A New Theranostic System Based on Endoglin Aptamer Conjugated Fluorescent Silica Nanoparticles

Tan, Juntao; Yang, Nuo; Zhong, Liping; Tan, Jie; Hu, Zixi; Zhao, Qing; Gong, Wenlin; Zhang, Zhenghua; Zheng, Rong; Lai, Zongqiang; Li, Yanmei; Zhou, Chaofan; Zhang, Guoqing; Zheng, Duo; Zhang, Ying; Wu, Shao Peng; Jiang, Xinglu; Zhong, Jian‐Hong; Huang, Yong; Zhou, Sufang; Zhao, Yongxiang

doi:10.7150/thno.19101

Cited by 32 publications

(19 citation statements)

References 46 publications

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“…Tan et al developed a novel theranostic system based on endoglin aptamer (YQ26)-modified fluorescent silica NPs (YQ26-FsiNPs) for tumor imaging, treatment, and monitoring. 44 Use of YQ26-FSiNPs resulted in high targeting efficiency and excellent therapeutic effects via aptamer YQ26-mediated binding. In vitro and in vivo studies showed that YQ26-FSiNPs was a promising agent for clinical tumor diagnosis and treatment.…”

Section: Aptamers For Biomedical Imagingmentioning

confidence: 99%

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Guan¹,

Zhang²

2020

IJN

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Aptamers are a class of targeting ligands that bind exclusively to biomarkers of interest. Aptamers have been identified as candidates for the construction of various smart systems for therapy, diagnosis, bioimaging, and drug delivery due to their high target affinity and specificity. Aptamers are accounted as chemical antibodies that can be readily linked to drugs, sensors, signal enhancers, or nanocarriers for functionalization. Use of aptamer-guided medications, especially nanomedicines, has resulted in encouraging outcomes compared to those use of aptamer-free counterparts. This article reviews recent advances in the use of aptamers as targeting ligands for various biomedical and pharmaceutical purposes. Special interests focus on aptamer-based theranostics, biosensing, bioimaging, drug potentiation, and targeted drug delivery.

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Section: Aptamers For Biomedical Imagingmentioning

confidence: 99%

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Guan¹,

Zhang²

2020

IJN

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“…Additionally, laser irradiation at 808 nm of breast tumors in mice model treated with these DIR-loaded nanocarriers showed a significant tumor reduction by photothermal therapy (PTT) due to temperature increase in the zone. Fluorescent MSN decorated with the aptamer YQ26 have been employed to visualize tumoral blood vessels in mice models [ 41 ]. Aptamers are single-stranded DNA or RNA sequences that adopt 3D conformations able to selectively bind to certain molecules as proteins, peptides, sugars, ions, or phospholipids.…”

Section: Optical Theranosticsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Baeza

Vallet‐Regí

2020

Pharmaceutics

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Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The enhanced permeation and retention effect for loaded nanocarriers in tumors allow substantial improvement of selectivity and safety of anticancer nanomedicines. Additionally, the possibility to design stimuli-responsive nanocarriers able to release their payload in response to specific stimuli provide an excellent control on the administered dosage. The aim of this review is not to present a comprehensive revision of the different theranostic mesoporous silica nanoparticles (MSN) which have been published in the recent years but just to describe a few selected examples to offer a panoramic view to the reader about the suitability and effectiveness of these nanocarriers in the oncology field.

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“…In addition to the above‐mentioned aptamer–nanomaterial systems, other types of aptamer‐based nanomaterials, such as liposome, silica nanomaterials, polymer nanomaterials, MOFs, dendrimers, micellar nanoparticles, gadolinium oxide nanoparticles, calcium carbonate nanostructure, polydopamine nanospheres, MoS 2 nanoplates, lipid‐based nanobubbles, dipeptide nanoparticles, aggregation‐induced emission organic dots, and MnO 2 nanosheet, have been engineered as promising candidates toward in vivo applications in diverse areas. Based on these studies, we summarize the representative reports focusing on aptamers integrated with other nanomaterials, as shown in Table 2 .…”

Section: Molecular Engineering Of Aptamer‐based Nanomaterials Toward mentioning

confidence: 99%

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

Zhang

Lan

2019

Adv Healthcare Materials

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equally exciting and perhaps more challenging field of application is toward their in vivo applications, including living animals and human bodies, in diverse areas, [2] such as sensing, drug delivery, medical imaging, and cancer therapy. However, most of these nanomaterials lack selectivity toward targets of interests. Therefore, to employ these nanomaterials for a wider range of in vivo applications, various molecular engineering approaches have been employed to obtained nanomaterials functionalized with biomolecules to enable selective targeting. [3][4][5] Among these biomolecules, functional nucleic acids, or FNAs, have shown the most promise.FNAs are DNA or RNA molecules that can interact with or bind to a specific analyte, resulting in a conformational change and/or a catalytic reaction. [6] As their names suggested, ribozymes and deoxyribozymes (called DNAzyme hereafter) can act as enzymes in the presence of cofactors to catalyze various reactions, including cleavage and ligation of RNA/DNA, and phosphorylation and peroxidation of DNA. On the other hand, riboswitches and DNA aptamers are antibody-like receptors that can bind target molecules with high affinity and selectivity. Furthermore, the binding abilities of riboswitches and aptamers can be combined with the enzymatic function of ribozymes or DNAzymes to form aptazymes so that the binding of targets can inhibit or enhance the catalytic activities. These nucleic acids, including DNAzymes, aptamers, and aptazymes, are collectively known as FNAs to emphasize their functions beyond the traditional genetic storage and transformations roles for DNA and RNA. Unlike DNA and RNA inside biological systems, FNAs are isolated via a combinatorial technique known as in vitro selection, or a process also known as systematic evolution of ligands by exponential enrichment (SELEX). The discovery of new functions of nucleic acids has not only resulted in major advances in the fields of molecular biology and biochemistry, but also revolutionized sensors designs for both in vitro and in vivo applications. [7,8] Over the past decade, numerous FNA-based nanomaterials have been developed. [9][10][11][12] Among these FNA-based nanosystems, the functions of FNAs can be categorized into two types: diagnostic function and therapeutic function. For the diagnostic function, the FNAs serve either as the biorecognition ligands for direct sensing and imaging of the Recent advances in nanotechnology and engineering have generated many nanomaterials with unique physical and chemical properties. Over the past decade, numerous nanomaterials are introduced into many research areas, such as sensors for environmental monitoring, food safety, point-ofcare diagnostics, and as transducers for solar energy transfer. Meanwhile, functional nucleic acids (FNAs), including nucleic acid enzymes, aptamers, and aptazymes, have attracted major attention from the biomedical community due to their unique target recognition and catalytic properties. Benefiting from the recent progress of molecular engine...

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A New Theranostic System Based on Endoglin Aptamer Conjugated Fluorescent Silica Nanoparticles

Cited by 32 publications

References 46 publications

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Molecular Engineering of Functional Nucleic Acid Nanomaterials toward In Vivo Applications

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