Clustering based on unsupervised binary trees to define subgroups of cancer patients according to symptom severity in cancer

Michel, Pierre; Hamidou, Zeinab; Baumstarck, Karine; Ghattas, Badih; Resseguier, Noémie; Chinot, Olivier; Salas, Sébastien; Boyer, Laurent; Auquier, Pascal

doi:10.1007/s11136-017-1760-9

Cited by 1 publication

(1 citation statement)

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“…Patient-generated data are a largely underused asset that can bring additional information to clinical practice by increasing inclusion from patients without access to clinical trials and by informing oncologists about health influences, including variables like physical activity, diet, and blood pressure-each of which is patient-reportable and often overlooked. 153,154 In an ideal scenario, results obtained from various sources (medical history, genomics, proteomics, metabolomics, clinical trial, patient input, etc) would be validated and combined to allow physicians to stratify patients using sensitive and specific screening algorithms.…”

Section: Knowledge Gap and Challengesmentioning

confidence: 99%

Blueprint for cancer research: Critical gaps and opportunities

Elmore

Greer

Daniels

et al. 2020

CA A Cancer J Clinicians

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We are experiencing a revolution in cancer. Advances in screening, targeted and immune therapies, big data, computational methodologies, and significant new knowledge of cancer biology are transforming the ways in which we prevent, detect, diagnose, treat, and survive cancer. These advances are enabling durable progress in the goal to achieve personalized cancer care. Despite these gains, more work is needed to develop better tools and strategies to limit cancer as a major health concern. One persistent gap is the inconsistent coordination among researchers and caregivers to implement evidence‐based programs that rely on a fuller understanding of the molecular, cellular, and systems biology mechanisms underpinning different types of cancer. Here, the authors integrate conversations with over 90 leading cancer experts to highlight current challenges, encourage a robust and diverse national research portfolio, and capture timely opportunities to advance evidence‐based approaches for all patients with cancer and for all communities.

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Section: Knowledge Gap and Challengesmentioning

confidence: 99%