Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes

Gholami, Masoumeh; Rezvanfar, Mohammad Reza; Delavar, Mostafa; Abdollahi, Mahdi; Khosrowbeygi, Ali

doi:10.1055/s-0043-124183

Cited by 18 publications

(21 citation statements)

References 51 publications

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“…A total of eleven studies were excluded for lack of full‐text availability, whilst 25 records were omitted with reasons. For example, four studies met the inclusion criteria but were excluded due to inconsistencies in data reporting. Other reasons for exclusion included reasons such as not having a clear study design, some studies were published outside the five‐year inclusion criteria, and others were excluded for not reporting on the impact of CoQ10 on individuals with diabetes or metabolic syndrome.…”

Section: Resultsmentioning

confidence: 99%

The impact of coenzyme Q₁₀ on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials

Dludla

Nyambuya

Orlando

et al. 2020

Endocrino Diabet & Metabol

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Aims: Coenzyme Q 10 (CoQ10) is well known for its beneficial effects in cardiovascular disease (CVD); however, reported evidence has not been precisely synthesized to better inform on its impact in protecting against cardiovascular-related complications in diabetic patients. Materials and Methodology:The current meta-analysis included randomized controlled trials published in the past 5 years reporting on the effect of CoQ10 on metabolic and CVD-related risk profiles in individuals with diabetes or metabolic syndrome.We searched electronic databases such as MEDLINE, Cochrane Library, Scopus and EMBASE for eligible studies. In addition to assessing the risk of bias and quality of evidence, the random and fixed-effect models were used to calculate the standardized mean difference and 95% confidence intervals for metabolic parameters and CVD outcomes. Results:Overall, 12 studies met the inclusion criteria, enrolling a total of 650 patients.Although CoQ10 supplementation did not statistically affect all metabolic profiles measured, it significantly reduced CVD-risk-related indexes such as total cholesterol and low-density lipoprotein (LDL) levels in diabetic patients when compared to those on placebo [SMD = 0.13, 95% CI (0.03; 0.23), Chi 2 = 43.62 and I 2 = 29%, P = .07]. Conclusions: The overall results demonstrated that supplementation with CoQ10shows an enhanced potential to lower CVD risk in diabetic patients by reducing total cholesterol and LDL. Moreover, the beneficial effects of CoQ10 in lowering the CVD risk are associated with its ameliorative properties against oxidative stress and improving endothelial health.

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Section: Resultsmentioning

confidence: 99%

The impact of coenzyme Q₁₀ on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials

Dludla

Nyambuya

Orlando

et al. 2020

Endocrino Diabet & Metabol

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“…With regard to the selection bias, eight RCTs [ 19 , 26 – 32 ] did not describe the randomization procedures, and twelve RCTs [ 19 , 26 – 28 , 30 – 37 ] did not describe an acceptable method of allocation concealment; thus, we thought that their risk of bias is unclear. One RCT [ 33 ] used block randomization, three RCTs [ 34 , 36 , 37 ] utilized permuted random block allocation, and one RCT used a website [ 35 ] to conduct randomization; we therefore rated them as having a low risk of bias.…”

Section: Resultsmentioning

confidence: 99%

“…Seven RCTs [ 19 , 26 , 27 , 30 , 31 , 34 , 37 ] reported TG. The random effects model was utilized due to the high heterogeneity ( τ 2 = 854.44, I 2 = 90%, P < 0.00001).…”

Section: Resultsmentioning

confidence: 99%

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Zhang

Yang

Zeng

et al. 2018

International Journal of Endocrinology

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Objective To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study's registration number is CRD42018088474. The primary outcomes included glycosylated hemoglobin, fasting blood glucose, and fasting insulin. Result Thirteen trials involving 765 patients were included. Compared with the control group, coenzyme Q10 may decrease the HbA1c (WMD −0.29; 95% CI −0.54, −0.03; P = 0.03) and the fasting blood glucose (WMD −11.21; 95% CI −18.99, −3.43; P = 0.005). For fasting insulin, there is also not strong evidence that confirms which one is better because there was no statistical difference (WMD −0.48; 95% CI −2.54, 1.57; P = 0.65). Conclusion Based on current evidence, coenzyme Q10 may assist glycemic control, decrease TG, and improve HDL-C in patients with T2DM.

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“…Overall, 730 subjects were randomly assigned in these trials, while 693 (94.9%) subjects completed the studies. Of the 14 trials used in the meta-analysis, 10 trials included both men and women,20–22,24,31,33–36,39 one included only women,38 and three did not indicate the sex composition of the sample 23,32,37. The dose of CoQ 10 varied from 100 to 400 mg/d (median, 185.7 mg/d).…”

Section: Resultsmentioning

confidence: 99%

Effects of coenzyme Q<sub>10</sub> on cardiovascular and metabolic biomarkers in overweight and obese patients with type 2 diabetes mellitus: a pooled analysis

Huang¹,

Chi²,

Liao³

et al. 2018

DMSO

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BackgroundThe potential effects of coenzyme Q10 (CoQ10) supplementation in overweight/obese patients with type 2 diabetes mellitus are not fully established. In this article, we aimed to perform a pooled analysis to investigate the effects of CoQ10 intervention on cardiovascular disease (CVD) risk factors in overweight/obese patients with type 2 diabetes mellitus (T2DM).MethodsMEDLINE, Embase, and Cochrane databases were searched for randomized controlled trials that evaluated the changes in CVD risk factors among overweight and obese patients with T2DM following CoQ10 supplementation. Two investigators independently assessed articles for inclusion, extracted data, and assessed risk of bias. Major endpoints were synthesized as weighted mean differences (WMDs) with 95% CIs. Subgroup analyses were performed to check the consistency of effect sizes across groups. Publication bias and sensitivity analysis were also performed.ResultsFourteen eligible trials with 693 overweight/obese diabetic subjects were included for pooling. CoQ10 interventions significantly reduced fasting blood glucose (FBG; −0.59 mmol/L; 95% CI, −1.05 to −0.12; P=0.01), hemoglobin A1c (HbA1c; –0.28%; 95% CI−0.53 to −0.03; P=0.03), and triglyceride (TG) levels (0.17 mmol/L; 95% CI, −0.32 to −0.03; P=0.02). Subgroup analysis also showed that low-dose consumption of CoQ10 (<200 mg/d) effectively reduces the values of FBG, HbA1c, fasting blood insulin, homeostatic model assessment of insulin resistance, and TG. CoQ10 treatment was well tolerated, and no drug-related adverse reactions were reported.ConclusionOur findings provide substantial evidence that daily CoQ10 supplementation has beneficial effects on glucose control and lipid management in overweight and obese patients with T2DM.

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Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes

Abstract: The results of the current study had shown that after supplementation with 100 mg/day of CoQ for 12 weeks, serum values of FBS, HOMA-IR, TC, LDL-C and ferritin were decreased and values of HDL-C were increased in women with T2DM.

Cited by 18 publications

References 51 publications

The impact of coenzyme Q₁₀ on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials

The impact of coenzyme Q₁₀ on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Effects of coenzyme Q<sub>10</sub> on cardiovascular and metabolic biomarkers in overweight and obese patients with type 2 diabetes mellitus: a pooled analysis

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Effects of Coenzyme Q10 Supplementation on Serum Values of Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin, and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes

Abstract: The results of the current study had shown that after supplementation with 100 mg/day of CoQ for 12 weeks, serum values of FBS, HOMA-IR, TC, LDL-C and ferritin were decreased and values of HDL-C were increased in women with T2DM.

Cited by 18 publications

References 51 publications

The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials

The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Effects of coenzyme Q<sub>10</sub> on cardiovascular and metabolic biomarkers in overweight and obese patients with type 2 diabetes mellitus: a pooled analysis

Contact Info

Product

Resources

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The impact of coenzyme Q₁₀ on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials

The impact of coenzyme Q₁₀ on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled trials