Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms

Maia-Landim, Andrea; Ramı́rez, Juan M.; Lancho, Carolina; Poblador, María S.; Lancho, José L.

doi:10.1186/s12906-018-2099-7

Cited by 37 publications

(32 citation statements)

References 39 publications

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“…Obesity has been associated with a number of conditions like fatty liver disease, osteoarthritis, digestive problems, cardiovascular disease, type II Diabetes Mellitus, and even some forms of cancer [11]. Along with its consequent comorbidities, obesity represents a socio-economic burden which has been shown to reduce life expectancy significantly.…”

Section: Discussionmentioning

confidence: 99%

Effect of Garcinia Cambogia and Green Coffee Bean in Weight Reduction

Chohan¹,

Wasim²,

Rao³

et al. 2020

Preprint

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Introduction: Various studies have widely documented how weight (being overweight, underweight or obese) plays a significant role in increasing health problems and adversely affects the quality of life. Out of all the weight-related issues, obesity is the number one contributing factor for causing health problems. To overcome this factor, a trial was conducted where a drug 'Lite plus’ (Garcinia Cambogia and Green Coffee bean) was given to a select number of people for a period of three months. Materials and Methods: 'Lite Plus' is a drug which contains Garcinia cambogia 500 mg + Green Coffee Bean Extract 400 mg, with a recommended dosage of 2 tablets/day with or before meals for 3 months. Most of the patients included in our study were females suffering from obesity-related problems such as PCOs and Infertility. During the trial, all patients were given the recommended dosage of 'Lite plus', while those with diabetes had the dose amended accordingly. Results: As a result of this trial, it was found that the use of 'Lite Plus' was very effective in decreasing weight/BMI with continuous use. After 6 weeks, out of the 250 respondents participating in the trial, 232 got a reduction in their BMI, and after 12 weeks (end of the trial), 29 respondents (11.6%) reached the desired level of BMI. Conclusion: Garcinia cambogia and Green Coffee bean are effective and safe in weight reduction.

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Section: Discussionmentioning

confidence: 99%

Effect of Garcinia Cambogia and Green Coffee Bean in Weight Reduction

Chohan¹,

Wasim²,

Rao³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…To date, several studies of the effects of lifestyle interventions among obese individuals have revealed that rs4994 C allele carriers show less weight reduction in comparison to other obese subjects [17,46,47], although several studies have shown conflicting results [48,49]. Our results suggest that in combination with the strict weight control (e.g., aimed at achieving a BMI of <23 kg/m 2 in Japanese individuals), ADRB3 rs4994 polymorphism genotyping may provide a useful information to reduce the risk of developing NAFLD in individuals with the C/C genotype.…”

Section: Discussionmentioning

confidence: 99%

Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

et al. 2019

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Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases. Obesity is the most common and well-established risk factor for NAFLD, but there are large interindividual differences in the relationship between weight status and the development of NAFLD. Beta-3-adrenergic receptor (ADRB3) plays a key role in the development of visceral obesity and insulin resistance; however, the effect of ADRB3 polymorphisms on the risk of NAFLD remains unclear. We investigated whether or not a common rs4994 polymorphism (T190C) in the ADRB3 gene is associated with the risk of NAFLD through an increase in the body mass index (BMI) among the general population. We performed cross-sectional and longitudinal analyses in a total of 591 Japanese health screening program participants. Among the overweight or obese subjects, but not normal-weight subjects, individuals with the C/C genotype had a higher risk of developing NAFLD in comparison to those with other genotypes in the cross-sectional analysis (odds ratio: 4.40, 95% confidence interval (CI): 1.08–17.93). Meanwhile, the receiver operating characteristic curve indicated that the association between an increase in the BMI and the presence of NAFLD in subjects with the C/C genotype (area under the curve: 0.91, 95% CI: 0.78–1.00) was more pronounced in comparison to subjects with other genotypes. These above-described findings were verified by the analyses using a replicated data set consisting of 5,000 random samples from original data sets. Furthermore, among the 291 subjects for whom longitudinal medical information could be collected and who did not have NAFLD at baseline, the Cox proportional hazard model also confirmed that overweight or obese status and the C/C genotype were concertedly related to the increased risk of NAFLD development. These results suggest that genotyping the ADRB3 rs4994 polymorphism may provide useful information supporting the development of personalized BMI-based preventive measures against NAFLD.

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“…Noteworthy, a prospective, non-randomized controlled trial suggested a possible beneficial role of glucomannan on weight loss in overweight subjects treated with a combination of Garcinia Cambogia and glucomannan at a dosage of 500 mg, twice a day, for six months. However, the administration in association with Garcinia Cambogia made the individual effect of GMM indistinguishable [98]. Finally, Onakpoya et al, in a systematic review and metanalysis of nine trials, indicated that glucomannan intake does not generate a significant decrease in body weight or BMI when compared to placebo [99].…”

Section: Glucomannanmentioning

confidence: 99%

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

et al. 2020

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The use of food supplements for weight loss purposes has rapidly gained popularity as the prevalence of obesity increases. Navigating through the vast, often low quality, literature available is challenging, as is providing informed advice to those asking for it. Herein, we provide a comprehensive literature revision focusing on most currently marketed dietary supplements claimed to favor weight loss, classifying them by their purported mechanism of action. We conclude by proposing a combination of supplements most supported by current evidence, that leverages all mechanisms of action possibly leading to a synergistic effect and greater weight loss in the foreseen absence of adverse events. Further studies will be needed to confirm the weight loss and metabolic improvement that may be obtained through the use of the proposed combination.

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Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms

Cited by 37 publications

References 39 publications

Effect of Garcinia Cambogia and Green Coffee Bean in Weight Reduction

Effect of Garcinia Cambogia and Green Coffee Bean in Weight Reduction

Beta-3-adrenergic Receptor rs4994 Polymorphism Is a Potential Biomarker for the Development of Nonalcoholic Fatty Liver Disease in Overweight/Obese Individuals

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

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