A comparative proteomic study of secretomes in kaempferitrin-treated CTX TNA2 astrocytic cells

Beneficial Biological Activities of Cinnamomum osmophloeum and Its Potential Use in the Alleviation of Oral Mucositis: A Systematic Review

“…Specific studies (2 to 4) discussed the beneficial biological activities [3,[18][19][20][21][22] and suggested more than one chemical compound as the active content. Some beneficial biological activities have been summarized in Table 1 and consist of anti-inflammatory activities [20,[22][23][24][25][26][27][28][29][30], wound repair activities [20], antibacterial activities [31,32], antifungal activities [33,34], antioxidant activities [18,20,[35][36][37], anti-hyperglycemic activities [3,18,21], antidyslipidemia activities [38,39], anti-cancer and anti-tumor activities [22], renal disease therapy, and anti-hyperuricemia activities [2,4]. In addition, studies on the leaves, twigs, barks, heartwoods, and roots of C. osmophloeum were also reported.…”

“…Numerous studies reported the anti-inflammatory effect of C. osmophloeum [24][25][26][28][29][30]40] and they have been applied to the medical treatment of animal organs, such as endotoxin-induced intestinal injury [27], pancreas protection [3], and lipopolysaccharide/D-galactosamine (LPS/D-GaIN)-induced acute hepatitis [6]. Some of these studies identified the specific constituents of C. osmophloeum that accounted for the anti-inflammatory effect [23,26,28,30,40]. For example, Kaempferitin, a constituent of C. osmophloeum, was reported to be an anti-inflammatory that could down-regulate the extracellular LDL-R (Low-Density Lipoprotein-Receptor), followed by ameliorating subsequent chronic inflammation-related diabetes mellitus [26].…”

“…Some of these studies identified the specific constituents of C. osmophloeum that accounted for the anti-inflammatory effect [23,26,28,30,40]. For example, Kaempferitin, a constituent of C. osmophloeum, was reported to be an anti-inflammatory that could down-regulate the extracellular LDL-R (Low-Density Lipoprotein-Receptor), followed by ameliorating subsequent chronic inflammation-related diabetes mellitus [26]. Several constituents of C. osmophloeum, including trans-cinnamaldehyde, caryophyllene oxide, L-borneol, L-bornyl acetate, eugenol, β-caryophyllene, E-nerolidol, and cinnamyl, were demonstrated to be anti-inflammatory, which could suppress the synthesis of nitric oxide (NO) by LPS-stimulated macrophages through an identical mechanism [29,30].…”

“…Anti-inflammatory activity studies of C. osmophloeum have also been applied systemically in specific disease treatment [3,22,27,40]. Numerous mechanisms of inhibiting inflammation, including the compositional contents, mechanisms, anatomical parts, and promising investigations, have also been reported elsewhere [22][23][24][25][26]28,40,45].…”

“…Flavanoid-rich fractions containing kaempferitin in Bauhinia forficata leaves have been investigated and shown to be effective ingredients for preventing the intestinal toxic effects of irinotecan chemotherapy. It was stated that kaempferitin, as one of the major active contents of C. osmophloeum, has been tested to prevent or reduce the severity of intestinal mucositis [26,90]. The chemotherapy drug 5-Fluororacil possesses side effects (i.e., induces mucositis manifestations in oral and gastrointestinal after chemotherapy).…”