Herpes simplex virus type 2 IgG antibodies in sera of umbilical cord as a proxy for placental infection in asymptomatic pregnant women

Finger‐Jardim, Fabiana; Avila, Emiliana Claro; Hora, Vanusa Pousada da; Santos, Paula Costa; Gonçalves, Carla Vitola; Mor, Gil; Martínez, Ana Maria Barral de; Soares, Marcelo A.

doi:10.1111/aji.12824

Cited by 5 publications

(3 citation statements)

References 65 publications

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“…En un estudio realizado en un hospital de Paraguay, se observó que el VHS afectó al 32,5% de las mujeres embarazadas -con mayor prevalencia entre los 25 y 39 años-, las cuales eran solteras y provenían de zona urbana 12 . Aunque es poco frecuente, el VHS-1 y VHS-2 pueden encontrarse tanto en la placenta como en la sangre del cordón umbilical e infectar al feto, lo cual puede causarle daños graves al recién nacido 13 , 14 . Por ello, es importante tener todos los controles y medidas de prevención durante el embarazo.…”

Section: Materiales Y Métodosunclassified

Factores predisponentes para herpes simple: Actualización de la literatura

Begazo-Morán

Morante-Félix

Espinoza-Montes

2022

Rev Cient Odontol (Lima)

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El virus del herpes simple, despues de la primera infeccion, puede permanecer latente en los ganglios　y reactivarse en cualquier momento debido a ciertos factores o estimulos, lo que ocasiona efectos　en el paciente. El objetivo de esta revision de literatura es actualizar la informacion cientifica sobre　los factores que predisponen la reactivacion del virus del herpes simple. Se realizo una revisión　bibliografica exhaustiva en las bases de datos LILACS, SciELO, PubMed y Scopus, mediante　las palabras clave “herpes simple”, “reactivacion”, “latencia” y “riesgos”. Entre los factores descritos　estan la reactivacion por inmunosupresion debido a la ingesta de inmunosupresores o la terapia　oncologica. Otro factor es el estres psicologico, en el cual las hormonas liberadas actuan sobre senales mediadoras de la reactivacion, asi como la exposicion solar, que reactiva al virus en las neuronas infectadas, y la infeccion en mujeres gestantes, que puede desencadenar complicaciones en el feto y en el momento del parto.

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Section: Materiales Y Métodosunclassified

Factores predisponentes para herpes simple: Actualización de la literatura

Begazo-Morán

Morante-Félix

Espinoza-Montes

2022

Rev Cient Odontol (Lima)

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“…In the USA, the HSV-1 seroprevalence declined by nearly 7% ( p < 0.01) while the highest decline >29% ( p < 0.01) was found among 14–19-year-olds from 1999–2004 to 2005–2010 [ 10 ]. HSV seroepidemiology is mostly affected by geographic location, age, socioeconomic status, personal hygiene, and behavioral factors such as age at sexual debut and number of sexual partners and is highly dependent on which kind of cohort is being studied [ 6 , 8 , 9 , 10 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Herpes Simplex Virus Seroprevalence among Pregnant Finnish Women and Their Spouses—A Six-Year Follow-Up Cohort Study

et al. 2022

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The aim was to evaluate the herpes simplex virus (HSV) seroprevalence and seroconversion among 285 pregnant women and their 120 male spouses in Finland during a six-year follow-up (FU) between 1998–2008. We also studied the effect of sexual habits, pregnancy, and other demographic factors on the acquisition of HSV infection. Combined HSV-1 and HSV-2-IgG antibodies were assessed in the first baseline serum samples with an indirect enzyme immunoassay method. The individuals with seronegative or borderline HSV serology at baseline were additionally tested using their latest FU serum sample available. The overall HSV seroprevalence during the FU was 58.9% (168/285) among the women and 53.3% (64/120) among their spouses. The seroconversion rate was 11.4% (15/132) and 12.5% (8/64) among women and their spouses, respectively. Both spouses were HSV seropositive in 39.2% (47/120). To determine the HSV-2 seroprevalence, we also tested all HSV-seropositive participants using HSV-2-specific antigen. HSV-2 seropositivity was detected in 10.9% (44/405) of the participants. The age (p = 0.006) and history of genital warts (p = 0.006) of the women were associated with combined HSV-1 and/or HSV-2 seropositivity, while a younger age was related to HSV seroconversion (p = 0.023). Among the male spouses, HSV seropositivity was associated with the practice of oral sex (p = 0.033). To conclude, women of childbearing age acquire primary HSV infections and the presence of HSV in oral epithelium is common among HSV-seropositive individuals.

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“…Human immunoglobulin G (IgG) has been identified as the human body antibody with the highest abundance [1] , [2] , [3] . Besides, IgG is the only human immunoglobulin that can pass through the placenta, which exerts a vital part in the anti-infective immunity in newborns [4] , [5] , [6] . IgG is highly expressed in serum and accounts for 75–80% of all immunoglobulins in serum.…”

Section: Introductionmentioning

confidence: 99%

An advanced molecularly imprinted electrochemical sensor for the highly sensitive and selective detection and determination of Human IgG

Liang

Hou

Tang

et al. 2021

Bioelectrochemistry

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Herpes simplex virus type 2 IgG antibodies in sera of umbilical cord as a proxy for placental infection in asymptomatic pregnant women

Abstract: We describe for the first time that newborns from mothers with HSV-2 placental infection have higher IgG titers in sera of umbilical cord, suggesting IgGs antibodies can be indicative of placental viral infection in asymptomatic women.

Cited by 5 publications

References 65 publications

Factores predisponentes para herpes simple: Actualización de la literatura

Factores predisponentes para herpes simple: Actualización de la literatura

Herpes Simplex Virus Seroprevalence among Pregnant Finnish Women and Their Spouses—A Six-Year Follow-Up Cohort Study

An advanced molecularly imprinted electrochemical sensor for the highly sensitive and selective detection and determination of Human IgG

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