CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis

Junior, Geraldo Magela de Faria; Ayo, Christiane Maria; Oliveira, Amanda Priscila de; Lopes, Alessandro Garcia; Frederico, Fábio Batista; Silveira-Carvalho, Aparecida Perpétuo; Previato, Mariana; Barbosa, Amanda Pires; Murata, Fernando Henrique Antunes; Almeida, Gildásio Castello de; Siqueira, Rubens Camargo; Mattos, Luiz Carlos de; Mattos, Cinara Cássia Brandão de

doi:10.1016/j.actatropica.2017.12.012

Cited by 14 publications

(7 citation statements)

References 41 publications

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“…A protective effect of CCR5Δ32 allele variation on some conditions such as childhood asthma [64], type 2 diabetes (non-insulin-dependent diabetes mellitus) [65], Hepatitis B Virus (HBV) [66], liver in ammation in HCV infection [67, 68], osteomyelitis of Staphylococcus aureus infection [69] and Toxoplasmosis [70,71] has been reported. On the other hand, this polymorphism has been considered a risk factor for multiple sclerosis (MS) [72], symptomatic West Nile virus (WNV) infection [73], the severity of In uenza virus [74] severe form of coronavirus disease-2019 (COVID-19) [24], Streptococcus pneumoniae infection [75], and Tuberculosis [76].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of CCR5Δ32 genetic variant in the Turkmen population of Golestan province, northeast of Iran

Norasi

Rastegar

Hosseini

et al. 2023

Preprint

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The 32 bp deletion in the chemokine receptor (C-C motif) 5 gene (CCR5Δ32) is a natural loss of function polymorphism that prevents the protein from locating on the cell surface. This genetic variation acts as a double edge sword in the pathogenesis/defense mechanism of different health conditions, such as viral infections, autoimmune diseases, and cancers. Here, we evaluated the prevalence of CCR5Δ32 polymorphism in the Turkmen population of Golestan province, northeast of Iran. Blood samples were collected from 400 randomly selected Turkmen populations (199 women and 201 men), and genomic DNA was extracted. Characterization of CCR5Δ32 genotypes was performed by PCR using primers flanking the 32-nucleotide deletion in the CCR5 gene. The amplified DNA fragments were visualized on 2% agarose gel electrophoresis with cyber green staining under UV light. All individuals were of Turkmen ethnicity and lived in the Golestan province northeast of Iran. The mean age of all participants was 35.46 years, with a 20–45 years range. All the studied subjects were healthy without severe conditions such as autoimmune disease and viral infections. All individuals had no history of HIV infection. The PCR product visualization showed that all the samples were at the 330 bp size, suggesting the absence of the CCR5Δ32 allele in the study population. The presence of the CCR5Δ32 allele among Turkmens may be attributed to the admixture with European descent people. We conclude that the CCR5Δ32 polymorphism may be absent in the Iranian Turkmen population and further studies with large populations are needed.

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Section: Discussionmentioning

confidence: 99%

Prevalence of CCR5Δ32 genetic variant in the Turkmen population of Golestan province, northeast of Iran

Norasi

Rastegar

Hosseini

et al. 2023

Preprint

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“…Human genetic traits, especially variants in HLA, TLR and cytokine genes, have a fundamental involvement in the development of ocular toxoplasmosis (Fernández, Jaimes, Ortiz, & Ramírez, 2016). Polymorphisms of the CCR5 gene could impact ocular toxoplasmosis (De Faria Junior et al, 2018). Also, there is a body of evidence supporting an involvement of the CCR5∆32 variant in toxoplasmosis.…”

Section: Ccr5 and Ccr5δ32 In Parasitic Infectionsmentioning

confidence: 99%

“…In a brief description, Vallochi et al (2008) reported no association between the CCR5∆32 variant and ocular toxoplasmosis in Brazilian individuals. Subsequently, De Faria Junior et al (2018) investigated the polymorphism in patients with ocular toxoplasmosis and healthy controls from Brazil. The study found no statistically significant differences regarding CCR5∆32 allelic and genotypic frequencies between cases and controls, considering the polymorphism as an individual factor in the analysis.…”

Section: Ccr5 and Ccr5δ32 In Parasitic Infectionsmentioning

confidence: 99%

“…The study found no statistically significant differences regarding CCR5∆32 allelic and genotypic frequencies between cases and controls, considering the polymorphism as an individual factor in the analysis. However, individuals with CCR5 wild‐type genotype (normal CCR5 expression) plus AA or AG genotypes from CCR5‐59029 A/G variant (rs1799987) showed a higher risk of ocular toxoplasmosis development (De Faria Junior et al, 2018).…”

Section: Ccr5 and Ccr5δ32 In Parasitic Infectionsmentioning

confidence: 99%

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CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box

Ellwanger

Kaminski

Rodrigues

et al. 2020

Int J Immunogenetics

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The CCR5 molecule was reported in 1996 as the main HIV‐1 co‐receptor. In that same year, the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 infection. These findings led to extensive research regarding the CCR5, culminating in critical scientific advances, such as the development of CCR5 inhibitors for the treatment of HIV infection. Recently, the research landscape surrounding CCR5 has begun to change. Different research groups have realized that, since CCR5 has such important effects in the chemokine system, it could also affect other different physiological systems. Therefore, the effect of reduced CCR5 expression due to the presence of the CCR5Δ32 variant began to be further studied. Several studies have investigated the role of CCR5 and the impacts of CCR5Δ32 on autoimmune and inflammatory diseases, various types of cancer, and viral diseases. However, the role of CCR5 in diseases caused by bacteria and parasites is still poorly understood. Therefore, the aim of this article is to review the role of CCR5 and the effects of CCR5Δ32 on bacterial (brucellosis, osteomyelitis, pneumonia, tuberculosis and infection by Chlamydia trachomatis) and parasitic infections (toxoplasmosis, leishmaniasis, Chagas disease and schistosomiasis). Basic information about each of these infections was also addressed. The neglected role of CCR5 in fungal disease and emerging studies regarding the action of CCR5 on regulatory T cells are briefly covered in this review. Considering the “renaissance of CCR5 research,” this article is useful for updating researchers who develop studies involving CCR5 and CCR5Δ32 in different infectious diseases.

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“…A set of human host genetic factors related to the acquisition risk of infection by T. gondii in diseased and healthy individuals is available in the literature. Polymorphisms of cell receptors such as Toll-Like Receptors (TLR-2: 2258G>A; TLR-4: 896A>G and 1196C>T, TLR-9: 2848G>A) (Wujcicka et al, 2017) and coreceptors (CCR5: 59029 AA or AG genotypes) (De Faria Junior et al, 2018) were associated with increased susceptibility. Genes and alleles controlling the immune response such as MICA and their HLA ligands (MICA-HLA: MICA*002~HLA-B*35), and KIR (KIR: KIR3DS1-Bw4-80Ile; KIR2DS1 + /C2 ++ KIR3DS1 + /Bw4-80Ile + ) increase the risk of infection (Ayo et al, 2015;Ayo et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii

Mattos

Ferreira

Oliveira

et al. 2021

Front. Cell. Infect. Microbiol.

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The glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems synthesize part of the carbohydrate antigens in hematopoietic and non-hematopoietic tissues. The combined action of these glycosyltransferases strongly influences cell, tissue, mucosa, and exocrine secretion carbohydrate phenotypes, including those serving as habitat for mutualistic and pathogenic microorganisms. A set of reports investigated associations between Toxoplasma gondii infection and the ABO histo-blood group system, but the results are contradictory. As T. gondii uses the gastrointestinal tract as a route for infection, and in this organ, the expression of ABO, Lewis, and Secretor histo-blood group carbohydrates occurs, it is reasonable to suppose some biological relationship between them. This text reviewed association studies published in recent decades focusing on the potential contribution of the ABO, Lewis, and Secretor histo-blood group carbohydrates and infection by T. gondii.

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CCR5 chemokine receptor gene polymorphisms in ocular toxoplasmosis

Cited by 14 publications

References 41 publications

Prevalence of CCR5Δ32 genetic variant in the Turkmen population of Golestan province, northeast of Iran

Prevalence of CCR5Δ32 genetic variant in the Turkmen population of Golestan province, northeast of Iran

CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box

The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii

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