Theranostic liposomes as a bimodal carrier for magnetic resonance imaging contrast agent and photosensitizer

Skupin-Mrugalska, Paulina; Sobotta, Łukasz; Warowicka, Alicja; Wereszczyńska, Beata; Zalewski, Tomasz; Gierlich, Piotr; Jarek, Marcin; Nowaczyk, Grzegorz; Kempka, M.; Gapiński, Jacek; Jurga, Stefan; Mielcarek, Jadwiga

doi:10.1016/j.jinorgbio.2017.11.025

Cited by 39 publications

(21 citation statements)

References 54 publications

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“…Gadolinium-based contrast agents can be incorporated into nanoparticles to enable real-time imaging of their in vivo biodistribution using MRI. A number of nanoparticle types have incorporated these contrast agents, including liposomes (Unger et al, 1989 ; Saito et al, 2005 ; Hossann et al, 2013 ; Smith et al, 2013 ; Skupin-Mrugalska et al, 2018 ), dendrimers (Margerum et al, 1997 ; Lee et al, 2005 ; Rongzuo et al, 2007 ), micelles (Parac-Vogt Tatjana et al, 2004 ; Kumar et al, 2010 ), polymeric-based nanoparticles (Liu et al, 2011 ), carbon-based nanotubes (Hartman et al, 2008 ; Richard et al, 2008 ), and mesoporous silica nanoparticles (Kobayashi et al, 2007 ; Kim et al, 2008 ; Taylor et al, 2008 ). For example, Saito et al ( 2005 ) manufactured gadoteridol-loaded liposomes for real-time MRI evaluation of convection-enhanced delivery in the primate brain.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

“…The results showed that MRI of liposomal gadolinium was highly accurate at determining tissue distribution, as confirmed by comparison with histological results from concomitant administration of fluorescent liposomes. Gadolinium-based contrast agents can be incorporated within the core of nanoparticles, attached to the particle surface, or inserted into the carrier membrane (Unger et al, 1989 ; Hossann et al, 2013 ; Smith et al, 2013 ; Skupin-Mrugalska et al, 2018 ). It should be noted that encapsulation of gadolinium within the core can lead to lowered relaxivity, whereas surface attachment may be preferable to improve gadolinium's ability to interact with water (Tilcock et al, 1989 ; Kamaly and Miller, 2010 ).…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

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Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles

Arms

Flynn

et al. 2018

Front. Pharmacol.

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Nanomedicines are typically submicrometer-sized carrier materials (nanoparticles) encapsulating therapeutic and/or imaging compounds that are used for the prevention, diagnosis and treatment of diseases. They are increasingly being used to overcome biological barriers in the body to improve the way we deliver compounds to specific tissues and organs. Nanomedicine technology aims to improve the balance between the efficacy and the toxicity of therapeutic compounds. Nanoparticles, one of the key technologies of nanomedicine, can exhibit a combination of physical, chemical and biological characteristics that determine their in vivo behavior. A key component in the translational assessment of nanomedicines is determining the biodistribution of the nanoparticles following in vivo administration in animals and humans. There are a range of techniques available for evaluating nanoparticle biodistribution, including histology, electron microscopy, liquid scintillation counting (LSC), indirectly measuring drug concentrations, in vivo optical imaging, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine imaging. Each technique has its own advantages and limitations, as well as capabilities for assessing real-time, whole-organ and cellular accumulation. This review will address the principles and methodology of each technique and their advantages and limitations for evaluating in vivo biodistribution of nanoparticles.

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Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles

Arms

Flynn

et al. 2018

Front. Pharmacol.

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“…in cancer treatment [8][9][10][11]. The range of liposomes applications has been expanded by the incorporation of gadolinium in their structure, converting them into paramagnetic systems useful as MRI contrast agent [12][13][14]. The insertion of gadolinium in liposomes paved the way to construct multimodal particles with joined diagnostic…”

Section: Liposomes As Mri Camentioning

confidence: 99%

“…Taking into account a wide range of currently available types of lipids, there is a large number of possible liposome compositions with various physicochemical properties [8,14]. Paramagnetic liposomes intended for use in MRI are obtained either by placing a hydrophilic gadolinium chelate in the aqueous lumen of a liposome [8], or through the incorporation of gadolinium-functionalized amphiphilic lipids in the lipid bilayer [8,[12][13][14]. In the first case, the relaxation effect is clearly visible only after increasing the permeability of the lipid membrane at nanoparticles destination site.…”

Section: Liposomes As Mri Camentioning

confidence: 99%

The Positive Influence of Therapeutic Agent on Relaxivities of Gadolinium-Loaded Liposomal Theranostics

Wereszczyńska

Zalewski

2020

Appl Magn Reson

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This study investigates changes in the MRI contrast properties of Gd(III)-containing paramagnetic liposomes following the incorporation of photosensitizing agent (ZnPc—zinc phthalocyanine). It provides identification of mechanisms responsible for enhancement of proton relaxation rate and hence, the increased both r1 and r2 relaxivities. Five liposomal formulations, containing fatty acids derivatives of Gd(III) salt and hydrophobic ZnPc, were synthesized. NMRD profiles of liposomal solutions (magnetic field range from 0.0002 to 9.4 T) were obtained and Modified Florence model was applied. The contrast properties of the model drug itself was separated from the lipid bilayer deformation influence, caused by its incorporation. The latter resulted, among other, in optimization of an apparent water exchange correlation time. As Gd(III) is located in the outer and inner lipid layers, some of the Gd(III) chelates are localized in aqueous interior of the liposomes, thus their contrasting efficiency depends on the water exchange rate through the membrane. The proposed approach raises the possibility of reducing the amount of potentially harmful contrast media based on gadolinium, by taking into account the increase of the relaxation effect caused by other components of the system.

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“…This liposome showed enhanced contrast properties in the presence of pegylated phospholipid by increased the water proton nearby gadolinium. Indeed, cell viability of hela cell was significantly inhibited under laser exposure [ 100 ].…”

Section: Introductionmentioning

confidence: 99%

Theranostics and contrast agents for magnetic resonance imaging

Jeong¹,

Hwang²,

Na³

2018

Biomater Res

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BackgroundMagnetic resonance imaging is one of the diagnostic tools that uses magnetic particles as contrast agents. It is noninvasive methodology which provides excellent spatial resolution. Although magnetic resonance imaging offers great temporal and spatial resolution and rapid in vivo images acquisition, it is less sensitive than other methodologies for small tissue lesions, molecular activity or cellular activities. Thus, there is a desire to develop contrast agents with higher efficiency. Contrast agents are known to shorten both T1 and T2. Gadolinium based contrast agents are examples of T1 agents and iron oxide contrast agents are examples of T2 agents. In order to develop high relaxivity agents, gadolinium or iron oxide-based contrast agents can be synthesized via conjugation with targeting ligands or functional moiety for specific interaction and achieve accumulation of contrast agents at disease sites.Main bodyThis review discusses the principles of magnetic resonance imaging and recent efforts focused on specificity of contrast agents on specific organs such as liver, blood, lymph nodes, atherosclerotic plaque, and tumor. Furthermore, we will discuss the combination of theranostic such as contrast agent and drug, contrast agent and thermal therapy, contrast agent and photodynamic therapy, and neutron capture therapy, which can provide for cancer diagnosis and therapeutics.ConclusionThese applications of magnetic resonance contrast agents demonstrate the usefulness of theranostic agents for diagnosis and treatment.

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Theranostic liposomes as a bimodal carrier for magnetic resonance imaging contrast agent and photosensitizer

Cited by 39 publications

References 54 publications

Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles

Advantages and Limitations of Current Techniques for Analyzing the Biodistribution of Nanoparticles

The Positive Influence of Therapeutic Agent on Relaxivities of Gadolinium-Loaded Liposomal Theranostics

Theranostics and contrast agents for magnetic resonance imaging

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