Effect of<i>Porphyromonas gingivalis</i>infection in the placenta and umbilical cord in pregnant mice with low birth weight

Udagawa, Sayuri; Katagiri, Seiji; Maekawa, Shogo; Takeuchi, Yasuo; Komazaki, Rina; Ohtsu, Anri; Sasaki, Naoki; Shiba, Takahiko; Watanabe, Kouichi; Ishihara, Kazuyuki; Sato, Noriko; Matsuda, Naoyuki; Izumi, Yuichi

doi:10.1080/00016357.2018.1426876

Cited by 24 publications

(29 citation statements)

References 52 publications

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“…The analysis of these mutants indicated that the presence of capsule associates with the deregulated production of pro-inflammatory cytokines by fibroblasts and macrophages, thus further supporting the idea that encapsulation is a hallmark of the virulence heterogeneity of P. gingivalis (15). P. gingivalis can destroy the periodontal tissues and distribute in different organs and tissues, where it can produce coronary and aortic atherogenesis, favor preterm birth, and deregulate the adequate metabolic control in diabetes mellitus-affected patients (16)(17)(18)(19)(20). Also, recent studies have used wild-type and transgenic mice to establish the association between P. gingivalis and Alzheimer's disease (AD)-related cognitive decline, by assessing the amyloid b (Ab) peptide accumulation and proinflammatory cytokines production, as well as the performance in spatial memory-dependent tasks in rodents orally infected with P. gingivalis (21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 69%

“…P. gingivalis can destroy the periodontal tissues and distribute in different organs and tissues, where it can produce coronary and aortic atherogenesis, favor preterm birth, and deregulate the adequate metabolic control in diabetes mellitus-affected patients ( 16 – 20 ). Also, recent studies have used wild-type and transgenic mice to establish the association between P. gingivalis and Alzheimer’s disease (AD)-related cognitive decline, by assessing the amyloid β (Aβ) peptide accumulation and pro-inflammatory cytokines production, as well as the performance in spatial memory-dependent tasks in rodents orally infected with P. gingivalis ( 21 – 25 ).…”

Section: Introductionmentioning

confidence: 99%

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Alzheimer’s Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent

Díaz‐Zúñiga

Melgar‐Rodríguez

et al. 2020

Front. Immunol.

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Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Alzheimer’s Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent

Díaz‐Zúñiga

Melgar‐Rodríguez

et al. 2020

Front. Immunol.

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“…P. gingivalis was cultivated as previously described ( Udagawa et al, 2018 ). In brief, the bacteria were maintained on trypticase soy agar (Difco Laboratories, Detroit, MI, United States) supplemented with 10% defibrinated horse blood, hemin, and menadione at 37°C under anaerobic conditions.…”

Section: Methodsmentioning

confidence: 99%

Endotoxemia by Porphyromonas gingivalis Injection Aggravates Non-alcoholic Fatty Liver Disease, Disrupts Glucose/Lipid Metabolism, and Alters Gut Microbiota in Mice

et al. 2018

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Many risk factors related to the development of non-alcoholic fatty liver disease (NAFLD) have been proposed, including the most well-known of diabetes and obesity as well as periodontitis. As periodontal pathogenic bacteria produce endotoxins, periodontal treatment can result in endotoxemia. The aim of this study was to investigate the effects of intravenous, sonicated Porphyromonas gingivalis (Pg) injection on glucose/lipid metabolism, liver steatosis, and gut microbiota in mice. Endotoxemia was induced in C57BL/6J mice (8 weeks old) by intravenous injection of sonicated Pg; Pg was deactivated but its endotoxin remained. The mice were fed a high-fat diet and administered sonicated Pg (HFPg) or saline (HFco) injections for 12 weeks. Liver steatosis, glucose metabolism, and gene expression in the liver were evaluated. 16S rRNA gene sequencing with metagenome prediction was performed on the gut microbiota. Compared to HFco mice, HFPg mice exhibited impaired glucose tolerance and insulin resistance along with increased liver steatosis. Liver microarray analysis demonstrated that 1278 genes were differentially expressed between HFco and HFPg mice. Gene set enrichment analysis showed that fatty acid metabolism, hypoxia, and TNFα signaling via NFκB gene sets were enriched in HFPg mice. Although sonicated Pg did not directly reach the gut, it changed the gut microbiota and decreased bacterial diversity in HFPg mice. Metagenome prediction in the gut microbiota showed enriched citrate cycle and carbon fixation pathways in prokaryotes. Overall, intravenous injection of sonicated Pg caused impaired glucose tolerance, insulin resistance, and liver steatosis in mice fed high-fat diets. Thus, blood infusion of Pg contributes to NAFLD and alters the gut microbiota.

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“…Being overweight or obese is associated with inflammation of the periodontal tissues as a result of the presence of inflammatory cytokines and adipokines, such as tumour necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and leptin, that are secreted by the patients’ adipose tissue 15 and cause a generalised inflammatory state in the body 16 . Some studies have highlighted that periodontitis in pregnant women has a potential association with preterm birth and low newborn weight 17–20 .…”

Section: Introductionmentioning

confidence: 99%

Periodontal status of women with excessive gestational weight gain and the association with their newborns’ health

Jesuino

Foratori‐Junior

Missio

et al. 2020

International Dental Journal

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The aim of this study was to assess the association between high gestational weight gain and systemic and periodontal status of women between the 32nd and 36th gestational weeks of pregnancy (T1) and after delivery (T2), and the association of these factors with newborns' health. Methods: The sample was divided into excessive gestational weight gain (GE = 25) and normal gestational weight gain (GN = 25) and was evaluated regarding: (i) socioeconomic status; (ii) systemic and periodontal status; and (iii) newborns' health. The results were analysed using the Mann-Whitney U-test, the t-test, the Friedman test, analysis of variance (ANOVA) and Cochran's Q test (P < 0.05). Results: Women with GE had lower household income (P = 0.010) and higher body mass index (BMI) at both T1 and T2. The prevalence of hypertension at T1 was higher in women with GE, but the condition resolved post-delivery (P = 0.001). Worsening in oral hygiene was observed at T2 in both groups (P < 0.001). Sixty-eight percent of women with GE and 16% of women with GN had periodontitis at T1, and 52% and 12%, respectively, had periodontitis at T2. In women with GE, the BMI of newborns was higher (P = 0.031). Conclusions: Women with high gestational weight gain also showed a high prevalence of hypertension and periodontitis during pregnancy, and persistent periodontitis after delivery. High gestational weight gain was related to high BMI of newborns.

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Effect ofPorphyromonas gingivalisinfection in the placenta and umbilical cord in pregnant mice with low birth weight

Abstract: Pg infection during the third trimester caused low birth weight and inflammation in the placenta and umbilical cord.

Cited by 24 publications

References 52 publications

Alzheimer’s Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent

Alzheimer’s Disease-Like Pathology Triggered by Porphyromonas gingivalis in Wild Type Rats Is Serotype Dependent

Endotoxemia by Porphyromonas gingivalis Injection Aggravates Non-alcoholic Fatty Liver Disease, Disrupts Glucose/Lipid Metabolism, and Alters Gut Microbiota in Mice

Periodontal status of women with excessive gestational weight gain and the association with their newborns’ health

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