The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii

Mattos, Luiz Carlos de; Ferreira, Ana Iara Costa; Oliveira, Karina Younan de; Nakashima, Fabiana; Mattos, Cinara Cássia Brandão de

doi:10.3389/fcimb.2021.671958

Cited by 3 publications

(3 citation statements)

References 105 publications

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“…Infection with T. gondii occurs through the gastrointestinal tract where the expression of the ABO blood groups glycoconjugates also occurs and thus ABO blood groups may influence the human susceptibility of this infection [ 21 ]. The combined action of glycosyltransferases encoded by genes from the human ABO, Lewis, and Secretor histo-blood group systems strongly influences cell, tissue, mucosa, and exocrine secretion carbohydrate phenotypes, including those serving as habitat for mutualistic and pathogenic microorganism [ 23 ]. Therefore, we determined the association between T. gondii infection and ABO and Rh blood groups in a large sample of people in Durango, Mexico.…”

Section: Discussionmentioning

confidence: 99%

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Pérez-Álamos,

Aguilar-Durán,

Estrada Martínez

et al. 2024

EuJMI

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We aimed to determine the association between the seropositivity to Toxoplasma gondii and the ABO and Rh blood groups in 2,053 people. ABO and Rhesus blood groups and anti-T. gondii IgG and IgM antibodies were determined using commercially available assays. Of the 2,053 people studied, 171 (8.3%) were positive for anti-T. gondii IgG antibodies. Sixty-five (38.0%) and 36 (21.1%) of these 171 individuals had high anti-T. gondii IgG antibody levels (≥150 IU mL−1) and anti-T. gondii IgM antibodies, respectively. We found the following prevalences of T. gondii infection among the ABO groups: 8.5% in group A, 4.3% in group B, 4.7% in group AB, and 8.9% in group O (P = 0.19). The prevalences of T. gondii infection among Rh groups were: 8.4% in the Rh-positive group and 7.1% in the Rh-negative group (P = 0.58). Logistic regression analysis showed that the frequencies of ABO and Rh blood groups were similar (P > 0.05) among people with positive and negative serology for anti-T. gondii IgG antibodies, with high (≥150 IU mL−1) and lower (<150 IU mL−1) levels of anti-T. gondii IgG antibodies, and with positive and negative serology for anti-T. gondii IgM antibodies. Results does not support an association between T. gondii infection and ABO and Rh blood groups.

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Section: Discussionmentioning

confidence: 99%

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Pérez-Álamos,

Aguilar-Durán,

Estrada Martínez

et al. 2024

EuJMI

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“…The sporulation time is between 2 and 21 days, and oocysts persist in the environment for a year or more, depending on the environmental conditions. 9 Previous study suggested that Toxoplasma antibodies are more prevalent in women who have cats or breeding cats at home than in women who do not breed and have cats. 6 To prevent and control cats from becoming infected, domestic cats must be fed sufficiently cooked meat and kept indoors to minimize scavenging or hunting.…”

Section: Discussionmentioning

confidence: 99%

“…8 Most cases of Toxoplasma gondii infection in humans are probably gained by sporulated oocyst ingestion in the soil or contaminated and polluted vegetables and fruits. 2 , 6 , 9 Nowadays, Toxoplasma gondii infection is recognized and considered to be a water-borne zoonotic disease, 10 this mode of transmission occurs where water treatment is ineffective. 10 , 11 Additionally, there is also an appreciation that sea mammals are becoming infected by waters from contaminated land areas and untreated urban sewage effluents.…”

Section: Introductionmentioning

confidence: 99%

Toxoplasma gondii Infection and ABO Blood Group Association Among Pregnant Sudanese Women: A Case Study

Magboul,

Elamin,

Tamomh

et al. 2023

IJWH

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Purpose ABO blood group glycol-conjugate expression may influence human susceptibility to infection caused by Toxoplasma gondii . This study aimed to assess the relationship between blood group phenotypes as risk factors for toxoplasmosis and to correlate the prevalence of the disease with other risk factors. Materials and Methods A total of two-hundred serum samples were collected from pregnant women referred for routine rotary examination in Rabak Teaching Hospital, White Nile State, Sudan, and examined for the parasite Toxoplasma gondii using the latex agglutination test. Results The overall prevalence of toxoplasmosis in pregnant women (IgG positivity for T. gondii in the absence of IgM) was 41% (82/200). A higher prevalence of the infection was detected in women with blood group type AB 5 (55.6%) among the females in the AB blood group and the lowest in those with blood group type B 11 (35.5%). Those with a history of direct contact with cats reported the possibility of eating undercooked meat and soil-related potential risk factors (working in a garden with bare hands, eating unwashed vegetables and fresh fruits, poor handling of food) recorded 70 (82.4%), 59 (65.6%), 58 (77.3%), 73 (55.7%) and 70 (73.7%) of positive cases, respectively. Statistical analysis revealed a significant difference between Toxoplasma gondii infection and these risk factors. Conclusion The study concluded that the ABO blood group system was not related to the absence or presence of anti- T. gondii antibodies in pregnant women in the study area. Contact with cat feces, raw meat consumption, and farming were identified as possible important risk factors for T. gondii infection within the study area.

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Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype

Kim

Yuan

Ámundadóttir

et al. 2023

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: In western populations, Pancreatic Ductal Adenocarcinoma (PDAC) risk has been found to be greater among individuals with non-O blood types than those with O blood type. However, the association has not been fully evaluated with respect to FUT2 (determining secretor status) and FUT3 (determining Lewis antigens) status, two biologically important genes in the expression of ABO blood groups with PDAC. Methods: We examined interactions in data from 8,027 cases and 11,362 controls in large pancreatic cancer consortia (PanScan I-III and PanC4) by utilizing genetic variants to predict ABO blood groups (rs505922 and rs8176746), secretor status (rs601338), and Lewis antigens (rs812936, rs28362459, and rs3894326). Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of the risk of PDAC adjusted for age and sex. We examined multiplicative interactions of ABO with secretor status and Lewis group by considering each product term between ABO and secretor and between ABO and Lewis group individually. Results: We found that the increased risk associated with non-O blood groups was somewhat stronger among secretors than non-secretors (ORs 1.28 [95% CI: 1.15-1.42] and 1.17 [95% CI: 1.03-1.32] respectively; interaction p-value = 0.002). We did not find any interactions between ABO and Lewis antigens. Conclusions: Our large consortia data provide evidence of effect modification in the association between non-O blood type and pancreatic cancer risk by secretor status. Impact: Our results indicate that the association between ABO blood type and PDAC risk may vary by secretor status, but not by Lewis antigens.

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The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection by Toxoplasma gondii

Cited by 3 publications

References 105 publications

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Association between ABO and Rh blood groups and Toxoplasma gondii infection: A cross sectional study

Toxoplasma gondii Infection and ABO Blood Group Association Among Pregnant Sudanese Women: A Case Study

Relationship between ABO Blood Group Alleles and Pancreatic Cancer Is Modulated by Secretor (FUT2) Genotype, but Not Lewis Antigen (FUT3) Genotype

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