Sickle cell disease: An overview of orofacial and dental manifestations

Kawar, Nadia; Alrayyes, Sahar; Aljewari, Haider

doi:10.1016/j.disamonth.2017.12.004

Cited by 12 publications

(21 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We searched the medical and dental electronic databases for information on the history of prophylactic antibiotics administration, whether standard protocols for routine dental procedures (Kawar, Alrayyes, & Aljewari, 2018) were applied or whether decisions were made on a case by case basis. We found that prophylactic antibiotic precautions were followed for seven of 47 SCD patients.…”

Section: Resultsmentioning

confidence: 99%

“…However, evidence‐based guidelines to treat SCD patients were not published until the 2014 NIH recommendations (DeBaun, 2014; Yawn et al, 2014), which advocated for preventive measures to be coordinated between community healthcare, EDs, hospitals, and other specialists. Despite these recommendations, recent scientific reviews (Acharya, 2015; Kawar, Alrayyes, & Aljewari, 2018) indicated that dental treatment is often delayed in the absence of effective preventive means since the majority of individuals with SCD in the US belong to underserved, minority populations with limited access to dental care. This is a compelling issue, as many dental procedures are not covered by government‐issued insurance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predictors of dental complications post‐dental treatment in patients with sickle cell disease

Gusmini

Feng

et al. 2020

Clinical & Exp Dental Res

View full text Add to dashboard Cite

Objective Our aim was to explore potential medical or dental indicators associated with dental complications and the utilization of emergency services in sickle cell disease (SCD), especially that clinical reports on adverse outcomes post‐dental treatment are scarce. Materials and methods A retrospective analysis of dental treatments of 47 eligible adults with confirmed SCD between May 2016 and October 2019. Logistic regression analysis was used whether clinical outcomes, course of dental treatment, and regularity of dental care are associated with dental complications after dental procedures and/or resulted in emergency care or hospital admissions. Results We identified a new, statistically significant association (p‐value = .01) between the number of prescription medications taken and complications (10%) after dental procedures. The most frequent dental procedures were tooth extractions (36%) and pain management (28%) during a non‐scheduled dental encounter (68%). The majority of cases did not participate in regular recall exams and periodical oral hygiene maintenance. Conclusions A higher number of prescription medications was associated with an increased risk of post‐dental complications in SCD patients. A thorough medical history, including a list of prescribed medications, and collaboration with the patient medical team are important to assess the risk of complications post‐dental procedures and the need for antibiotic prophylaxis according to the case complexity.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Predictors of dental complications post‐dental treatment in patients with sickle cell disease

Gusmini

Feng

et al. 2020

Clinical & Exp Dental Res

View full text Add to dashboard Cite

show abstract

“…Hypoxia and the effect of this phenomenon on the neurophysiology and responsiveness of dental pulp nerve fibers have been studied in a limited study [ 23 – 27 ]. It has been shown that, in sickle cell anemia, hypoxia causes systemic complications such as local vascular contraction and periods of pain that can cause damage to vital organs [ 25 ]. In the oral cavity, the disease can cause ischemia and necrosis of the facial bones, and osteomyelitis without dental origin, especially in the mandible [ 25 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that, in sickle cell anemia, hypoxia causes systemic complications such as local vascular contraction and periods of pain that can cause damage to vital organs [ 25 ]. In the oral cavity, the disease can cause ischemia and necrosis of the facial bones, and osteomyelitis without dental origin, especially in the mandible [ 25 , 27 ]. It has also been shown that blockage of dental pulp microvasculature in healthy teeth may cause pulpal inflammation [ 25 ] and even pulpal necrosis [ 23 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Response to Pulpal Sensibility Tests (Cold, EPT) in Anemic and Healthy Women

Kazemipoor

Vatanchian

Jambarsang

et al. 2022

International Journal of Dentistry

View full text Add to dashboard Cite

Introduction. The prevalence of anemia has been reported high in the female population in Iran. Anemia can be asymptomatic or can present in a variety of symptoms, especially when serum Hb values decrease. The present study would assess dental pulp response to cold and EPT sensibility tests in anemic and healthy women. Materials and Methods. One hundred twenty maxillary central incisors belonging to participants aged 18–58 years were included in this survey. 60 patients had anemia (Hb ≤ 12.5) with/without medication (30 in each group) and 60 women as controls had no anemia (Hb > 12.5) with/without medication (30 in each group). Electric and cold pulpal sensibility tests were performed for all teeth. Statistical analysis was performed with t-student, Chi-square test, and two-way ANOVA. The significance level was set as p < 0.05 . Results. According to the results of this study, the mean value of hemoglobin in anemic and healthy women was 11.5 and 14.08 g/dl, respectively. The mean value of response to EPT in anemic women with and without medication was 3.21 and 3.14, respectively. The mean value of response to EPT in healthy women with and without medication was 3.81 and 3.58 g/dl, respectively. The mean value of time delay response to cold test was 3.03 and 2.82 s in anemic patients with/without medication. Also, the mean value of time delay response to cold test was 2.80 and 2.93 s in healthy women with/without medication. The pulpal responses to EPT tests had significant differences between anemic and healthy women ( p = 0.043 ). There were no significant differences between anemic and healthy women considering time delay response to the cold test ( p = 0.077 ). Conclusion. Based on the results of the present study, tooth response to the EPT sensibility test may alter in anemic patients despite medication. The evidence from this preliminary study suggests that peripheral neuropathy in anemic patients could affect pulpal sensibility tests.

show abstract

“…As a chronic progressive disease, SCD is a chronic vascular disorder that leads to hemolytic anemia, ongoing organ damage and susceptibility to infection, which are related to high childhood mortality, a considerable financial burden and low quality of life [5][6][7]. The characteristics of chronic low inflammation of SCD and drug treatments for the disease are considered to be associated with several oral manifestations [8].…”

Section: Introductionmentioning

confidence: 99%

Association between sickle cell disease and dental caries: a systematic review and meta-analysis

Hui

et al. 2020

Hematology

View full text Add to dashboard Cite

Objectives: Although dental caries has been widely reported in individuals with sickle cell disease (SCD), there is still controversial in the literature regarding the association between SCD and dental caries. The aim of this systematic review was to investigate whether individuals with SCD have more dental caries than individuals with non-SCD. Methods: PubMed and Embase databases were searched for eligible studies. The parameters of the permanent decayed, missing and filled teeth (DMFT) index and the permanent decayed, missing and filled surface (DMFS) index were considered as outcome measures. The overall meta-analyses of the DMFT and DMFS index and various subgroup analyses (caries components, age, and genotypes) of DMFT index were performed to calculate the weighted mean differences (WMD) between patients with SCD and non-SCD individuals. Results: A total of 9 studies covering 1478 individuals were included in this meta-analysis. The results of overall meta-analyses indicated that the scores of the DMFT and DMFS index were not significantly different between patients with SCD and non-SCD participants. The results of subgroup analyses by caries components, age, and genotypes showed no significant difference in most items. The result of the missing teeth was significantly lower in patients with SCD than in non-SCD individuals (WMD, −0.14; 95% confidence interval [CI], −0.25 to −0.03; P = 0.01). Discussion and Conclusions: The results revealed that compared with non-SCD individuals, patients with SCD did not suffer from worse dental caries. Considering the limitations, further well-designed studies are necessary to reveal the association between SCD and dental caries. KEYWORDS Sickle cell disease; sickle cell anemia; dental caries; oral health; sickle hemoglobin S; decayed, missing and filled teeth; decayed, missing and filled surface; meta-analysis

show abstract

Sickle cell disease: An overview of orofacial and dental manifestations

Cited by 12 publications

References 24 publications

Predictors of dental complications post‐dental treatment in patients with sickle cell disease

Predictors of dental complications post‐dental treatment in patients with sickle cell disease

Evaluation of the Response to Pulpal Sensibility Tests (Cold, EPT) in Anemic and Healthy Women

Association between sickle cell disease and dental caries: a systematic review and meta-analysis

Contact Info

Product

Resources

About