SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy

Zhang, Meng; Cui, Zhaowen; Song, Ruixue; Lv, Bin; Tang, Zhongmin; Meng, Xianfu; Chen, Xiaoyan; Zheng, Xiangpeng; Zhang, Jiawen; Yao, Zhenwei; Bu, Wenbo

doi:10.1016/j.biomaterials.2017.11.013

Cited by 80 publications

(48 citation statements)

References 26 publications

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“…Briefly, the oxygen-saturated solution containing BP or HA-BP (BP: 50 μg/mL) or methylene blue (MB) mixing with DPBF (20 μg/mL) were kept in the dark and irradiated with 635 nm laser (0.5 W/cm 2 ) or 808 nm laser (1.5 W/cm 2 ) for 3 min in an interval of 30 s. The ΔOD of DPBF oxidation at 410 nm was detected by UV–vis spectrophotometer. The Φ Δ values of BP and HA-BP were evaluated by the MB in DMF (Φ Δ = 0.52) as the standard [ 45 , 46 ].…”

Section: Methodsmentioning

confidence: 99%

A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy

Zhang¹,

Tang²,

Li³

et al. 2021

Bioactive Materials

149

116

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Photo-immunotherapy is a novel therapeutic approach against malignant tumors with minimal invasiveness. Herein, a targeting multifunctional black phosphorus (BP) nanoparticle, modified by PEGylated hyaluronic acid (HA), was designed for photothermal/photodynamic/photo-immunotherapy. In vitro and in vivo assays indicated that HA-BP nanoparticles possess excellent biocompatibility, stability, and sufficient therapeutic efficacy in the combined therapy of photothermal therapy (PTT) and photodynamic therapy (PDT) for cancer therapy. Moreover, the results of in vitro showed that HA-BP down-regulated the expression of CD206 (M2 macrophage marker) by 42.3% and up-regulated the ratio of CD86（M1 macrophage marker）by 59.6%, indicating that HA-BP nanoparticles have functions in remodeling tumor associated macrophages (TAMs) phenotype (from pro-tumor M2 TAMs to anti-tumor M1 macrophages). Fluorescence (FL) and photoacoustic (PA) multimodal imaging confirmed the selective accumulation of HA-BP in tumor site via both CD44 + mediated active targeting and passive EPR effect. In vitro and in vivo studies suggested that the combined therapy of PDT, PTT and immunotherapy using HA-BP could not only significantly inhibit original tumor but also induce immunogenic cell death (ICD) and release Damage-associated molecular patterns (DAMPs), which could induce maturation of dendritic cells (DCs) and activate effector cells that robustly evoke the antitumor immune responses for cancer treatment. This study expands the biomedical application of BP nanoparticles and displays the potential of modified BP as a multifunctional therapeutic platform for the future cancer therapy.

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Section: Methodsmentioning

confidence: 99%

A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy

Zhang¹,

Tang²,

Li³

et al. 2021

Bioactive Materials

149

116

View full text Add to dashboard Cite

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“…Later, based on the “partial matching” mechanism between UCNP emission and photosensitizers’ absorption, Bu's group developed a needle‐like SnWO 4 ‐nanocrystal, which was then covalently conjugated with UCNPs (NaYF 4 :Yb 3+ ,Tm 3+ @NaGdF 4 ) to form UCNP‐SnWO 4 nanohybrids. [ 87 ] SnWO 4 can serve as robust type I photosensitizers but intrinsically with short absorption wavelength (less than 600 nm). The UCNPs coated on the nanohybrids can receive photoenergy from 980‐nm laser and emit UV and visible light to activate SnWO 4 for type I ROS generation, realizing NIR‐triggered deep penetration PDT.…”

Section: Highly Efficient Type I Photosensitizers For Photodynamic Oncotherapymentioning

confidence: 99%

Type I Photosensitizers Revitalizing Photodynamic Oncotherapy

Chen

Wang

et al. 2021

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Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II PDT relying on 1O2 presents poor therapeutic efficacy for hypoxic tumors due to the oxygen‐dependent manner. Alternatively, emerging researches have demonstrated that type I PDT exhibits superiority over type II PDT in tumor treatment owing to its diminished oxygen‐dependence. In this review, state‐of‐the‐art studies concerning recent progress in type I photosensitizers are scrutinized, emphasizing the strategies to construct highly effective type I photosensitizers. As the foundation, basic principles of type I PDT are presented, and up‐to‐date type I photosensitizers are summarized and classified based on their attributes. Then, a literature review of representative type I photosensitizers (including nanomaterials and small molecules) is presented with impetus to delineate their novel designs, action mechanisms, as well as anticancer PDT applications. Finally, the remaining challenges and development directions of type I photosensitizers are outlined, highlighting key scientific issues toward clinical translations.

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“…The conventional nanomaterial‐modulated PDT and RT synergetic approaches need both the X‐ray and laser as excitation light source . For example, Liu et al employed the PEGylated nanoscale metal organic framework (NMOF) (NMOF‐PEG) to achieve PDT/RT combined therapy under both the X‐ray and 661 nm laser exposure .…”

Section: General Strategies Of Nanomaterial‐mediated Tumor Radiosensimentioning

confidence: 99%

“…For another example, Zhang et al designed and fabricated a SnWO 4 nanocrystal‐conjugated upconversion nanoparticle (UCNP‐SnWO 4 ). This nanoparticle could accomplish PDT/RT synergetic treatment under both X‐ray and 980 nm NIR light exposure . On the one hand, W and tin (Sn) (high Z atoms) with strong X‐ray attenuation capacity are excellent radiosensitizers.…”

Section: General Strategies Of Nanomaterial‐mediated Tumor Radiosensimentioning

confidence: 99%

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

et al. 2018

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Nano-radiosensitization has been a hot concept for the past ten years, and the nanomaterial-mediated tumor radiosensitization method is mainly focused on increasing intracellular radiation deposition by high atomic number (high Z) nanomaterials, particularly gold (Au)-mediated radiation enhancement. Recently, various new nanomaterial-mediated radiosensitive approaches have been successively reported, such as catalyzing reactive oxygen species (ROS) generation, consuming intracellular reduced glutathione (GSH), overcoming tumor hypoxia, and various synergistic radiotherapy ways. These strategies may open a new avenue for enhancing the radiotherapeutic effect and avoiding its side effects. Nevertheless, reviews systematically summarizing these newly emerging methods and their radiosensitive mechanisms are still rare. Therefore, the general strategies of nanomaterial-mediated tumor radiosensitization are comprehensively summarized, particularly aiming at introducing the emerging radiosensitive methods. The strategies are divided into three general parts. First, methods on account of the intrinsic radiosensitive properties of nanoradiosensitizers for radiosensitization are highlighted. Then, newly developed synergistic strategies based on multifunctional nanomaterials for enhancing radiotherapy efficacy are emphasized. Third, nanomaterial-mediated radioprotection approaches for increasing the radiotherapeutic ratio are discussed. Importantly, the clinical translation of nanomaterial-mediated tumor radiosensitization is also covered. Finally, further challenges and outlooks in this field are discussed.

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SnWO4-based nanohybrids with full energy transfer for largely enhanced photodynamic therapy and radiotherapy

Cited by 80 publications

References 26 publications

A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy

A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy

Type I Photosensitizers Revitalizing Photodynamic Oncotherapy

Emerging Strategies of Nanomaterial‐Mediated Tumor Radiosensitization

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