Long-term remineralizing effect of MI Paste Plus on regression of early caries after orthodontic fixed appliance treatment: a 12-month follow-up randomized controlled trial

Beerens, Moniek W.; Cate, J.M. ten; Buijs, M.J.; Veen, Monique H. van der

doi:10.1093/ejo/cjx085

Cited by 26 publications

(20 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, our result was inconsistent with Huang et al (36) who concluded that "MI Paste Plus" and PreviDent fluoride varnish" didn't appear to be more effective than normal home care for improving the appearance of white spot lesions over eight weeks. This was also supported by Moniek et al (37) who stated that the additional use of "MI Paste Plus" in patients with subsurface enamel lesions after orthodontic fixed appliance treatment did not improve these lesions during the year following debonding. Our justification for the different findings between our study and theirs is the different shifts in salivary pH in patients that depend on various individual variations, most importantly the dietary habits and amount of sucrose ingested that can lower the salivary pH to a great extent.…”

Section: Discussionsupporting

confidence: 52%

Effectivenessof Casein Phospopeptide Amormphous Calcium Phosphate With or Without Fluoride on Reminelization of Enamel Caries- Like Lesions in Primary Teeth

Habashy

Heikal²

2020

Egyptian Dental Journal

View full text Add to dashboard Cite

Objective: To evaluate and compare the remineralization effect of casein phospho-peptide amorphous calcium phosphate with or without fluoride "MI paste"&"MI Paste Plus" respectively" on the re-mineralization of enamel caries-like lesions in primary teeth. Material and methods:Artificial caries lesion was made on the labial surface of 40 extracted or exfoliated sound primary teeth which were then divided into 2 halves; one half was treated with one of the tested remineralizing agent "MI paste" or "MI Paste Plus"" while the other half served as a control. The lesions were evaluated both qualitatively using a polarized light microscope and quantitatively by measuring "calcium and phosphate" content using "energy-dispersive X-ray spectroscopy". Data were collected and analyzed by using paired t-test to compare the control and the study groups for each material, while the "t-test" was used to compare between the two study groups.Results: Both "MI paste" and "MI Paste Plus" showed significant re-mineralization to the subsurface enamel lesions. "MI Paste Plus" showed significantly better results than "MI paste" with an increased amount of calcium "t=5.59 p=<0.0001", Ca/phosphate ratio "t=4.08 p=0.003" and reduction in the amount of phosphate content "t=4.57 p= 0.001". Conclusion:Both "MI paste" and "MI Paste Plus" were effective in enamel remineralization, the addition of fluoride in "MI Paste Plus" acted synergistically with the casein phospho-peptide amorphous calcium phosphate and gave better remineralization effect on enamel.

show abstract

Section: Discussionsupporting

confidence: 52%

Effectivenessof Casein Phospopeptide Amormphous Calcium Phosphate With or Without Fluoride on Reminelization of Enamel Caries- Like Lesions in Primary Teeth

Habashy

Heikal²

2020

Egyptian Dental Journal

View full text Add to dashboard Cite

show abstract

“…Fluoride delivery comes in different forms, such as fluoride varnishes, or toothpastes, mouth-rinses, and gels containing fluoride, as well as orthodontic bonding adhesives/cements incorporating a source of fluoride [ 7 , 8 ]. Other recent approaches to reduce white spot formation include the application of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP), bioactive glass, or addition of nano-particles with anti-caries activities to the orthodontic appliance surfaces or orthodontic adhesives/cements [ 2 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Shear Bond Strength and Antibacterial Activity of Orthodontic Adhesive Containing Silver Nanoparticle, an In-Vitro Study

et al. 2020

View full text Add to dashboard Cite

This study evaluated the effect of incorporating silver nanoparticles (AgNPs) into conventional orthodontic adhesive on its antibacterial activity and the shear bond strength (SBS) to stainless steel orthodontic brackets. Thirty-four extracted premolars were randomly allocated into two groups (n = 17). Orthodontic adhesive (Transbond XT, 3M Unitek) was blended with AgNPs (50 nm, 0.3% w/w) to form a nano-adhesive. In order to bond stainless steel twin brackets (0.022-inch, American Orthodontics), Transbond XT (n = 17) and nano-adhesive (n = 17) were used in each group, respectively, after acid etching (37% phosphoric acid, 30 s) and rinsing with water (15 s). SBS and the adhesive remnant index (ARI) scores were recorded. Antibacterial activity against Streptococcus mutans in both groups after 24 h and 30 days was assessed (Disc agar diffusion test) and the inhibition zone diameter around each specimen was measured and recorded. Adding AgNPs significantly (p = 0.009) reduced the mean (SD) SBS in the nano-adhesive group [10.51(7.15) MPa] compared to Transbond XT [17.72(10.55) MPa]. The ARI scores on the Transbond XT and nano-adhesive showed no statistically significant difference (p = 0.322). Nano-adhesive with AgNPs showed significant antibacterial activity against Streptococcus mutans at 24 h and 30 days (p < 0.001). In both groups, no significant decline in the zones of inhibition was detected after 30 days (p = 0.907). The findings suggest that SBS decreased after incorporation of AgNPs [0.3% (w/w)], but was still above the recommended SBS of 5.9–7.8 MPa. The nano-adhesive showed significant antibacterial activity which did not change much after 30 days.

show abstract

“…In order to deal with the clearing effect of saliva, lozenges or chewing gum containing CPP-ACP(F) are an alternative for creams. In situ randomized research showed that sugar free gum containing CPP-ACP promoted greater remineralization levels 36 …”

Section: Discussionmentioning

confidence: 99%

The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

Thierens¹,

Moerman²,

Elst³

et al. 2019

J. Appl. Oral Sci.

View full text Add to dashboard Cite

Objective: The aim of this in vitro study was to determine the effects of remineralization promoting agents containing casein phosphopeptide-stabilized amorphous calcium phosphate (CPP-ACP), or CPP-ACP in combination with fluoride (CPP-ACPF) on artificial white spot lesions (WSLs) after 6 and 12 weeks. Methodology: White spot lesions were created on 123 sectioned premolars (246 specimens) with a demineralization solution during a 96 hours pH-cycling regime. Two experimental groups were created: a CPP-ACP group (Tooth Mousse™), and a CPP-ACPF group (Mi Paste Plus™). Additionally, two control groups were created, one using only a conventional toothpaste (1450 ppm fluoride) and another one without any working agents. All teeth were also daily brushed with the conventional toothpaste except the second control group. Tooth Mousse™ and Mi Paste Plus™ were applied for 180 seconds every day. The volume of demineralization was measured with transverse microradiography. Six lesion characteristics regarding the lesion depth and mineral content of WSLs were also determined. Results: The application of CPP-ACP and CPP-ACPF had a significant regenerative effect on the WSLs. Compared to Control group 1 and 2 the volume of demineralization after 6 weeks decreased significantly for CPP-ACP (respectively p <0.001 and p <0.001) and CPP-ACPF (respectively p =0.001 and p =0.003). The same trend was observed after 12 weeks. For the CPP-ACPF group, WSL dimensions decreased significantly between 6 and 12 weeks follow-up ( p =0.012). The lesion depth reduced significantly after application of CPP-ACP and CPP-ACPF but increased significantly in the Control groups. Mineral content increased for CPP-ACP and CPP-ACPF after an application period of 12 weeks, but this was only significant for CPP-ACP. Conclusions: Long-term use of CPP-ACP and CPP-ACPF in combination with a conventional tooth paste shows beneficial effects in the recovery of in vitro subsurface caries lesions.

show abstract

Long-term remineralizing effect of MI Paste Plus on regression of early caries after orthodontic fixed appliance treatment: a 12-month follow-up randomized controlled trial

Cited by 26 publications

References 29 publications

Effectivenessof Casein Phospopeptide Amormphous Calcium Phosphate With or Without Fluoride on Reminelization of Enamel Caries- Like Lesions in Primary Teeth

Effectivenessof Casein Phospopeptide Amormphous Calcium Phosphate With or Without Fluoride on Reminelization of Enamel Caries- Like Lesions in Primary Teeth

Evaluation of the Shear Bond Strength and Antibacterial Activity of Orthodontic Adhesive Containing Silver Nanoparticle, an In-Vitro Study

The in vitro remineralizing effect of CPP-ACP and CPP-ACPF after 6 and 12 weeks on initial caries lesion

Contact Info

Product

Resources

About