Synthesis of Mesoporous Yolk-Shell Magnetic Prussian Blue Particles for Multi-Functional Nanomedicine

Abstract

Mesoporous magnetic Prussian Blue (PB) particles are good condidates for theragnostic nanomedicine. However, there are lack of efficient methods for fabrication of such materials. Here, we reported the synthesis of the mesoporous yolk-shell Fe3O4@PB particles by one-pot coordination replication and etching. Time-dependent transmission electron microscopy illustrated that the PB crystals nucleated and grew on the surface of Fe3O4 spheres by coordination replication with the help of protons. The extra protons in the reaction medium further disassociated the Fe3O4 and PB, leading to mesoporous particles. The mesoporous yolk-shell Fe3O4@PB particles showed enhanced efficacy for loading cisplatin. The release of the drug molecules could be facilitated by increasing temperature. Both photo irradiation and alternating magnetic fields could trigger the release of heat from the composite. The obtained materials could delivery cisplatin to kill cancer cell intracellularly.

<p>Hollow Prussian Blue Nanospheres for Photothermal/Chemo-Synergistic Therapy</p>

“…16 A large number of studies have shown that Prussian blue nanoparticles have some important characteristics in the biological environment, such as stability in human serum and efficient cell uptake. [17][18][19][20][21][22] More importantly, PB nanoparticles are a typical US FDA-approved drug in the clinic for treatment of radioactive exposure, demonstrating absolutely approved biosafety in the human body based on sufficient clinical trials. Hollow Prussian nanoparticles have attracted much attention due to their potential to encapsulate large quantities of guest molecules within their empty core domain.…”