Theranostics and contrast agents for magnetic resonance imaging

Jeong, Yohan; Hwang, Hee Sook; Na, Kun

doi:10.1186/s40824-018-0130-1

Cited by 56 publications

(33 citation statements)

References 126 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results suggest that IronQ is the most outstanding theranostic agent in applications of cell-based therapy. Recently, theranostic agents, including MRI contrast agents, have been developed for the purpose of diagnosis and therapy at the same time [37]. For example, a tumor specific magnetic nanoparticle-loaded doxorubicin agent has been developed by various research groups in the imaging and treatment of cancer [38,39].…”

Section: Discussionmentioning

confidence: 99%

Iron–Quercetin Complex Preconditioning of Human Peripheral Blood Mononuclear Cells Accelerates Angiogenic and Fibroblast Migration: Implications for Wound Healing

Kantapan

Anukul

Leetrakool

et al. 2021

IJMS

View full text Add to dashboard Cite

Cell-based therapy is a highly promising treatment paradigm in ischemic disease due to its ability to repair tissue when implanted into a damaged site. These therapeutic effects involve a strong paracrine component resulting from the high levels of bioactive molecules secreted in response to the local microenvironment. Therefore, the secreted therapeutic can be modulated by preconditioning the cells during in vitro culturing. Herein, we investigated the potential use of magnetic resonance imaging (MRI) probes, the “iron–quercetin complex” or IronQ, for preconditioning peripheral blood mononuclear cells (PBMCs) to expand proangiogenic cells and enhance their secreted therapeutic factors. PBMCs obtained from healthy donor blood were cultured in the presence of the iron–quercetin complex. Differentiated preconditioning PBMCs were characterized by immunostaining. An enzyme-linked immunosorbent assay was carried out to describe the secreted cytokines. In vitro migration and tubular formation using human umbilical vein endothelial cells (HUVECs) were completed to investigate the proangiogenic efficacy. IronQ significantly increased mononuclear progenitor cell proliferation and differentiation into spindle-shape-like cells, expressing both hematopoietic and stromal cell markers. The expansion increased the number of colony-forming units (CFU-Hill). The conditioned medium obtained from IronQ-treated PBMCs contained high levels of interleukin 8 (IL-8), IL-10, urokinase-type-plasminogen-activator (uPA), matrix metalloproteinases-9 (MMP-9), and tumor necrosis factor-alpha (TNF-α), as well as augmented migration and capillary network formation of HUVECs and fibroblast cells, in vitro. Our study demonstrated that the IronQ-preconditioning PBMC protocol could enhance the angiogenic and reparative potential of non-mobilized PBMCs. This protocol might be used as an adjunctive strategy to improve the efficacy of cell therapy when using PBMCs for ischemic diseases and chronic wounds. However, in vivo assessment is required for further validation.

show abstract

Section: Discussionmentioning

confidence: 99%

Iron–Quercetin Complex Preconditioning of Human Peripheral Blood Mononuclear Cells Accelerates Angiogenic and Fibroblast Migration: Implications for Wound Healing

Kantapan

Anukul

Leetrakool

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Among the various nanomaterials that can be found in the literature with different shapes and compositions, magnetic nanostructures (MNS), and in particular, nanodiscs and nanowires, are promising alternatives to SPIONs due to their larger magnetic moments that are not restrained by the superparamagnetic regime [ 7 ]. Also, MNS are a promising system for theragnostics, since they can be used as contrast agents and, at the same time, generate localized heating inside the body with the use of an external alternating current (AC) magnetic field, or be used for controlled drug delivery, photodynamic therapy and neutron capture therapy [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanomaterials as Contrast Agents for MRI

et al. 2020

View full text Add to dashboard Cite

Magnetic Resonance Imaging (MRI) is a powerful, noninvasive and nondestructive technique, capable of providing three-dimensional (3D) images of living organisms. The use of magnetic contrast agents has allowed clinical researchers and analysts to significantly increase the sensitivity and specificity of MRI, since these agents change the intrinsic properties of the tissues within a living organism, increasing the information present in the images. Advances in nanotechnology and materials science, as well as the research of new magnetic effects, have been the driving forces that are propelling forward the use of magnetic nanostructures as promising alternatives to commercial contrast agents used in MRI. This review discusses the principles associated with the use of contrast agents in MRI, as well as the most recent reports focused on nanostructured contrast agents. The potential applications of gadolinium- (Gd) and manganese- (Mn) based nanomaterials and iron oxide nanoparticles in this imaging technique are discussed as well, from their magnetic behavior to the commonly used materials and nanoarchitectures. Additionally, recent efforts to develop new types of contrast agents based on synthetic antiferromagnetic and high aspect ratio nanostructures are also addressed. Furthermore, the application of these materials in theragnosis, either as contrast agents and controlled drug release systems, contrast agents and thermal therapy materials or contrast agents and radiosensitizers, is also presented.

show abstract

“…Among several nanomaterials that can be found in the literature with different shapes and compositions, magnetic nanostructures (MNS), in particularly nanodiscs and nanowires, are promising alternatives to SPIONs due to their larger magnetic moments that are not restricted by the superparamagnetic limit [7]. Also, MNS are a promising system for theragnostic since they can be used as contrast agents and at the same time generate a localized heating inside the body with the use of an external alternating current (AC) magnetic field or be used for controlled drug delivery, photodynamic therapy, and neutron capture therapy [8] and [9]. This review is focused on the recent advances in magnetic nanoparticles as contrast enhancing agents in MRI.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanomaterials as Contrast Agents for MRI

Caspani¹,

Magalhães²,

Araújo³

et al. 2020

Preprint

View full text Add to dashboard Cite

Magnetic Resonance Imaging (MRI) is a powerful, non-invasive and nondestructive tool, capable of providing three-dimensional (3D) images of living organisms. The use of magnetic contrast agents has allowed clinical researchers and analysts to enormously increase the sensitivity and specificity of MRI since these substances change the intrinsic properties of the tissues within a living body, increasing the information present in the images. The advances in nanotechnology and materials science as well as the research of new magnetic effects have been the driving forces that propel the use of magnetic nanostructures as promising alternatives to the commercial contrast agents used in MRI. This review discusses the principles associated with the use of contrast agents in MRI as well as the most recent reports focused on nanostructured contrast agents. The potential applications of gadolinium (Gd) and manganese Mn-based nanomaterials and iron oxide nanoparticles in this imaging technique are discussed as well, from their magnetic behavior to the mainly used materials and nanoarchitectures. Then, it is also addressed the recent efforts made to develop new types of contrast agents based on synthetic antiferromagnetic and high-aspect ratio nanostructures. Furthermore, the application of these materials in theragnosis, either as contrast agents and controlled drug release, contrast agents and thermal therapy or contrast agents and radiosensitizers, is also presented.

show abstract

Theranostics and contrast agents for magnetic resonance imaging

Cited by 56 publications

References 126 publications

Iron–Quercetin Complex Preconditioning of Human Peripheral Blood Mononuclear Cells Accelerates Angiogenic and Fibroblast Migration: Implications for Wound Healing

Iron–Quercetin Complex Preconditioning of Human Peripheral Blood Mononuclear Cells Accelerates Angiogenic and Fibroblast Migration: Implications for Wound Healing

Magnetic Nanomaterials as Contrast Agents for MRI

Magnetic Nanomaterials as Contrast Agents for MRI

Contact Info

Product

Resources

About