Association of salivary lactate dehydrogenase level with systemic inflammation in a Japanese population

Miyoshi, Noriko; Tanigawa, Takeshi; Nishioka, Shinji; Maruyama, Koutatsu; Eguchi, Eri; Tanaka, Kumiko; Saito, Isao; Yamazaki, Kazuhisa; Miyake, Yoshihiro

doi:10.1111/jre.12537

Cited by 21 publications

(15 citation statements)

References 38 publications

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“…The use of LDH in predicting PSD may also be related to inflammatory responses, because LDH has been reported as a promising biomarker for inflammatory burden, and its inhibitors can be used as antiinflammatory agents. 29,30 Consistent with previous studies, the BDNF level in the PSD group was lower than that in the non-PSD group in our study. 31,32 Moreover, the AIS patients in the lower tertile of LDH had higher BDNF and lower CRP than the other two groups.…”

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confidence: 92%

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Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Li¹,

Miao²,

Pan³

et al. 2021

CIA

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Purpose: Post-stroke depression (PSD) is one of the most common and severe psychological sequelae after stroke, negatively affecting the patient's functional outcome and quality of life. Rapidly measurable biomarkers to predict PSD are pivotal for the optimized care and allocation of healthcare resources. Lactic dehydrogenase (LDH) levels are increased in patients with central nervous system (CNS) disorders such as cerebral infarction and hypoxic-ischemic encephalopathy, which may be related to the occurrence of PSD in acute ischemic stroke (AIS) patients. This study aimed to investigate whether LDH levels on admission are associated with PSD at discharge. Patients and Methods: A multicenter prospective cohort study was conducted, including all consecutive AIS patients within 7 days after symptom onset from May 2018 to October 2019. According to the distribution of LDH and the number of patients, patients were divided into equal tertiles. PSD was evaluated by DSM-V criteria and the 17-item Hamilton Rating Scale for Depression (HRSD-17) at discharge. Results: A total of 518 AIS patients were included. The optimal cut-off points of LDH were: lowest tertile (T1) 102-159/L, middle tertile (T2) 160-189 U/L, and upper tertile (T3) 190-520 U/L. A total of 249 patients (48.07%) were diagnosed with PSD at discharge. After adjusting for potential confounding factors, the odds ratio of T3 PSD was 1.698 (95% CI, 1.070-2.694, P=0.025), compared with T1. Conclusion: In summary, LDH serum levels on admission are associated with PSD at discharge. Clinicians should pay more attention to the baseline LDH level in screening for PSD at discharge.

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confidence: 92%

Section: Discussionmentioning

confidence: 99%

Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Li¹,

Miao²,

Pan³

et al. 2021

CIA

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“…PD was measured at six sites per tooth using an automated probe with a constant force (20 g) on all teeth present in the mouth, excluding the third molars. PD ≥ 4 mm was considered an indicator of chronic periodontitis 25) .…”

Section: Covariatesmentioning

confidence: 99%

Salivary Alpha-Amylase Activity in Relation to Cardiometabolic Status in Japanese Adults without History of Cardiovascular Disease

Ikeda

Steptoe

Brunner

et al. 2021

JAT

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Stress is known to be a potential contributor to the development of diabetes and hypertension. However, the biological mechanisms underlying the association between cardiometabolic risk markers and the biological stress response have not yet been determined. Therefore, we examined salivary alpha-amylase and heart rate variability in relation to cardiometabolic status in a sample of healthy Japanese men and women.Methods: Participants (473 men and 1,029 women aged 30-84) underwent a 75 g oral glucose tolerance test after a 10-hr fast. The homeostasis model assessment index for insulin resistance was based on fasting and 2-hr postload glucose and insulin concentrations. Sitting blood pressure was measured twice after rest. A saliva sample was collected in the morning and salivary alpha-amylase was assayed. A 5-min heart rate variability recording was evaluated using time-domain indices of standard deviations of normal-to-normal intervals and root mean square of successive differences. Multivariate linear regression models were used to estimate associations between salivary alpha-amylase and each outcome measure.Results: Salivary alpha-amylase was associated with fasting glucose ( 0.008; 95% CI 0.002, 0.014), 2-hr postload glucose ( 0.023; 95% CI 0.004, 0.041), homeostasis model assessment index for insulin resistance ( 0.032; 95%CI 0.000, 0.064), systolic ( 1.603; 95% CI 0.479, 2.726) and diastolic ( 0.906; 95% CI 0.212, 1.600) blood pressures among women. These associations remained significant after further adjustment for heart rate variability measures. Conclusions:The elevation of salivary alpha-amylase may reflect a dysfunction of the sympathetic nervous system associated with cardiometabolic abnormalities in women.of type 2 diabetes and the population attributable fraction for cardiovascular disease have increased markedly 2) . Stress is a potential contributor to chronic hyperglycemia in diabetes 3,4) . Previous epidemiological studies have confirmed the association of stress with a higher risk of developing type 2 diabetes melli-Copyright©2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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“…Diagnostic advancements in periodontitis continue to benefit from integration of salivary biomarker information with findings from clinical and radiographic assessments (Barnes et al, 2014; de Lima et al, 2016; Miyoshi et al, 2018; Nagarajan et al, 2015). Biomolecules found in saliva have the advantage of early noninvasive detection of host defence and inflammatory events that likely precede clinical and radiographic evidence of periodontal tissue damage (Chan et al, 2012; Glimvall et al, 2012; Nagarajan et al, 2019; Salminen et al, 2014; Taylor, 2014).…”

Section: Introductionmentioning

confidence: 99%

Salivary biomarkers for discriminating periodontitis in the presence of diabetes

Miller

Ding

Dawson

et al. 2020

J Clinic Periodontology

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AimSalivary biomarkers can help in assessment of periodontitis; however, concentrations may be altered in the presence of diabetes. Hence, the ability of salivary biomarkers to discriminate periodontally healthy type II diabetics (T2DM) from T2DM who have periodontitis was examined.MethodsNinety‐two participants (29 with T2DM with chronic periodontitis, DWP; 32 T2DM without chronic periodontitis, DWoP; and 31 Not Periodontitis, NP) provided saliva and clinical parameters of periodontal health were recorded. Salivary concentrations of interleukin (IL)‐1β, IL‐6, matrix metalloproteinase‐8 (MMP‐8), macrophage inflammatory protein‐1α (MIP‐1α), adiponectin and resistin were measured by immunoassay.ResultsSalivary analyte concentrations for IL‐1β, MMP‐8 and resistin correlated with clinical parameters of periodontitis, with MMP‐8 demonstrating the strongest positive correlation with PD ≥5 mm (p < 0.0001). Periodontal health was reflected in salivary analyte concentrations by group, with concentrations of IL‐1β and MMP‐8 showing significant associations with periodontitis (p ≤ 0.04) that increased in concentration from health to DWoP to DWP. Odds ratio (OR) analyses showed that MMP‐8 discriminated periodontitis from NP (OR of 8.12; 95% CI: 1.01–65.33; p = 0.03) and in the presence of T2DM (DWP vs DWoP, OR = 5.09; 95% CI: 1.24–20.92; p = 0.03).ConclusionSalivary MMP‐8 and IL‐1β discriminate periodontitis in T2DM.

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Association of salivary lactate dehydrogenase level with systemic inflammation in a Japanese population

Cited by 21 publications

References 38 publications

Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Higher Serum Lactic Dehydrogenase is Associated with Post-Stroke Depression at Discharge

Salivary Alpha-Amylase Activity in Relation to Cardiometabolic Status in Japanese Adults without History of Cardiovascular Disease

Salivary biomarkers for discriminating periodontitis in the presence of diabetes

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