Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm

Hirschberger, Rachel G.; Kuban, Karl; O’Shea, T. Michael; Joseph, Robert M.; Heeren, Timothy; Douglass, Laurie M.; Stafstrom, Carl E.; Jara, Hernán; Frazier, Jean A.; Hirtz, Deborah; Rollins, Julie V.; Paneth, Nigel; Ware, Janice; Coster, Taryn; Hanson, Brandi; Wilson, Rachel; McGhee, Kirsten; Lee, Patricia; Asgarian, Aimee; Sadhwani, Anjali; Perrin, Ellen C.; Neger, Emily; Mattern, Kathryn; Walkowiak, Jenifer; Barron, Susan; Shah, Bhavesh; Singh, Rachana; Smith, Anne; Klein, Deborah; McQuiston, Susan; Venuti, Lauren; Powers, Beth; Foley, Ann; Dessureau, Brian; Wood, Margaret; Damon-Minow, Jill; Ehrenkranz, Richard A.; Benjamin, Jennifer; Romano, Elaine; Tsatsanis, Kathy; Chawarska, Katarzyna; Kim, Sophy; Dieterich, Susan; Bearrs, Karen; Peters, Nancy; Brown, Patricia; Ansusinha, Emily; Waldrep, Ellen; Friedman, Jackie; Hounshell, Gail; Allred, Debbie; Engelke, Stephen C.; Darden‐Saad, Nancy; Stainback, Gary; Warner, Diane; Wereszczak, Janice; Bernhardt, Janice; McKeeman, Joni; Meyer, Eugene; Pastyrnak, Steve; Rathbun, Julie; Nota, Sarah; Crumb, Teri; Lenski, Madeleine; Weiland, Deborah; Lloyd, Megan; Hunter, Scott J.; Msall, Michael E.; Ramoskaite, Rugile; Wiggins, Suzanne; Washington, Krissy; Martin, Ryan J.; Prendergast, Barbara; Scott, Megan; Klarr, Judith; Kring, Beth; DeRidder, Jennifer; Vogt, Kelly

doi:10.1016/j.pediatrneurol.2017.11.002

Cited by 53 publications

(22 citation statements)

References 53 publications

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“…A recent study by Hirschberger et al investigated the prevalence of neurodevelopmental impairments in children aged 10 who were born extremely preterm. 47 A total of 93 out of 849 children (11%) had CP, 8 (20%) of whom presented with comorbid ASD. At age ten years, children who had been diagnosed with CP at age two years had a þ1.71 risk of having ASD compared with children without CP.…”

Section: Comorbidity Of Cp and Asdmentioning

confidence: 99%

A systematic review of comorbidity between cerebral palsy, autism spectrum disorders and Attention Deficit Hyperactivity Disorder

Craig

Savino

Trabacca

2019

European Journal of Paediatric Neurology

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The aim of this systematic review was to examine the incidence and prevalence of comorbidity between Cerebral Palsy (CP), Autism spectrum disorders (ASDs) and Attention-Deficit/Hyperactivity Disorder (ADHD). Methods: We searched for articles indexed in PubMed, EBSCOhost, Scopus, Web of Science and other potentially relevant internet sources using a combination of expressions including "cerebral palsy" AND "autism" OR "ASD" OR "pervasive development disorder" AND "Attention Deficit Hyperactivity Disorder" OR "ADHD". Results: We identified 2542 studies on CP and ASD and 998 studies on CP and ADHD. After screening titles and abstracts and removing duplicated studies, 47 full papers (CP and ASD n ¼ 28; CP and ADHD n ¼ 19) were downloaded and screened for eligibility. Twenty-eight (CP and ASD n ¼ 16; CP and ADHD n ¼ 12) studies were identified in the peer-review literature. Based on this systematic review, ASD and ADHD seem to be more common in people with CP than in the general population, yet the gold standard methods for diagnosing ASD or ADHD are not suitable for children with motor problems. Conclusions: Assessing the occurrence of ASD and ADHD would improve the significant cost of healthcare, therapies, and overall daily living for families with children affected by CP. However, psychometric studies are needed in the future to promote development of measures suitable for individuals with CP. In addition, this review highlights the paucity of peer-reviewed studies investigating the occurrence of ASD and ADHD in children with different CP subtypes or functional abilities, and there are still some open questions about pathogenic mechanisms common to CP, ASD and ADHD.

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Section: Comorbidity Of Cp and Asdmentioning

confidence: 99%

A systematic review of comorbidity between cerebral palsy, autism spectrum disorders and Attention Deficit Hyperactivity Disorder

Craig

Savino

Trabacca

2019

European Journal of Paediatric Neurology

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“…Other neurological conditions (epilepsy, cerebral palsy etc.) are common in autism [30,31] and we found they have effects on the important determinant of short-term outcome.…”

Section: Discussionmentioning

confidence: 73%

Use of machine learning methods in prediction of short-term outcome in autism spectrum disorders

Usta

Karabekiroğlu

Şahin

et al. 2018

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: Studies show partial improvements in some core symptoms of Autism Spectrum Disorders (ASD) in time. However, the predictive factors (e.g. pretreatment IQ, comorbid psychiatric disorders, adaptive, and language skills, etc.) for a better the outcome was not studied with machine learning methods. We aimed to examine the predictors of outcome with machine learning methods, which are novel computational methods including statistical estimation, information theories and mathematical learning automatically discovering useful patterns in large amounts of data. METHOD: The study the group comprised 433 children (mean age: 72.3 ± 45.9 months) with ASD diagnosis. The ASD symptoms were assessed by the Autism Behavior Checklist, Aberrant Behavior Checklist, Clinical Global Impression scales at baseline (T0) and 12th (T1), 24th (T2), and 36th (T3) months. We tested the performance of for machine learning algorithms (Naive Bayes, Generalized Linear Model, Logistic Regression, Decision Tree) on our data, including the 254 items in the baseline forms. Patients with ≤2 CGI points in ASD symptoms at in 36 months were accepted as the group who has "better outcome" as the prediction class. RESULTS: The significant proportion of the cases showed significant improvement in ASD symptoms (39.7% in T1, 60.7% in T2; 77.8% in T3). Our machine learning model in T3 showed that diagnosis group affected the prognosis. In the autism group, older father and mother age; in PDD-NOS group, MR comorbidity, less birth weight and older age at diagnosis have a worse outcome. In Asperger's Disorder age at diagnosis, age at first evaluation and developmental cornerstones has affected prognosis. CONCLUSION: In accordance with other studies we found early age diagnosis, early start rehabilitation, the severity of ASD symptoms at baseline assessment predicted outcome. Also, we found comorbid psychiatric diagnoses are affecting the outcome of ASD symptoms in clinical observation. The machine learning models reveal several others are more significant (e.g. parental age, birth weight, sociodemographic variables, etc.) in terms of prognostic information and also planning treatment of children with ASD.

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“…It is likely that the brain and retina share similar types of vascular patterns (Allred et al., 2014; Gogat et al., 2004; Hirschberger et al., 2018; Ludwig, Chen, Hernandez‐Boussard, Moshfeghi, & Moshfeghi, 2017). Therefore, ROP, a disorder of dysregulated retinal angiogenesis, is potentially a reasonable proxy for dysregulated neuro‐angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Associations between VEGF isoforms and impending retinopathy of prematurity

Movsas

Muthusamy

2020

Intl J of Devlp Neuroscience

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Background/Objective Vascular Endothelial Growth Factor (VEGF) is the main driver of angiogenesis during neurodevelopment (i.e., brain and retina). VEGF165 and VEGF121 are the two most prevalent human VEGF isoforms. Although retinopathy of prematurity (ROP), a neuroretinal disorder, is associated with VEGF dysregulation, little is known about the interaction of VEGF isoforms on neuroretinal angiogenesis. We hypothesized that: (a) A specific VEGF165/VEGF121 correlation, at a given time point, is associated with normal retinal development (no ROP) and (b) An altered correlation, of such, is associated with aberrant retinal development (ROP). Utilizing pre‐collected dried blood spots (DBS) from <1‐week‐old preterm infants, we aimed to determine whether correlations between VEGF165 and VEGF121 precede the diagnosis of early stage, non‐proliferative ROP (NP‐ROP). Methodology We conducted a case/control study, utilizing DBS from 65 preterm infants. We measured DBS levels of VEGF165 on the Mesoscale Discovery Platform and VEGF121 via Cloud Clone Elisa Assay. Results In infants with NP‐ROP, VEGF165 is significantly higher in males (than females). In infants without ROP, there is a significant correlation between VEGF165 and VEGF121 in females (but not males). In infants with NP‐ROP, the opposite is so; there is a significant correlation between VEGF165 and VEGF121 in males (but not females). Conclusions This pilot study, utilizing de‐identified data, suggests the potential importance of examining interactions between VEGF isoforms, at <1 week after birth, to better understand ROP development. Our study also suggests that retinal angiogenesis may not be a sex‐neutral process. A prospective study is needed to confirm our novel findings.

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Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm

Abstract: Three quarters of children had normal intellect at age ten years; nearly 70% were free of neurodevelopmental impairment. Forty percent of children with impairments had multiple diagnoses.

Cited by 53 publications

References 53 publications

A systematic review of comorbidity between cerebral palsy, autism spectrum disorders and Attention Deficit Hyperactivity Disorder

A systematic review of comorbidity between cerebral palsy, autism spectrum disorders and Attention Deficit Hyperactivity Disorder

Use of machine learning methods in prediction of short-term outcome in autism spectrum disorders

Associations between VEGF isoforms and impending retinopathy of prematurity

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