A brief look at the role of monocyte chemoattractant protein-1 (CCL2) in the pathophysiology of psoriasis

Behfar, Shadi; Hassanshahi, Gholamhossein; Nazari, Alireza; Khorramdelazad, Hossein

doi:10.1016/j.cyto.2017.12.010

Cited by 68 publications

(41 citation statements)

References 77 publications

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“…We also demonstrated that the tested LAB lysates were able to decrease the secretion from HaCaT cells of other specific pro-inflammatory factors, such as MCP-1. It is known that the keratinocyte production of MCP-1 plays a key role in psoriasi 32 and other skin disorders such as atopic and contact dermatitis 33,34 . Interestingly, we found that the secretion of MCP-1 from keratinocytes was induced after stimulation with heat-killed S. pyogens, but reverted and reduced by treatment with L. paracasei SGL 04, L. plantarum 07 and L. salivarius SGL 19 lysates.…”

Section: Discussionmentioning

confidence: 99%

Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes

Brandi

Cheri

Manfredi

et al. 2020

Sci Rep

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The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve skin health. This work aims to characterize by a multidisciplinary approach, the wound healing, anti-inflammatory, anti-pathogens and proteomic effects of six LAB lysates, belonging to the genus Lactobacillus. Our results demonstrated that the lysates of tested LAB stimulated the proliferation of keratinocytes, and that L. plantarum SGL 07 and L. salivarius SGL 19 accelerated the re-epithelization by inducing keratinocyte migration. The bacterial lysates also reduced the secretion of specific pro-inflammatory mediators from keratinocytes. Furthermore, viable L. salivarius SGL 19 and L. fermentum SGL 10 had anti-pathogenic effects against S. aureus and S. pyogenes, while L. brevis SGL 12 and L. paracasei SGL 04 inhibited S. aureus and S. pyogenes, respectively. The tested lactobacilli lysates also induced specific proteome modulation of the exposed keratinocytes, involving dysregulation of proteins (such as interleukin enhancer-binding factor 2 and ATP-dependent RNA helicase) and pathways (such as cytokine, NF-kB, Hedgehog, and RUNX signaling) associated with their specific wound healing and anti-inflammatory effects. This study indicates the different potential of selected lactobacilli, suggesting that they may be successfully used in the future together with conventional therapies to bring relief from skin disorders. Abbreviations LAB Lactic acid bacteria TNF-α Tumor necrosis factor-alpha IFN-γ Interferon-gamma PBS Phosphate buffered saline DMEM Dulbecco's modified Eagle's medium MCP-1 Monocyte chemoattractant protein-1 RANTES Regulated on activation, normal T cell expressed and secreted LC-MS/MS Liquid chromatography-tandem mass spectrometry SWATH Sequential window acquisition of all theoretical mass spectra The skin, considered the largest organ of the body, is involved in a variety of functions and acts primarily as a protective barrier preventing the entry of potential pathogens. In particular, skin homeostasis is regulated by microorganisms, the so called skin microbiota, which act on keratinocytes and on their cytokine release, ensuring

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Section: Discussionmentioning

confidence: 99%

Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes

Brandi

Cheri

Manfredi

et al. 2020

Sci Rep

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“…Studies on patients infected with CoV (that is, SARS-CoV, MERS-CoV, and SARS-CoV-2) have shown that lymphopenia and cytokine storms are two significant immunopathologic findings in these patients [ [57] , [58] , [59] ]. Cytokine storms also occur due to impaired expression and production of inflammatory cytokines such as IL-1β, IL-4, IL-6, IL-10, IL-18 IL-33, IFN-γ, and TNF-a that can result in increased and uncontrolled inflammation and sometimes damage various tissues and organs [ [60] , [61] , [62] ]. This devastating immune phenomenon is typically observed in disorders such as viral infections, bacterial septic shock, ARDS, drug toxicity, autoimmune diseases, and also following chimeric antigen receptor T (CAR-T) cell therapy [ [63] , [64] , [65] ].…”

Section: Role Of Il-6 In Covid-19 Pathogenesismentioning

confidence: 99%

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

Abbasifard

Khorramdelazad

2020

Life Sciences

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Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel coronavirus disease 2019 (COVID-19) has recently received much more attention due to the spread of the virus and its pandemic potential. Cytokine storm is among the most critical pathological events in patients affected with coronaviruses (CoVs), i.e., severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and COVID-19, causing inflammation-induced lung injury and also occurring as a result of dysregulation of immune responses to the mentioned viruses. IL-6, along with some other inflammatory cytokines, including IL-1 beta (β), IL-8, and tumor necrosis factor-alpha (TNF-α), as well as inflammatory chemokines, can significantly contribute to, fever, lymphopenia, coagulation, lung injury, and multi-organ failure (MOF). Therefore, researchers are to explore novel approaches to treat the disease through targeting of IL-6 and its receptors based on prior experience of other disorders. In this review article, the latest findings on the role of IL-6 in the pathogenesis of COVID-19, as well as therapeutic perspectives, were summarized and discussed.

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“…CCL2 is a member of the CC chemokine family and is a chemotactic factor for monocytes/macrophages. Not only monocytes themselves but also astrocytic cells, endothelial cells, keratinocytes, mesangial cells, smooth muscle cells, microglial cells, and fibroblasts can produce CCL2 [99]. CCL2 is known as a downstream gene of the type I IFN pathway [100].…”

Section: Resultsmentioning

confidence: 99%

Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome

Cassius

Buanec

Bouaziz

et al. 2019

Journal of Immunology Research

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Dermatomyositis pathophysiology is complex. In recent years, medical research has identified molecules associated with disease activity. Besides providing insights into the driving mechanisms of dermatomyositis, these findings could provide potential biomarkers. Activity markers can be used to monitor disease activity in clinical trials and may also be useful in daily practice. This article reviews molecules that could be used as biomarkers for diagnosis and monitoring dermatomyositis disease activity.

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A brief look at the role of monocyte chemoattractant protein-1 (CCL2) in the pathophysiology of psoriasis

Cited by 68 publications

References 77 publications

Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes

Exploring the wound healing, anti-inflammatory, anti-pathogenic and proteomic effects of lactic acid bacteria on keratinocytes

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

Biomarkers in Adult Dermatomyositis: Tools to Help the Diagnosis and Predict the Clinical Outcome

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