Smoking cessation leads to changes in survivin expression in oral mucosa

Lima, Carlos H. M. de; Crastechini, Érica; Santos, Nathalia Curto dos; Ribeiro, Ana Carolina Prado; Brandão, Thaís Bianca; Castro, Félix C. F.; Issa, Jaqueline Schölz; Almeida, Janete Días

doi:10.1111/jop.12664

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Apoptosis1

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Cited by 2 publications

(2 citation statements)

References 28 publications

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“…As such a procedure is only minimally painful, it is not necessary to use local anesthesia when performing it. Samples were collected from border of the tongue, which is one of the most affected by OSCC intra-oral sites (Lima et al, 2017;Pires et al, 2013).…”

Section: Sample Collectionmentioning

confidence: 99%

Screening methylation of DNA repair genes in the oral mucosa of chronic smokers

Carta

Alves

Barros

et al. 2018

Archives of Oral Biology

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Section: Sample Collectionmentioning

confidence: 99%

Screening methylation of DNA repair genes in the oral mucosa of chronic smokers

Carta

Alves

Barros

et al. 2018

Archives of Oral Biology

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“…Münscher et al found survivin was expressed at high levels in HNSCC, and positively correlated with the malignant characteristics (75). Another study reported that nicotine reduced cisplatin-induced apoptosis in oral cancer cells, while this protective effect could be attenuated when survivin was inhibited (76). YM155 is a small molecule inhibitor of survivin that has been found to be effective and selective in recent years.…”

Section: Apoptosismentioning

confidence: 99%

The Molecular Basis and Therapeutic Aspects of Cisplatin Resistance in Oral Squamous Cell Carcinoma

Cheng

Gao

et al. 2021

Front. Oncol.

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Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the management of advanced OSCC, cisplatin-based chemotherapy or chemoradiotherapy has been considered as the first-line treatment. Unfortunately, only a portion of OSCC patients can benefit from cisplatin treatment, both inherent resistance and acquired resistance greatly limit the efficacy of cisplatin and even cause treatment failure. Herein, this review outline the underlying mechanisms of cisplatin resistance in OSCC from the aspects of DNA damage and repair, epigenetic regulation, transport processes, programmed cell death and tumor microenvironment. In addition, this review summarizes the strategies applicable to overcome cisplatin resistance, which can provide new ideas to improve the clinical therapeutic outcome of OSCC.

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Smoking cessation leads to changes in survivin expression in oral mucosa

Abstract: The extension and intensity of survivin expression in the cytological smears were related to the smoking cessation in the group with OSCC. However, the smoking history (packs/years) did not influence the survivin expression.

Cited by 2 publications

References 28 publications

Screening methylation of DNA repair genes in the oral mucosa of chronic smokers

Screening methylation of DNA repair genes in the oral mucosa of chronic smokers

The Molecular Basis and Therapeutic Aspects of Cisplatin Resistance in Oral Squamous Cell Carcinoma

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