Survival, complications and functional outcomes of cemented megaprostheses for high-grade osteosarcoma around the knee

Zhang, Chunlin; Hu, Jianping; Zhu, Kun Yan; Cai, Tao; Ma, Xiaolong

doi:10.1007/s00264-018-3770-9

Cited by 57 publications

(52 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our own series of 520 non metastatic osteosarcomas treated with limb salvage surgery (excluding ECRT) had a similar local recurrence rate of 10% . In the series by Mavrogenis et al 8% (12 of 151) of osteosarcomas reconstructed with a megaprosthesis had local recurrence while Zhang et al documented 9% (10 of 108) local recurrence in their study of megaprostheses for high‐grade osteosarcoma around the knee. Similarly, the series by Ortiz‐Cruz et al demonstrated a 9% (four of 47) rate of local recurrence in high grade sarcomas reconstructed with an intercalary allograft.…”

Section: Discussionmentioning

confidence: 51%

Reconstructing diaphyseal tumors using radiated (50 Gy) autogenous tumor bone graft

Puri

Byregowda

Gulia

et al. 2018

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 51%

Reconstructing diaphyseal tumors using radiated (50 Gy) autogenous tumor bone graft

Puri

Byregowda

Gulia

et al. 2018

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…Although the five-year survival rate has been improved to 60-75% thanks to the rapid development of treatment strategies, the prognosis remained poor for the complicated carcinogenesis of OS is still unclear [2]. erefore, it is of great urgency to seek for new biomarkers that targeted preventive and/or therapeutic interventions for OS patients to improve the clinical outcome [3,4].…”

Section: Introductionmentioning

confidence: 99%

miR-509-5p Inhibits the Proliferation and Invasion of Osteosarcoma by Targeting TRIB2

Guo

Peng

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Osteosarcoma (OS) is one of the most common malignant bone tumors in adolescents with a poor prognosis. Though miR-509-5p has been reported as a tumor suppressor in several human cancers, the role of miR-509-5p in OS remains unclear. In this study, our result of real-time PCR (RT-PCR) showed that the expression of miR-509-5p was significantly decreased in OS tissues and cell lines. Overexpression of miR-509-5p significantly suppressed cell proliferation and invasion in OS cell lines. Moreover, we identified tribbles homolog 2 (TRIB2) as the direct target of miR-509-5p. Knockdown of TRIB2 could inhibit the malignant capacity of OS cells. At last, we reported that TRIB2 could inhibit the bioactivity of the tumor suppressor gene p21 via blocking its transcriptional activity. Collectively, our study revealed that miR-509-5p functions as a tumor suppressor by targeting TRIB2 in OS and thus could affect the activity of p21, suggesting that miR-509-5p is a novel preventive intervention for OS patients.

show abstract

“…The 3D-printed prosthesis for the patients in our study were designed by ourselves. According to previous research, aseptic loosening would be the most common complication for the patients with prosthesis replacement in distal femur [16][17]. So, the proximal femoral medullary stalk of the prosthesis and the lateral auxiliary plate would be biological xation type by 3D-printed technology to promote the bone union and prevent the prosthesis from loosening and rotation.…”

Section: Discussionmentioning

confidence: 99%

Surgical Technique and Outcome of Joint Sparing Limb Salvage Surgery by Three-Dimensional-Printed Prothesis for Children with Osteosarcoma in Distal Femur

Cai

Zhang

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Purpose The purpose of this study was to introduce the surgical technique and functional outcome of joint-sparing limb salvage surgery with metaphyseal osteotomy by dependent design of three-dimensional printed prothesis for children with osteosarcoma in distal femur.Methods Between 2012 to 2019, we performed twelve joint sparing limb salvage surgeries (JSLSS) with metaphyseal osteotomy for the children of osteosarcoma in the distal femur with our dependent design of 3D-printed guided plate and prothesis. The clinical assessment including resection margin, limb-length discrepancy, orthopaedic complications and functional outcome would be analyzed.Results The mean operation time for JSLSS was 107.6 minutes and the average blood loss was 194.5ml with the dependent design of 3D-printed prosthesis. With the assistance of guide plate, the mean margin of the osteosarcoma from the epiphyseal plate was 1.6 cm and the mean limb-length discrepancy was 2.2 cm with maximum follow-up period of seven years (mean 45.3 months, range 12-84 months). All the patients could bend their knee through >90° flexion, achieved similar results for ROMs in 6DOF during gait compared with normal data of Chinese knees, and the mean MSTS score was 94.7 for the patients with JSLSS. One patient had a superficial infection and there was one patient of local recurrence happened during the follow-up with the necrosis rate less than 90% by preoperative chemotherapy. None aseptic loosening happened in distal femur for the patients in this group with dependent design of 3D-printed prosthesis.Conclusion Joint-sparing limb salvage surgery by metaphyseal osteotomy with the dependent design of 3D-printed prosthesis and guide plate would be a good choice for the children with osteosarcoma in distal femur.

show abstract

Survival, complications and functional outcomes of cemented megaprostheses for high-grade osteosarcoma around the knee

Cited by 57 publications

References 50 publications

Reconstructing diaphyseal tumors using radiated (50 Gy) autogenous tumor bone graft

Reconstructing diaphyseal tumors using radiated (50 Gy) autogenous tumor bone graft

miR-509-5p Inhibits the Proliferation and Invasion of Osteosarcoma by Targeting TRIB2

Surgical Technique and Outcome of Joint Sparing Limb Salvage Surgery by Three-Dimensional-Printed Prothesis for Children with Osteosarcoma in Distal Femur

Contact Info

Product

Resources

About