Effects of Δ(9)-tetrahydrocannabinol (THC) on human amniotic epithelial cell proliferation and migration.

Yao, Julei; He, Qizhi; Liu, M.; Chang, Xinwen; Wu, Janice; Duan, Tao; Wang, K.

doi:10.1016/j.tox.2017.11.016

Cited by 15 publications

(10 citation statements)

References 21 publications

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“…Fourthly, cannabinoids also had an impact on cell adhesion and migration in the human reproductive system. These included reducing sperm motility via their receptors in spermatozoa (Agirregoitia et al, ) and inhibition of human amniotic epithelial cell migration to alter the amnion development during gestation which may partially result in adverse pregnancy outcomes (Yao et al, ). In addition, cannabinoids were also reported in regulating tissue morphogenesis and development by stem cells, neurons etc.…”

Section: Discussionmentioning

confidence: 99%

Activation of cannabinoid receptors promote periodontal cell adhesion and migration

Liu

Alhabeil

et al. 2019

J Clinic Periodontology

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Objective Medical and recreational cannabis use is increasing significantly, but its impacts on oral health remain unclear. The aim of this study is to investigate the effects of tetrahydrocannabinol (THC), the major active component in cannabis, on periodontal fibroblast cell adhesion and migration to explore its role in periodontal regeneration and wound healing. Material and Methods The different distribution of cannabinoid receptors 1 (CB1) and 2 (CB2) was characterized in the mouse periodontium. Human periodontal fibroblast cell (HPLF) adhesion and migration was analysed by in vitro wound healing assay with and without THC. The focal adhesion kinase (FAK) signalling pathway was investigated to uncover the underlying cellular mechanism. The receptor dependency of cannabinoid effects was examined by using selective antagonists to block THC. Results Both CB1 and CB2 were expressed in periodontal tissues but with different expression patterns. Tetrahydrocannabinol promoted periodontal cell wound healing by inducing HPLF cell adhesion and migration. This was mediated by focal adhesion kinase (FAK) activation and its modulation of MAPK activities. The effect of cannabinoids on periodontal fibroblast cell adhesion and migration was mainly dependent on the CB2. Conclusion These results suggested that cannabinoids may contribute to developing new therapeutics for periodontal regeneration and wound healing.

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Section: Discussionmentioning

confidence: 99%

Activation of cannabinoid receptors promote periodontal cell adhesion and migration

Liu

Alhabeil

et al. 2019

J Clinic Periodontology

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“…Alongside increasingly permissive sociocultural attitudes and laws surrounding cannabis, 1 past month use among pregnant women increased by 106% from 2002(3.4%) to 2017(7.0%) in the United States. 2 Tetrahydrocannabinol (THC), the psychoactive component of cannabis, crosses the placenta 3 and interfaces with the endocannabinoid system, which critically influences neural development. [3][4][5] Thus, it is plausible that cannabis use during pregnancy may impact offspring.…”

Section: Introductionmentioning

confidence: 99%

“…2 Tetrahydrocannabinol (THC), the psychoactive component of cannabis, crosses the placenta 3 and interfaces with the endocannabinoid system, which critically influences neural development. 3-5 Thus, it is plausible that cannabis use during pregnancy may impact offspring. Indeed, the alarming increase of cannabis use among pregnant mothers, 2,6-8 and evidence linking prenatal exposure to adverse outcomes in children 9-13 prompted the Surgeon General of the United States to release an advisory against cannabis use during pregnancy and breastfeeding on August 29 th 2019.…”

Section: Introductionmentioning

confidence: 99%

Prenatal cannabis exposure and childhood outcomes: Results from the ABCD study

Paul¹,

Hatoum²,

Fine³

et al. 2019

Preprint

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Importance: In light of increasing cannabis use among pregnant women, the Surgeon General of the United States issued an advisory against the use of marijuana during pregnancy on August 29th, 2019. Objective: To determine whether cannabis use during pregnancy is associated with adverse outcomes among offspring. Design: Cross-sectional analysis of the baseline session of the ongoing longitudinal Adolescent Brain and Cognitive Development (ABCD) study. Setting: Data were collected from 22 sites across the United States between 2016 and 2018. Participants: Children ages 9-11 (n=11,489) and their parent or caregiver. Exposure: Prenatal marijuana exposure prior to and following maternal knowledge of pregnancy. Main Outcomes and Measures: Child psychopathology symptomatology (i.e., psychotic-like experiences and internalizing, externalizing, attention, thought, and social problems), cognition, sleep, birth weight, gestational age at birth, body mass index (BMI), and brain structure (i.e., total intracranial volume, white matter volume, gray matter volume). Covariates included familial (e.g., income, familial psychopathology), pregnancy (e.g., prenatal vitamin use, whether the pregnancy was planned), and child (e.g., birth weight, substance use) variables. Results: Among 11,489 children (age 9.9±0.6 years; 47.78% female), 655 (5.70%) were prenatally exposed to cannabis in total. Marijuana use prior to (n=648; 5.64%) and following (n=242; 2.11%) maternal knowledge of pregnancy were associated with increased offspring psychopathology characteristics (i.e., psychotic-like experiences and internalizing, externalizing, attention, thought, social, and sleep problems) and BMI as well as reduced cognition, birth weight, and brain structure (i.e., total white and gray mater volumes; all psfdr<.007), but not gestational age at birth. Exposure following maternal knowledge of pregnancy remained significantly associated with psychopathology, cognition, and birth weight outcomes when including potentially confounding variables (all ps<0.046). All associations with exposure prior to maternal knowledge of pregnancy were nonsignificant when considering potentially confounding variables (all ps>0.06). Conclusions and Relevance: Prenatal cannabis exposure, and its correlated factors, may increase risk for psychopathology and reduced cognition during middle childhood as well as reduced birthweight. Consistent with recent recommendations by the Surgeon General, marijuana use during pregnancy should be discouraged.

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“…This discovery of the relevance of CB1‐mediated signaling led to study of the mechanism by Yao et al, who examined the presence of both CB1 and CB2 receptors in the human placenta and identified that the treatment of human amniotic placental cells with Δ9‐THC decreased cell migration through the regulation of MMP9 and MMP2 metalloproteinases. 66 CB1 signaling likely plays a role in cell migration in both physiologic and pathological contexts including malignancy. Numerous papers have examined the effects of CB1 activation on cancer cell migration and invasion and found conflicting results.…”

Section: Cannabinoid Receptor Activation and Cancer Cell Invasionmentioning

confidence: 99%

“…The results showed migratory responses occurring at least in part through CB1-mediated intracellular signaling pathways, and this effect could be abrogated using a selective CB1 antagonist SR141716A. This discovery of the relevance of CB1-mediated signaling led to study of the mechanism by Yao et al, who examined the presence of both CB1 and CB2 receptors in the human placenta and identified that the treatment of human amniotic placental cells with Δ9-THC decreased cell migration through the regulation of MMP9 and MMP2 metalloproteinases 66. CB1 signaling likely plays a role in cell migration in both physiologic and pathological contexts including malignancy.…”

mentioning

confidence: 99%

Cannabinoids, their cellular receptors, and effects on the invasive phenotype of carcinoma and metastasis

Glogauer

Blay

2021

Cancer Reports

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Background: The morbidity and mortality of cancer are significantly impacted by the invasive and metastatic potential of particular subgroups of malignant cells within a tumor. The particular pre-metastatic properties of cancerous cells are thus a critical target for novel therapeutics in the oncology field. Cannabinoid molecules have been investigated in recent years in the context of invasion and metastasis of various malignancies, with varying effects reported in the literature.Recent Findings: There was substantial variability in the findings reported by the literature of the effects of cannabinoid molecules on cancer cell invasion and metastasis. These effects varied depending on which ligand and which of the CB1, CB2, or GPR55 receptors were investigated. These findings suggest a role for the phenomenon of biased signaling in explaining the diversity of effects of cannabinoid molecules on cancer cell invasion. Conclusion:While substantially more investigation is required into the effects of cannabinoid molecules on cancer cell invasion and metastasis, we describe in this review the significant diversity in the responses of cancer cells to cannabinoid molecules in terms of their invasive and metastatic capacities.

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Effects of Δ(9)-tetrahydrocannabinol (THC) on human amniotic epithelial cell proliferation and migration.

Cited by 15 publications

References 21 publications

Activation of cannabinoid receptors promote periodontal cell adhesion and migration

Activation of cannabinoid receptors promote periodontal cell adhesion and migration

Prenatal cannabis exposure and childhood outcomes: Results from the ABCD study

Cannabinoids, their cellular receptors, and effects on the invasive phenotype of carcinoma and metastasis

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