Detection of ISE cp1- associated bla CTX-M-15 –mediated resistance to colistin in KPC-producing Klebsiella pneumoniae isolates

Carbapenemase-producing organisms are pandemic and a significant threat to public health. We investigated the clonal relatedness of colistin-resistant Klebsiella pneumoniae strains producing KPC-type carbapenemase (KPC-KP) causing subsequent infections or colonization. Moreover, we aimed to gain insight into the ability of biofilm production in K. pneumoniae strains producing carbapenemase. Twenty-two consecutive KPC-KP and one KPC-negative strain was identified from an adult intensive care unit in Brazil. Seventy-five percent of isolates that harbored the bla gene exhibited genetic relatedness by pulsed-field gel electrophoresis, and none presented the plasmid-mediated mcr-1 and bla genes. This study showed that the majority of repeated KPC infections in adults were caused by a clone that caused the previous infections/colonizations even after a long period of time and illustrates the capacity of multiple clones producing biofilms to coexist in the same patient at the same time, becoming a reservoir of KPC-KP in the hospital environment.

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Detection of ISE cp1- associated bla CTX-M-15 –mediated resistance to colistin in KPC-producing Klebsiella pneumoniae isolates

Cited by 4 publications

References 6 publications

Polymyxin resistance in Enterobacterales: overview and epidemiology in the Americas

Polymyxin resistance in Enterobacterales: overview and epidemiology in the Americas

A phylogenomic approach for the analysis of colistin resistance-associated genes in Klebsiella pneumoniae, its mutational diversity and implications for phenotypic resistance

Association of Colistin-Resistant KPC Clonal Strains with Subsequent Infections and Colonization and Biofilm Production

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