Vitamin D status is associated with underweight and stunting in children aged 6–36 months residing in the Ecuadorian Andes

Mokhtar, Rana; Holick, Michael F.; Sempértegui, Fernando; Griffiths, Jeffrey K.; Estrella, Bertha; Moore, Lynn L.; Fox, Matthew P.; Hamer, Davidson H.

doi:10.1017/s1368980017002816

Cited by 40 publications

(48 citation statements)

References 64 publications

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“…Serum 25(OH)D was also correlated with length/height Z-score in HIV+ and HIV-children 1-7.9 years; children with better Z-scores had higher vitamin D concentrations. There is existing evidence that low serum 25(OH)D is more prevalent in stunted populations [30,31], which may be related to the integral role of vitamin D in muscle and bone metabolism [32]. However, maternal vitamin D status versus child vitamin D status may differentially affect the risk of growth faltering.…”

Section: Plos Onementioning

confidence: 99%

Vitamin D status, nutrition and growth in HIV-infected mothers and HIV-exposed infants and children in Botswana

et al. 2020

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Background Poor vitamin D status is a global health problem and common in patients with human immunodeficiency virus (HIV) in high-income countries. There is less evidence on prevalence of vitamin D deficiency and nutrition and growth in HIV-infected and-exposed children in lowand middle-income countries. Objectives To determine the vitamin D status in Batswana HIV-infected mothers and their children, differences among HIV-infected mothers and between HIV-exposed and-infected infants and children, and associations between vitamin D and disease-related outcomes, nutrition, and growth. Methods This was a cross-sectional study of HIV+ mothers and HIV-exposed infants and unrelated children (1-7.9 years). Serum 25-hydroxyvitamin D (25(OH)D) was measured, among other nutritional indicators, for mothers, infants and children. Vitamin D status for HIV-infected mothers and children, and an immune panel was assessed. History of HIV anti-retroviral medications and breastfeeding were obtained. Data were collected prior to universal combination antiretroviral therapy in pregnancy.

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Section: Plos Onementioning

confidence: 99%

Vitamin D status, nutrition and growth in HIV-infected mothers and HIV-exposed infants and children in Botswana

et al. 2020

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“…Similarly, 25-OH-D has several implications for the immune, nervous, cardiovascular and endocrine systems adequate functioning (2) . The 25-OH-D deficiency has a high prevalence in children and adolescents worldwide and it has been related to the risk of developing conditions, such as rickets, osteomalacia, asthma, autism, cancer, depression, obesity and metabolic syndrome, among others (3)(4)(5) . However, these associations have mainly been observed in observational studies, which are at high risk of confounding from other healthy behaviours as a decrease in sun exposure (due to a decrease in the 25-OH-D synthesis of the skin) and an insufficient intake of foods rich in 25-OH-D (6,7) .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vitamin D status and its association with overweight or obesity in a population of Colombian children and adolescents

et al. 2020

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The present study aimed to estimate the prevalence of 25-OH-D status (insufficiency and deficiency) in children and adolescents residing in Bucaramanga, Colombia and to determine its association with excess weight. A case–control study was nested in the SIMBA II cohort in children and adolescents between the ages of 11 and 20 years old. Cases were defined as those children and adolescents with overweight or obesity. The control group was composed of children and adolescents from the same population sample with similar sociodemographic and economic characteristics but without overweight or obesity diagnosis. 25-hydroxyvitamin D (25-OH-D) was quantified in serum using a chemiluminescent microparticle immunoassay. Logistic regression models were used to assess the association between vitamin D status and overweight or obesity adjusted for the main confounding variables. A total of 494 children and adolescents cases were 138 (52⋅17% boys and 47⋅83% girls; median age 16⋅0 [Q1 15; Q3 18]). The median BMI S-Score minors age in the cases was 1⋅36 [Q1 1⋅06; Q3 2⋅00] and BMI (kg/m2) 28⋅0 [Q1 26⋅2; Q3 30⋅8]. The prevalence of vitamin D in the cases was deficiency 16⋅67%, insufficiency 57⋅25%, sufficiency 26⋅09. 25-OH-D insufficiency was associated with overweight or obesity after adjusting for the main confounding variables (OR 1⋅73; 95% CI 1⋅05–2⋅84). Our study concludes that the 25-OH-D insufficiency is common in children and adolescents in Bucaramanga, Colombia, and it was associated with overweight or obesity.

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“…Therefore, we investigated the association between serum 25-(OH)D concentration and WAZ and BAZ. Interestingly, we found a positive correlation between serum 25-(OH)D concentration and BAZ after adjusting for covariates, although some studies reported similar results [ 35 , 36 ]. An explanation for this finding is that BAZ is not a good representative of obesity in school-age children.…”

Section: Discussionmentioning

confidence: 50%

High Prevalence of Insufficient Vitamin D Intake and Serum 25-Hydroxyvitamin D in Chinese School-Age Children: A Cross-Sectional Study

et al. 2018

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Despite the importance of vitamin D in early stages of life, data are lacking on the levels of vitamin D intake and serum 25-hydroxyvitamin D (25-(OH)D) among Chinese school-age children. The aims of this study were to investigate the vitamin D intake and serum 25-(OH)D concentration of children aged 7 to 12 years in China, and to measure the associations between vitamin D status and children’s growth and development parameters. We obtained data on vitamin D intake, serum 25-(OH)D concentration, and anthropometric measurements from a cross-sectional study on school-aged children in China. Multiple linear regression and multivariable logistic regression analyses assessed the associations mentioned above. A total of 563 children (9.5 ± 1.6 years) from six areas of China were included. Among them, 86.1% had a vitamin D intake below the recommended nutrient intake (10 μg/day), and 54.7% had vitamin D deficiency (serum 25-(OH)D <15 ng/mL). We also found that high vitamin D intake was inversely associated with the risk of vitamin D deficiency (OR = 0.836, 95% confidence interval: 0.713, 0.980), and serum 25-(OH)D concentration was positively associated with the intelligence score and body mass index-for-age Z-score (BAZ) (p < 0.05). Insufficient vitamin D intake and serum 25-(OH)D are prevalent among Chinese school-aged children. A negative association was observed between vitamin D intake and the risk of vitamin D deficiency. Moreover, vitamin D status was positively associated with intelligence and BAZ, which await confirmation in future studies.

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Vitamin D status is associated with underweight and stunting in children aged 6–36 months residing in the Ecuadorian Andes

Abstract: Low serum 25(OH)D levels were more common in underweight and stunted Ecuadorian children.

Cited by 40 publications

References 64 publications

Vitamin D status, nutrition and growth in HIV-infected mothers and HIV-exposed infants and children in Botswana

Vitamin D status, nutrition and growth in HIV-infected mothers and HIV-exposed infants and children in Botswana

Prevalence of vitamin D status and its association with overweight or obesity in a population of Colombian children and adolescents

High Prevalence of Insufficient Vitamin D Intake and Serum 25-Hydroxyvitamin D in Chinese School-Age Children: A Cross-Sectional Study

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