Correction: Urinary incontinence in women

Aoki, Yoshitaka; Brown, Heidi W.; Brubaker, Linda; Cornu, Jean Nicolas; Daly, J Oliver; Cartwright, Rufus

doi:10.1038/nrdp.2017.97

Cited by 34 publications

(13 citation statements)

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“…Female stress urinary incontinence (FSUI) is in women the most prevalent form of incontinence, well above overactive bladder or overflow incontinence, affecting over 200 million women worldwide [1,2]. It occurs mainly in postmenopausal women, during pregnancy, childbirth, and low estrogen level, severely impairing their quality of life [3].…”

Section: Introductionmentioning

confidence: 99%

Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo

Kovanecz

Gelfand

Lin

et al. 2019

IJMS

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Female stress urinary incontinence (FSUI) is prevalent in women with type 2 diabetes/obesity (T2D/O), and treatment is not optimal. Autograph stem cell therapy surprisingly has poor efficacy. In the male rat model of T2D/O, it was demonstrated that epigenetic changes, triggered by long-term exposure to the dyslipidemic milieu, led to abnormal global transcriptional signatures (GTS) of genes and microRNAs (miR), and impaired the repair capacity of muscle-derived stem cells (MDSC). This was mimicked in vitro by treatment of MDSC with dyslipidemic serum or lipid factors. The current study aimed to predict whether these changes also occur in stem cells from female 12 weeks old T2D/O rats, a model of FSUI. MDSCs from T2D/O (ZF4-SC) and normal female rats (ZL4-SC) were treated in vitro with either dyslipidemic serum (ZFS) from late T2D/O 24 weeks old female Zucker fatty (ZF) rats, or normal serum (ZLS) from 24 weeks old female Zucker lean (ZL) rats, for 4 days and subjected to assays for fat deposition, apoptosis, scratch closing, myostatin, interleukin-6, and miR-GTS. The dyslipidemic ZFS affected both female stem cells more severely than in the male MDSC, with some gender-specific differences in miR-GTS. The changes in miR-GTS and myostatin/interleukin-6 balance may predict in vivo noxious effects of the T2D/O milieu that might impair autograft stem cell (SC) therapy for FSUI, but this requires future studies.

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Section: Introductionmentioning

confidence: 99%

Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo

Kovanecz

Gelfand

Lin

et al. 2019

IJMS

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“…However, the efficacy of the model is limited by the small sample size, the combined study property of cesarean and vaginal delivery, and the lack of validation. Pregnancy and delivery are most important risk factors of SUI [ 27 , 28 ], and there were significant differences in baseline factors between cesarean and vaginal deliveries. In the present study, we created a nomogram in a larger cohort based on a detailed collection of obstetrical and especially labor-related factors, which have been well validated both internally and externally.…”

Section: Discussionmentioning

confidence: 99%

“…Prolonged second stage of labor was shown to be another important predictor of postpartum SUI by our study and previous studies [ 33 – 35 ]. The anatomical support of the bladder neck and the urethra may be lessened if damage to the arcus tendineus fasciae pelvis or paravaginal tissue occurs as a result of excessive loading from the continuously descending fetal head [ 27 ]. Therefore, it indicates that both the increased number of impairments and the prolonged duration of stress on the pelvic floor structure are associated with the onset of postpartum SUI.…”

Section: Discussionmentioning

confidence: 99%

Establishment and validation of a simple nomogram for predicting early postpartum stress urinary incontinence among women with vaginal delivery: a retrospective study

Guo

Chi

et al. 2023

BMC Women's Health

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Background Stress urinary incontinence (SUI) is a common public health issue that negatively impacts the quality of life for women worldwide, of which early detection and rehabilitation are consequently pivotal. The aim of this study is to establish a simple nomogram for identifying women at risk of postpartum SUI. Methods A retrospective study was conducted in a tertiary specialized hospital in Shanghai, China. The study included only women with singleton, full-term, and vaginal deliveries. 2,441 women who delivered from July 2019 to November 2019 were included in the training cohort, and 610 women who delivered from January 2022 to February 2022 were included in the validation cohort. SUI was determined by the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI-SF). Univariate and multifactorial logistical regression were used to identify independent risk factors for postpartum SUI and further construct the nomogram accordingly. Based on concordance statistics (C-statistics), calibration curves, and decision curve analyses, we evaluated the performance of the nomogram in the training cohort and the validation cohort. In addition, the model was validated internally in the training cohort through cross-validation. Results There were no significant statistically differences in important baseline data such as age, pre-pregnancy BMI, and parity between the training and validation cohorts. SUI was observed in 431 (17.6%) and 125 (20.5%) women in the training and validation cohorts, respectively. According to the regression analysis, age, parity, second stage of labor, infant weight, and forceps delivery were included in the nomogram. The nomogram had a C-statistic of 0.80 (95% confidence interval [CI] 0.74–0.85) for predicting SUI. C-statistics were stable in both internally cross-validated training cohort (mean 0.81) and validation cohort (0.83 [95% CI 0.79–0.87]). The nomogram’s calibration curve was near the ideal diagonal line. Additionally, the model exhibited a positive net benefit from the decision curve analysis. Conclusion We have created a nomogram that can be utilized to quantify the risk of postpartum SUI for women with vaginal delivery. The model might contribute to predicting early postpartum SUI, thereby facilitating the management of SUI.

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“…Urgency urinary incontinence (UUI), a geriatric syndrome defined as the leakage of urine associated with the sudden desire to void has been a growing health problem in the older adult population for many years ( Aoki et al, 2017 ) The Centers for Disease Control and Prevention (CDC) reports that more than 51% of community-dwelling women aged 65 years and older experienced urinary leakage in 2014, with 12% reporting severe or very severe symptoms of bladder incontinence ( Gorina et al, 2014 ). Symptoms of UUI have been shown to be more prevalent in those aged 75 and older compared to those 65 to 74 years of age ( Gorina et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Factors Associated With Urgency Urinary Incontinence Among Older Mexican American Women Aged 65 years and Older

Martinez

Rodríguez

snih

2022

Gerontology and Geriatric Medicine

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The purpose of this study was to determine which socio-demographic, clinical, or functional factors are associated with urgency urinary incontinence (UUI) over 20-years of follow-up in a community-dwelling sample of Mexican American women aged 65 years and older without UUI at baseline. We included 1,358 women participants from the Hispanic Established Population for the Epidemiologic Study of the Elderly study conducted in the southwestern of US (Arizona, California, Colorado, New Mexico, and Texas). Measures included self-reported UUI, socio-demographics, smoking status, body mass index, medical conditions, depressive symptoms, physical and cognitive function, and handgrip strength. We used generalized estimating equation models to estimate the odds ratio (OR) and 95% Confidence Interval (CI) of UUI as a function of socioeconomic, clinical, and functional factors. Self-reported UUI increased from 3.1% to 21.9% from baseline (1993/1994) to follow-up (2012/2013). Current smokers, obesity, arthritis, previous heart attacks, and depressive symptoms were factors associated with greater odds of UUI over time. Identification of these factors can help clinicians determine those at high risk of developing UUI. Preventing and/or treating the risk factors early may delay UUI and increase quality of life in this underserved population.

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Correction: Urinary incontinence in women

Cited by 34 publications

References 0 publications

Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo

Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence Are Damaged by In Vitro Exposure to its Dyslipidemic Serum, Predicting Inadequate Repair Capacity In Vivo

Establishment and validation of a simple nomogram for predicting early postpartum stress urinary incontinence among women with vaginal delivery: a retrospective study

Factors Associated With Urgency Urinary Incontinence Among Older Mexican American Women Aged 65 years and Older

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