Canine case of swallowing syncope that improved after pacemaker implantation

Fukushima, Ryuji; Araie, Toshiki; Itou, Naoaki; Kawaguchi, Takae; Yamada, Shusaku; Yoshimura, Aritada; Goya, Seijirow; Shimada, Kazumi; Uchide, Tsuyoshi; Kishimoto, Miori; Motomura, Noboru

doi:10.1292/jvms.17-0451

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…Based on the trigger, reflex syncope can be classified as VVS (mediated by emotion or by orthostatic stress), situational syncope (traditionally associated with specific circumstances, such as cough, swallowing, post-exercise, vomiting, micturition, and defecation), carotid sinus syncope (mechanical manipulation of the carotid sinuses), and 'atypical form' with uncertain or even apparently absent triggers [92]. Swallowing and cough syncope have been reported in the dog [93,94]. In human medicine, it has been proposed that frequent vasovagal-mediated cardiac asystole may be a potential cause of sudden cardiac death [95].…”

Section: Disturbances Of the Autonomic Nervous Systemmentioning

confidence: 99%

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Indications for permanent pacing in dogs and cats

Santilli

Giacomazzi²,

Vázquez³

et al. 2019

Journal of Veterinary Cardiology

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Pacemaker implantation is considered as a standard procedure for treatment of symptomatic bradycardia in both dogs and cats. Advanced second-degree and third-degree atrioventricular blocks, sick sinus syndrome, persistent atrial standstill, and vasovagal syncope are the most common rhythm disturbances that require pacing to either alleviate clinical signs or prolong survival. Most pacemakers are implanted transvenously, using endocardial leads, but rarely epicardial leads may be necessary. To decide whether a patient is a candidate for pacing, as well as which pacing modality should be used, the clinician must have a clear understanding of the etiology, the pathophysiology, and the natural history of the most common bradyarrhythmias, as well as what result can be achieved by pacing patients with different rhythm disturbances. The goal of this review was, therefore, to describe the indications for pacing by evaluating the available evidence in both human and veterinary medicine. We described the etiology of bradyarrhythmias, clinical signs and electrocardiographic abnormalities, and the choice of pacing modality, taking into account how different choices may have different physiological consequences to selected patients. It is expected that this review will assist veterinarians in recognizing arrhythmias that may require permanent pacing and the risk-benefit of each pacing modality and its impact on outcome. ª

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Section: Disturbances Of the Autonomic Nervous Systemmentioning

confidence: 99%

“…Few data are available regarding the diagnosis of VVS syncope in dogs [12,93,94,106]. The diagnosis can be performed with the ambulatory electrocardiography, which can document the presence of prolonged vagal-induced cardio- Fig.…”

Section: Disturbances Of the Autonomic Nervous Systemmentioning

confidence: 99%

Indications for permanent pacing in dogs and cats

Santilli

Giacomazzi²,

Vázquez³

et al. 2019

Journal of Veterinary Cardiology

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“…Its pathogenesis generally involves a disorder of the autonomic nervous system: a rapid increase in vagal activity, decrease in sympathetic activity, and decrease in cardiac preload. Situational syncope includes fainting attacks caused by micturition, swallowing, coughing, breath-holding (Valsalva maneuver), and vomiting, as reported in humans and dogs ( Brignole et al, 2018 ; Fukushima et al, 2018 ; Santilli et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Involvement of neurokinin-1 receptors in the autonomic nervous system in colorectal distension-induced cardiovascular suppression in rats

Kurogochi

Uechi²,

Orito³

2022

Front. Pharmacol.

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Situational syncope, which includes rectally mediated reflexes, is defined as syncope induced by a specific situation. Its pathogenesis generally involves disorders of the autonomic nervous system. However, the mechanisms and preventive strategies are not yet well understood. Therefore, we hypothesized that a tachykinin neurokinin-1 receptor might be involved in the autonomic nervous system, and that a neurokinin-1 receptor antagonist could mitigate reflex syncope. This study used a rat model in which the reflex was induced by afferent vagal stimulation with colorectal distension (CRD). In the study, the rats were divided into three groups: non-CRD, CRD, and CRD with a neurokinin-1 receptor antagonist. First, we examined the effect of fosaprepitant, a neurokinin-1 receptor antagonist, on the circulatory response in this model. We then determined the brain regions that showed increased numbers of c-Fos immunoreactive cells in the respective groups. Our results suggest that the colorectal distension procedure reduced blood pressure and that fosaprepitant lowered this response. In addition, the number of c-Fos immunoreactive cells was increased in the caudal ventrolateral medullary region with colorectal distension, and this number was decreased by the administration of fosaprepitant. In conclusion, fosaprepitant might be involved in the vagal reflex pathway and potentially suppress the circulatory response to colorectal distension.

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Neurally mediated syncope starting in old age does not appear to be unique to humans: new perspective

Alboni¹,

Perego²

2021

Clin Auton Res

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Canine case of swallowing syncope that improved after pacemaker implantation

Cited by 4 publications

References 21 publications

Indications for permanent pacing in dogs and cats

Indications for permanent pacing in dogs and cats

Involvement of neurokinin-1 receptors in the autonomic nervous system in colorectal distension-induced cardiovascular suppression in rats

Neurally mediated syncope starting in old age does not appear to be unique to humans: new perspective

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