Distribution of ARGs and MGEs among glacial soil, permafrost, and sediment using metagenomic analysis

Zhang, Shuhong; Yang, Guangli; Hou, Shugui; Zhang, Tingjun; Li, Zhiguo; Liang, Feng

doi:10.1016/j.envpol.2017.11.031

Cited by 77 publications

(24 citation statements)

References 60 publications

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“…A large number (177) of ARGs encoding mostly single or multi-drug efflux pumps conferring resistance to aminoglycosides, chloramphenicol and β-lactams were reported in pristine Antarctic soils (Van Goethem et al, 2018). A low number and diversity of ARGs was detected in glacial soil and permafrost as compared to environments highly impacted by human activities in a study by Zhang et al (2018). It has been proposed that ARGs in pristine environments most likely represent functional historical genes conferring resistance to natural antibiotics.…”

Section: Diversity Of Antimicrobial Resistance Genesmentioning

confidence: 95%

Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity

2019

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Antibiotics play a key role in the management of infectious diseases in humans, animals, livestock, and aquacultures all over the world. The release of increasing amount of antibiotics into waters and soils creates a potential threat to all microorganisms in these environments. This review addresses issues related to the fate and degradation of antibiotics in soils and the impact of antibiotics on the structural, genetic and functional diversity of microbial communities. Due to the emergence of bacterial resistance to antibiotics, which is considered a worldwide public health problem, the abundance and diversity of antibiotic resistance genes (ARGs) in soils are also discussed. When antibiotic residues enter the soil, the main processes determining their persistence are sorption to organic particles and degradation/transformation. The wide range of DT50 values for antibiotic residues in soils shows that the processes governing persistence depend on a number of different factors, e.g., physico-chemical properties of the residue, characteristics of the soil, and climatic factors (temperature, rainfall, and humidity). The results presented in this review show that antibiotics affect soil microorganisms by changing their enzyme activity and ability to metabolize different carbon sources, as well as by altering the overall microbial biomass and the relative abundance of different groups (i.e., Gram-negative bacteria, Gram-positive bacteria, and fungi) in microbial communities. Studies using methods based on analyses of nucleic acids prove that antibiotics alter the biodiversity of microbial communities and the presence of many types of ARGs in soil are affected by agricultural and human activities. It is worth emphasizing that studies on ARGs in soil have resulted in the discovery of new genes and enzymes responsible for bacterial resistance to antibiotics. However, many ambiguous results indicate that precise estimation of the impact of antibiotics on the activity and diversity of soil microbial communities is a great challenge.

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Section: Diversity Of Antimicrobial Resistance Genesmentioning

confidence: 95%

Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity

2019

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“…Antibiotic resistance to currently used and frequently overused antibiotics is a growing problem in the pharmacotherapy of bacterial infections. Therefore, it is very important to search for new substances, including those of natural origin, that can be used to combat pathogens [20,21]. Bacterial and fungal resistance to antibiotics and disinfectants is related to their ability of biofilm production that prevents the penetration of the antibacterial agent into the site of infection.…”

Section: Activity Against Microbiological Biofilmsmentioning

confidence: 99%

Thymol and Thyme Essential Oil—New Insights into Selected Therapeutic Applications

et al. 2020

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Thymol (2-isopropyl-5-methylphenol) belongs to the phenolic monoterpenes and mostly occurs in thyme species. It is one of the main compounds of thyme essential oil. Both thymol and thyme essential oil have long been used in traditional medicine as expectorant, anti-inflammatory, antiviral, antibacterial, and antiseptic agents, mainly in the treatment of the upper respiratory system. The current search for new directions of biological or therapeutic activities of natural plant substances with known structures includes thyme essential oil and thymol. Novel studies have demonstrated their antibiofilm, antifungal, antileishmanial, antiviral, and anticancer properties. Also, their new therapeutic formulations, such as nanocapsules containing these constituents, can be beneficial in medicinal practice and create opportunities for their extensive use. Extensive application of thymol and thyme essential oil in the healthcare sector is very promising but requires further research and analysis.

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“…INTEGRALL [101,102] focuses on integron sequences and gene cassettes, while ISfinder [103] is used for insertion sequence comparisons. The National Center for Biotechnology Information (NCBI) can be used for plasmid gene alignments [104]. Antibiotic Resistance Genes Database (ARDB), maintained by the University of Maryland, was commonly used but is no longer being maintained and has been merged with the CARD database (http://card.mcmaster.ca/home), maintained by McMaster University, Canada.…”

Section: Metagenomic Analysismentioning

confidence: 99%

Research and Technological Advances Regarding the Study of the Spread of Antimicrobial Resistance Genes and Antimicrobial-Resistant Bacteria Related to Animal Husbandry

Liu

Zhang

et al. 2019

IJERPH

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The extensive use of antimicrobials in animal farms poses serious safety hazards to both the environment and public health, and this trend is likely to continue. Antimicrobial resistance genes (ARGs) are a class of emerging pollutants that are difficult to remove once introduced. Understanding the environmental transfer of antimicrobial-resistant bacteria (ARB) and ARGs is pivotal for creating control measures. In this review, we summarize the research progress on the spread and detection of ARB and ARG pollution related to animal husbandry. Molecular methods such as high-throughput sequencing have greatly enriched the information about ARB communities. However, it remains challenging to delineate mechanisms regarding ARG induction, transmission, and tempo-spatial changes in the whole process, from animal husbandry to multiple ecosystems. As a result, future research should be more focused on the mechanisms of ARG induction, transmission, and control. We also expect that future research will rely more heavily on metagenomic -analysis, metatranscriptomic sequencing, and multi-omics technologies

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Distribution of ARGs and MGEs among glacial soil, permafrost, and sediment using metagenomic analysis

Cited by 77 publications

References 60 publications

Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity

Antibiotics in the Soil Environment—Degradation and Their Impact on Microbial Activity and Diversity

Thymol and Thyme Essential Oil—New Insights into Selected Therapeutic Applications

Research and Technological Advances Regarding the Study of the Spread of Antimicrobial Resistance Genes and Antimicrobial-Resistant Bacteria Related to Animal Husbandry

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