Comparison the clinical outcomes with altered versus conventional fractionated radiotherapy plus concurrent chemotherapy for advanced nasopharyngeal carcinoma

Lin, Po Ju; Twu, Chih Wen; Liu, Yichun; Lin, Tian; Wang, Wen Yi; Jia, Lin

doi:10.1002/hed.25084

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Self-care plus forecasting nursing intervention was carried out in this study so that the patients could have a good knowledge of the possible adverse reactions and targeted countermeasures before radiotherapy. Moreover, the patients were informed about the fact that effective nursing could cut down on the incidence of adverse reactions, thus helping them rebuild confidence and improve compliance [ 24 ]. After the intervention of mental health nursing, most patients could take a positive attitude towards treatment and show a relatively good psychological status, enabling them to fulfill radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Chen

Yao

Ding

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the effects of self-care plus forecasting nursing on the treatment outcomes and emotions in nasopharyngeal carcinoma patients undergoing radiotherapy. Methods. Eighty nasopharyngeal carcinoma patients after radiotherapy admitted to our hospital from February 2020 to August 2021 were selected. The patients were allocated into an observation group (n = 40) and an experimental group (n = 40) according to different nursing protocols. The observation group received traditional nursing intervention, whereas the experimental group received self-care plus forecasting nursing intervention. The levels of the indexes (quality of life, score on the Zung Self-Rating Anxiety Scale (SAS), score on the Zung Self-Rating Depression Scale (SDS), and adverse reaction) were compared between the two groups. Results. The score of the experimental group for the quality of life was significantly higher than that of the observation group ( P < 0.05 ); the SAS and SDS scores of the experimental group after nursing intervention were significantly lower than those of the observation group ( P < 0.05 ); the incidence of adverse reactions in the experimental group during radiotherapy was significantly lower than that of the observation group ( P < 0.05 ). Conclusion. The self-care plus forecasting nursing intervention is effective in postradiotherapy patients with nasopharyngeal carcinoma. The technique is proved effective to improve the quality of life, reduce anxiety and depression, and decrease the incidence of adverse reactions in patients during treatment. These features make the technique worthy of a wider clinical application.

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Section: Discussionmentioning

confidence: 99%

Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Chen

Yao

Ding

2022

Evidence-Based Complementary and Alternative Medicine

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“…Poorly differentiated squamous cell carcinoma is the most common type of NPC, whereas the incidence of other types of NPC, including highly differentiated squamous cell carcinoma, adenocarcinoma and vesicular nucleus cell carcinoma, is much lower ( 4 ). Most patients with NPC are sensitive to radiotherapy, which is the preferred modality of treatment ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Claudin1 promotes the proliferation, invasion and migration of nasopharyngeal carcinoma cells by upregulating the expression and nuclear entry of β‑catenin

Xiao

Zhao

et al. 2018

Exp Ther Med

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The aim of the present study was to measure the expression of Claudin (CLDN) 1 in nasopharyngeal carcinoma (NPC) and to determine its biological function and mechanism of action. Reverse transcription-quantitative polymerase chain reaction and western blotting were performed to measure the expression of CLDN1 mRNA and protein, respectively, in the immortalized human nasopharyngeal epithelial cell line NP69 and NPC-TW01 cells. Subsequently, small interfering RNA against CLDN1 and the LV-GFP-PURO-CLDN1 lentivirus were transfected into NPC-TW01 cells. Western blotting was used to determine the effects of CLDN1 down- and upregulation on the expression of the epithelial mesenchymal transition (EMT) markers E-cadherin and vimentin. In addition, the effect of CLDN1 on the expression of β-Catenin was determined. The results demonstrated that levels of CLDN1 mRNA and protein in NPC cells were significantly higher than in NP69 cells. Furthermore, the downregulation of CLDN1 inhibited the proliferation, invasion and migration of NPC-TW01 cells. The results of western blotting demonstrated that the downregulation of CLDN1 resulted in the upregulation of E-cadherin and inhibition of vimentin in NPC-TW01 cells. By contrast, the overexpression of CLDN1 resulted in the downregulation of E-cadherin and upregulation of vimentin in NPC-TW01 cells. The downregulation of β-catenin attenuated the cancer-promoting effect of CLDN1 on NPC-TW01 cells, whereas the upregulation of β-catenin reversed the tumor-suppressing effect of CLDN1 downregulation on NPC-TW01 cells. The results of the present study therefore demonstrate that CLDN1 expression is elevated in NPC cells. As an oncogene, CLDN1 promotes the proliferation, invasion and migration of NPC cells by upregulating the expression and nuclear entry of β-catenin.

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Limonin enhances the radiosensitivity of nasopharyngeal carcinoma cells via attenuating Stat3-induced cell stemness

Gao

Sang

Cao

2019

Biomedicine & Pharmacotherapy

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Comparison the clinical outcomes with altered versus conventional fractionated radiotherapy plus concurrent chemotherapy for advanced nasopharyngeal carcinoma

Abstract: Altered fractionated and conventional fractionated RT achieved similar survival outcome when concurrent CRT strategy was used for advanced NPC.

Cited by 3 publications

References 18 publications

Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Effects of Self-Care plus Forecasting Nursing on the Treatment Outcomes and Emotions in Patients with Nasopharyngeal Carcinoma after Radiotherapy

Claudin1 promotes the proliferation, invasion and migration of nasopharyngeal carcinoma cells by upregulating the expression and nuclear entry of β‑catenin

Limonin enhances the radiosensitivity of nasopharyngeal carcinoma cells via attenuating Stat3-induced cell stemness

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