Is there a pathogenetic link between frontal fibrosing alopecia, androgenetic alopecia and fibrosing alopecia in a pattern distribution?

Katoulis, Alexander; Diamanti, Konstantina; Sgouros, Dimitrios; Liakou, Aikaterini I.; Bozi, Evangelia; Avgerinou, Georgia; Panayiotides, Ioannis G.; Rigopoulos, Dimitrios

doi:10.1111/jdv.14748

Cited by 20 publications

(29 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another interesting finding was the increasing number of patients diagnosed with FAPD (57 cases, 6.8% of cicatricial alopecias). This entity was described by Zinkernagel and Trüeb in 2000 [18] and has been rarely reported in other epidemiological studies [14,21,24,25] being probably underdiagnosed. In our study, FAPD patients were predominantly females (89%) with a median age of 59 years, which is in concordance with earlier reports (Zinkernagel and Trüeb [18]: 19 patients, 79% females, median age 60 years; Mardones et al [26]: 12 cases, 70% females, median age 48 years).…”

Section: Discussionmentioning

confidence: 92%

Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study

Vañó‐Galván

Saceda‐Corralo

Blume-Peytavi

et al. 2019

Skin Appendage Disord

View full text Add to dashboard Cite

Background: The frequency of different types of alopecia is not clearly reported in recent studies. Objective: To analyze the frequency of the types of alopecia in patients consulting at specialist hair clinics (SHC) and to assess for global variations. Methods: Multicenter retrospective study including data from patients evaluated at referral SHC in Europe, America, Africa and Australia. Results: A total of 2,835 patients (72.7% females and 27.3% males) with 3,133 diagnoses of alopecia were included (73% were non-cicatricial and 27% were cicatricial alopecias). In all, 57 different types of alopecia were characterized. The most frequent type was androgenetic alopecia (AGA) (37.7%), followed by alopecia areata (AA) (18.2%), telogen effluvium (TE) (11.3%), frontal fibrosing alopecia (FFA) (10.8%), lichen planopilaris (LPP) (7.6%), folliculitis decalvans (FD) (2.8%), discoid lupus (1.9%) Vañó-Galván et al.

show abstract

Section: Discussionmentioning

confidence: 92%

Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study

Vañó‐Galván

Saceda‐Corralo

Blume-Peytavi

et al. 2019

Skin Appendage Disord

View full text Add to dashboard Cite

show abstract

“…Androgen-related cause has been proposed, based on its clinical localization, the predominance of perimenopausal women and the clinical improvement with antiandrogen therapy. 43 However, until now, there has been no strong supporting evidence on this matter. The sex hormone levels of FFA patients in most published studies indicates normal values for menopause.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics, trichoscopy, histopathology and treatment outcomes of frontal fibrosing alopecia in an Asian population: A retro‐prospective cohort study

Panchaprateep

Ruxrungtham

Chancheewa

et al. 2020

The Journal of Dermatology

View full text Add to dashboard Cite

Frontal fibrosing alopecia (FFA) is a distinctive lymphocytic scarring alopecia with rapid increase in prevalence. Most FFA series are retrospectively reported from Caucasians with only few from Asians. The objective of this study was to characterize the clinical, trichoscopic and histopathological findings as well as treatment outcomes. This was a retro‐prospective cohort study of patients diagnosed with FFA from 1 January 2010 to 1 November 2019. All patients were asked to present for re‐examination. Clinical, trichoscopic, histopathological and laboratory data were recorded. A questionnaire was used to investigate hair care, hairstyle and facial skin care compared with age‐matched normal controls. Multivariate analysis was performed in order to clarify factors associated with severity. All 58 FFA patients were female, of whom 27.6% were premenopausal, 37.7% had a history of surgical menopause, 13.8% had thyroid diseases, 69% had eyebrow loss and 32.8% facial papules. On physical examination, 10.3% showed linear pattern, 46.6% diffuse pattern and 43.1% pseudo‐fringe sign. Concomitant lichen planopilaris was found in 25.9%, lichen planus pigmentosus in 24.1% and female pattern hair loss in 48.3%. The most common trichoscopic characteristics in the frontal hairline were lack of follicular ostia (91.4%), perifollicular scales (79.3%) and perifollicular erythema (63.8%). Up to 90% of patients reported FFA as improved or stable after receiving antiandrogen (finasteride or dutasteride) or antimalarial with topical treatment. Multivariate analyses revealed that facial lentiginous macules and trichoscopic perifollicular erythema at the frontal area were FFA severity‐associated factors. “Front puff” Thai hairstyle was associated with FFA, while sunscreens and other cosmetic products were not. In conclusion, diffuse and pseudo‐fringe sign pattern are common in Asian FFA. The most common autoimmune systemic comorbidity is thyroid disease, while common concomitant dermatological diseases are female pattern hair loss, lichen planopilaris and lichen planus pigmentosus. Antiandrogens or antimalarial plus topical treatment are the most useful therapy.

show abstract

“…FFA and FAPD are both classified as subtypes of LPP by many authorities,3, 4 although this classification is still debatable 5 . CPHL, as described by Olsen, 1 is also a relatively new entity similar to FAPD but lacking the perifollicular erythema and perifollicular keratosis seen in FAPD.…”

Section: Discussionmentioning

confidence: 99%

Rapidly progressive diffuse fibrosing alopecia

Zhu

et al. 2019

JAAD Case Reports

View full text Add to dashboard Cite

Is there a pathogenetic link between frontal fibrosing alopecia, androgenetic alopecia and fibrosing alopecia in a pattern distribution?

Cited by 20 publications

References 9 publications

Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study

Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study

Clinical characteristics, trichoscopy, histopathology and treatment outcomes of frontal fibrosing alopecia in an Asian population: A retro‐prospective cohort study

Rapidly progressive diffuse fibrosing alopecia

Contact Info

Product

Resources

About