Dextran based herbal nanobiocomposite membranes for scar free wound healing

Singh, Surabhi; Gupta, Amlan; Sharma, Deepika; Gupta, Bhuvanesh

doi:10.1016/j.ijbiomac.2018.02.097

Cited by 48 publications

(21 citation statements)

References 34 publications

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“…Moreover, chemically modified dextran has been reported to exert antibacterial property, specifically against S. aureus 19 . A dextran-based nano bio-composite membrane containing essential oils from herbs has been developed as a topical formulation 20 . A recent study suggested that sanguinarine-containing hydrogels prepared using dextran–hyaluronic acid enhanced healing of burn wounds 21 .…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent

Madkhali

Moni

Sultan

et al. 2021

Sci Rep

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The purpose of this study was to develop a novel nano antibacterial formulation of dextran sulfate sodium polymer. The dextran sulfate sodium (DSS) nanoparticles were formulated with gelation technique. The nanoparticles exhibited significant physicochemical and effective antibacterial properties, with zeta potential of − 35.2 mV, particle size of 69.3 z d nm, polydispersity index of 0.6, and percentage polydispersity of 77.8. The DSS nanoparticles were stable up to 102 °C. Differential scanning calorimetry revealed an endothermic peak at 165.77 °C in 12.46 min, while XRD analysis at 2θ depicted various peaks at 21.56°, 33.37°, 38.73°, 47.17°, 52.96°, and 58.42°, indicating discrete nanoparticle formation. Antibacterial studies showed that the DSS nanoparticles were effective against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentrations of DSS nanoparticles for Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), Streptococcus pyogenes (S. pyogenes), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Klebsiella pneumoniae (K. pneumoniae) and Proteus vulgaris (P. vulgaris) were 150, 200, 250, 150, 200, 250, 250 µg/mL, respectively. The antibacterial effects of DSS nanoparticles were in the order E. coli (26 ± 1.2 mm) at 150 µg/mL > S. pyogenes (24.6 ± 0.8 mm) at 250 µg/mL > B. subtilis (23.5 ± 2 mm) at 150 µg/mL > K. pneumoniae (22 ± 2 mm) at 250 µg/mL > P. aeruginosa (21.8 ± 1 mm) at 200 µg/mL > S. aureus (20.8 ± 1 mm) at 200 µg/mL > P. vulgaris (20.5 ± 0.9 mm) at 250 µg/mL. These results demonstrate the antibacterial potency of DSS injectable nanoparticles.

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Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent

Madkhali

Moni

Sultan

et al. 2021

Sci Rep

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“…The unique features of these polymers are biodegradability and biocompatibility and hence offer huge potential in the biomedical sector, such as wound dressings, drug delivery, water treatment, and coating materials. [1][2][3][4][5][6] These polymers have a wide range of functionality, such as hydroxyl, carboxyl, and amino groups which may be used to conjugate with drugs, proteins, and enzymes.…”

Section: Introductionmentioning

confidence: 99%

Smart Designing of Tragacanth Gum by Graft Functionalization for Advanced Materials

Verma¹,

Pathania

Anjum³

et al. 2020

Macro Materials & Eng

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Tragacanth gum is a novel polysaccharide which offers interesting features in terms of high hydrophilicity, good biocompatibility, and biodegradability. The engineering of hydrogels requires careful designing of their macromolecular structures so that desirable features may be incorporated into the material. Graft polymerization has come up as an interesting approach to develop molecules for drug delivery, wound care systems, and infection‐resistant materials. The most important aspect of graft functionalization is the proper control over physico‐chemical properties of the grafted matrix. The extent of functionalization may be governed by the grafting parameters and may lead to the chemical designing of the molecule in a controlled manner. This opens up enormous possibilities of developing materials for a wide range of applications as advanced materials.

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“…Essential oils, also referred to as volatile natural mixtures, are secondary plant metabolites extracted from the flowers, seeds, leaves and fruit of plants 3,6 . These natural oils are, primarily made up of unsaturated hydrocarbons termed terpenes, polyphenols and fatty acids and, together, these components are responsible for the medicinal, culinary and fragrant uses of some plants 14 . Many essential oils have been reported to possess antimicrobial properties in in-vitro assays 7 , in pre-clinical rodent models of wound repair 14,15 , and in human clinical trials 11,12 primarily attributed to polyphenols and terpenes, (primarily monoterpenes), eugenol, cinnamaldehyde, carvacrol, and thymol 11 .…”

Section: The Use Of Essential Oils In Wound Healing and Infectionmentioning

confidence: 99%

“…These natural oils are, primarily made up of unsaturated hydrocarbons termed terpenes, polyphenols and fatty acids and, together, these components are responsible for the medicinal, culinary and fragrant uses of some plants 14 . Many essential oils have been reported to possess antimicrobial properties in in-vitro assays 7 , in pre-clinical rodent models of wound repair 14,15 , and in human clinical trials 11,12 primarily attributed to polyphenols and terpenes, (primarily monoterpenes), eugenol, cinnamaldehyde, carvacrol, and thymol 11 . However, the composition of essential oils from the same plant species varies based on a variety of factors, including differences in growing conditions, in storage and processing conditions, and in the method of oil extraction 7,16 .…”

Section: The Use Of Essential Oils In Wound Healing and Infectionmentioning

confidence: 99%

Antimicrobial and healing-promoting properties of animal and plant oils for the treatment of infected wounds

Kennewell¹,

Mashtoub²,

Howarth³

et al. 2019

WPR

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Dextran based herbal nanobiocomposite membranes for scar free wound healing

Cited by 48 publications

References 34 publications

Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent

Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent

Smart Designing of Tragacanth Gum by Graft Functionalization for Advanced Materials

Antimicrobial and healing-promoting properties of animal and plant oils for the treatment of infected wounds

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