Evaluation of Retinal Nerve Fiber Layer Thinning in Myopic Glaucoma: Impact of Optic Disc Morphology

Na, Kyeong Ik; Lee, Won June; Kim, Young Kook; Park, Ki Ho; Jeoung, Jin Wook

doi:10.1167/iovs.17-22534

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…For instance, Sung et al ( 107 ) found that the presence of optic disc torsion with a visual field defect at the corresponding region was a protective factor against visual field progression (HR = 0.441, P = 0.016). On the contrary, Na et al ( 108 ) found that eyes with visual field defect that corresponded to the direction of disc torsional had a faster visual field progression rate than eyes with no disc torsion or had visual field defect that did not correspond to the direction of disc torsion. They pointed out that their participants were older than those in the Sung et al’s ( 107 ) study (57.17 ± 10.43 years vs. 37.83 ± 10.89 years), with their nerve fibers likely to be more vulnerable to damage.…”

Section: Functional Changes Related To Myopic Tilted Discmentioning

confidence: 97%

“…Despite the known correlation between optic disc torsion and the location of visual field defect, the association between disc torsion and visual field progression remains controversial. Different studies suggested that disc torsion was associated with lower risk (100, 106, 107) or higher risk (26,108,109) of visual field progression, although others did not find any relationship between the two (98,102). For instance, Sung et al (107) found that the presence of optic disc torsion with a visual field defect at the corresponding region was a protective factor against visual field progression (HR = 0.441, P = 0.016).…”

Section: Longitudinal Studiesmentioning

confidence: 99%

“…They pointed out that their participants were older than those in the Sung et al’s ( 107 ) study (57.17 ± 10.43 years vs. 37.83 ± 10.89 years), with their nerve fibers likely to be more vulnerable to damage. It was also possible that the functional loss due to RNFL defect might only reveal at an older age ( 108 ). In a Korean study myopic eyes with disc torsion greater than 15 degrees from the vertical meridian showed a faster progression rate than other myopic eyes ( 109 ), with the visual field defect limited to a single hemisphere even after 10 years of follow-up ( 109 ).…”

Section: Functional Changes Related To Myopic Tilted Discmentioning

confidence: 99%

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Myopic tilted disc: Mechanism, clinical significance, and public health implication

2023

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Myopic tilted disc is a common structural change of myopic eyes. With advancing ocular imaging technology, the associated structural changes of the eye, particularly the optic nerve head, have been extensively studied. These structural changes may increase patients’ susceptibility to axonal damage and the risk of developing serious optic neuropathies including glaucoma. They also lead to diagnostic difficulties of disease suspects and treatment dilemmas of patients, which implicate clinical practice and subsequently the health care system. In the context of the mounting prevalence of myopia worldwide and its implications to irreversible visual impairment and blindness, it is essential to gain a thorough understanding of the structural changes of myopia. Myopic tilted disc has been extensively investigated by different study groups. However, generalizing the knowledge could be difficult because of the variable definitions of myopic tilted disc utilized in these studies and the complexities of the changes. The current review aimed to clarify the concepts and discuss various aspects of myopic tilted disc, including the definitions, association with other myopia-related changes, mechanism of tilted disc development, structural and functional changes, and clinical implications.

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Section: Functional Changes Related To Myopic Tilted Discmentioning

confidence: 97%

Section: Longitudinal Studiesmentioning

confidence: 99%

Section: Functional Changes Related To Myopic Tilted Discmentioning

confidence: 99%

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Myopic tilted disc: Mechanism, clinical significance, and public health implication

2023

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“…Methodologic details on the calculation of thinning rates have been described previously, 11,14 and we modified the method. In brief, the linear mixed model analysis was performed for GCIPL or RNFL thickness to determine the rate of change in thickness (expressed in micrometers per year).…”

Section: Calculation Of Cirrus Hd-oct Gcipl and Rnfl Thickness Thinnimentioning

confidence: 99%

Rates of Ganglion Cell-Inner Plexiform Layer Thinning in Normal, Open-Angle Glaucoma and Pseudoexfoliation Glaucoma Eyes: A Trend-Based Analysis

Lee

Baek

Kim

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to determine the rate of ganglion cell-inner plexiform layer (GCIPL) thinning by Cirrus high-definition optical coherence tomography (HD-OCT) in normal eyes and open-angle glaucoma (OAG) and pseudoexfoliation glaucoma (PXG) eyes. METHODS. This was a longitudinal observational study. We evaluated 282 subjects who visited a glaucoma clinic of a tertiary hospital in Korea: 60 healthy eyes, 193 medically treated OAG eyes, and 29 medically treated PXG eyes with a minimum 3-year follow-up involving serial spectral-domain OCT measurement of GCIPL thickness. The rates of thinning in the GCIPL thickness of the global region, six macular sectors, and minimum thickness were determined by linear mixed model and compared among the normal, OAG, and PXG groups. Additionally, the GCIPL thinning rates were compared between normal-baseline-IOP OAG (normal-tension glaucoma [NTG]) and high-baseline-IOP OAG (high-tension glaucoma [HTG]) eyes. RESULTS. The mean rates of GCIPL thinning were À0.31 lm/y in the normal eyes, À0.49 lm/y in OAG, and À1.46 lm/y in PXG. The differences in the mean GCIPL thinning rates were statistically significant between OAG and PXG (normal versus OAG, P ¼ 0.231; OAG versus PXG, P < 0.001; normal versus PXG, P < 0.001). Among the eyes with OAG, the treated NTG and HTG eyes showed no significant difference in GCIPL thinning rate (NTG versus HTG ¼ À0.41 lm/y versus À0.66 lm/y, P ¼ 0.123). CONCLUSIONS. We determined the GCIPL thinning rates for normal and undertreated OAG and PXG eyes. Differences existed among the normal eyes and glaucoma types, with PXG progressing significantly faster than OAG.

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“…Glaucoma is a chronic and progressive disease affecting the structures of the eye, leading to the optic nerve atrophy, to apoptosis of retinal ganglion cells (RGCs), and finally to loss of vision [1][2][3]. It has also been reported that a common feature of glaucoma is a thinning of the retinal nerve fibre layer as well as cupping of the optic disc [4][5][6][7]. According to the morphology of the anterior chamber angle, glaucoma may by subdivided into open-angle glaucoma (OAG) and angle-closure glaucoma (ACG) [8,9].…”

Section: Introductionmentioning

confidence: 99%

The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma

Rozpędek‐Kamińska

Wojtczak

Szaflik

et al. 2020

IJMS

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Glaucoma is a heterogenous, chronic, progressive group of eye diseases, which results in irreversible loss of vision. There are several types of glaucoma, whereas the primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma, accounting for three-quarters of all glaucoma cases. The pathological mechanisms leading to POAG pathogenesis are multifactorial and still poorly understood, but it is commonly known that significantly elevated intraocular pressure (IOP) plays a crucial role in POAG pathogenesis. Besides, genetic predisposition and aggregation of abrogated proteins within the endoplasmic reticulum (ER) lumen and subsequent activation of the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-dependent unfolded protein response (UPR) signaling pathway may also constitute important factors for POAG pathogenesis at the molecular level. Glaucoma is commonly known as a ‘silent thief of sight’, as it remains asymptomatic until later stages, and thus its diagnosis is frequently delayed. Thereby, detailed knowledge about the glaucoma pathophysiology is necessary to develop both biochemical and genetic tests to improve its early diagnosis as well as develop a novel, ground-breaking treatment strategy, as currently used medical therapies against glaucoma are limited and may evoke numerous adverse side-effects in patients.

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Evaluation of Retinal Nerve Fiber Layer Thinning in Myopic Glaucoma: Impact of Optic Disc Morphology

Abstract: Our results suggest that the optic disc torsion-glaucomatous damage correspondence is an important prognostic factor for patients with myopic open-angle glaucoma.

Cited by 9 publications

References 34 publications

Myopic tilted disc: Mechanism, clinical significance, and public health implication

Myopic tilted disc: Mechanism, clinical significance, and public health implication

Rates of Ganglion Cell-Inner Plexiform Layer Thinning in Normal, Open-Angle Glaucoma and Pseudoexfoliation Glaucoma Eyes: A Trend-Based Analysis

The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma

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