik

Goodlin

2021

Front. Cardiovasc. Med.

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“…In heart failure, differences between the sexes in health-related quality of life and health status are controversial. While results of many studies have been heterogeneous, some have reported lower KCCQ scores in female than in male heart failure patients, independently from other clinical factors [ 11 , 13 ]. The reason for lower proportions of women in ICD cohorts is unclear, females with primary prevention ICD has been shown to have a lower mortality and lower risk of appropriate therapy than males [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Health status measured by Kansas City Cardiomyopathy Questionnaire-12 in primary prevention implantable cardioverter defibrillator patients with heart failure

Mattsson

Wallhagen

Magnusson

2021

BMC Cardiovasc Disord

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Background Self-reported health status as measured by the Kansas City Cardiomyopathy Questionnaire (KCCQ) in patients with primary prevention implantable cardioverter defibrillators (ICDs) has mainly been reported from randomized trials. However, these studies are often limited to short follow-up and are subject to selection bias. The aim of this study was to assess KCCQ-12 in patients with primary prevention ICD due to either ischemic or nonischemic heart failure. Methods This cross-sectional observational study included all patients in Region Gävleborg, Sweden, who because of primary prevention due to heart failure, had an ICD or underwent device replacement between 2007 and 2017. After validation using medical records patients were sent and returned the KCCQ-12 by regular mail. Results A total of 118 questionnaires were analyzed (response rate 71.1%). The mean age was 70.9 ± 9.8 years, and a minority was female (n = 20, 16.9%). The mean overall summary score was 71.5 ± 22.4, there was no significant difference between ischemic and nonischemic heart failure (69.5 ± 23.1 vs. 74.4 ± 21.3; p = 0.195). Atrial fibrillation at baseline was associated with lower score for the domains Symptom frequency (70.2 ± 23.2 vs. 82.2 ± 19.2; p = 0.006) and Social limitation (62.1 ± 26.0 vs. 75.6 ± 26.6; p = 0.006) as well as the overall summary score (63.9 ± 21.3 vs. 74.8 ± 22.2; p = 0.004). Conclusion In a real-world setting, primary prevention ICD patients with heart failure report an acceptable disease-specific health status at long-term follow-up. Ischemic and nonischemic etiology showed similar health status whereas atrial fibrillation was associated with worse outcome.

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“…Broadening the picture, gender-specific differences have been emphasized for conceptualizations of patients' presenting difficulties, treatment plans, and mental and medical healthcare pathways [34][35][36][37]. Overall, available evidence suggests that women tend to report higher HRQoL impairments in the context of psychological [38][39][40] or medical difficulties [41,42]. For chronic tinnitus, similar patterns emerged with women describing higher levels of emotional tension, psychological distress, and functional impairment [43][44][45][46], although these findings remain inconclusive [47,48].…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life, Depressive Symptoms, Anxiety, and Somatization Symptoms in Male and Female Patients with Chronic Tinnitus

Boecking¹,

Biehl²,

Brüeggemann³

et al. 2021

JCM

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Objective: To investigate the joint impact of tinnitus-related distress (TRD), anxiety, depressive symptoms, and other somatization symptoms on health-related quality of life (HRQoL) in female vs. male patients with chronic tinnitus. Method: Three-hundred-and-fifty-two patients with chronic tinnitus completed audiological testing and a psychological assessment battery that comprised—among other measures—German versions of the Tinnitus Questionnaire, Hospital Anxiety and Depression Scale, Somatic Symptom Scale-8, and Health-Related Quality of Life scale. Descriptive analyses examined associations as well as within- and between-gender differences of the measured variables. Gender-specific serial indirect effects analyses aimed to explain the impact of TRD on HRQoL through psychological processes, notably anxiety, depressive symptoms, and somatization symptoms. Results: Both female and male patients yielded lower mental than physical HRQoL and negative associations between the measured psychological variables and HRQoL. Compared to male patients, female patients reported higher levels of tinnitus-related- and wider psychological distress, other somatization symptoms (e.g., headaches), and impairments in mental and physical HRQoL. For each gender, depressive symptoms, anxiety, and somatization symptoms fully mediated the effect of TRD on mental and physical HRQoL. A double-dissociation revealed an interaction of somatization symptoms and depression on the TRD-HRQoL association in women, and of somatization symptoms and anxiety in men. Conclusions: In patients with chronic tinnitus, psychological constructs account for reported impairments in both mental and physical HRQoL. To improve patients’ HRQoL, treatment conceptualizations should consider gender-specific psychological expressions of low mood or anxiety.

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Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study

Cited by 19 publications

References 35 publications

Palliative Care for People Living With Heart Disease—Does Sex Make a Difference?

Palliative Care for People Living With Heart Disease—Does Sex Make a Difference?

Health status measured by Kansas City Cardiomyopathy Questionnaire-12 in primary prevention implantable cardioverter defibrillator patients with heart failure

Health-Related Quality of Life, Depressive Symptoms, Anxiety, and Somatization Symptoms in Male and Female Patients with Chronic Tinnitus

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