Antimicrobial and Osseointegration Properties of Nanostructured Titanium Orthopaedic Implants

Jäger, Markus; Jennissen, H. P.; Dittrich, F; Fischer, Alfons; Köhling, Hedda Luise

doi:10.3390/ma10111302

Cited by 96 publications

(77 citation statements)

References 199 publications

(167 reference statements)

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“…The obtained morphology of nanotubular layer is compatible with reports on cell adhesion on TiO 2 nanotubes: a small TNT diameter (~30 nm) stimulated the highest degree of osteoblast adhesion [29], diameters of 15-20 nm increased cell adhesion, proliferation as well as alkaline phosphatase (ALP) activity and bone matrix deposition [30]; higher spreading of cytoskeletal actin was found on the surface with a small nanotube diameter (30 nm) [31]. To our knowledge, the influence of titania nanotubes length on cell adhesion has not yet been reported.…”

Section: Anodizing Of Ti6al4v Eli Transpedicular Screwssupporting

confidence: 86%

Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

2020

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Nano-engineered implants are a promising orthopedic implant modification enhancing bioactivity and integration. Despite the lack of destruction of an oxide layer confirmed in ex vivo and in vivo implantation, the testing of a microrupture of an anodic layer initiating immune-inflammatory reaction is still underexplored. The aim of this work was to form the compact and nanotubular oxide layer on the Ti6Al4V ELI transpedicular screws and electrochemical detection of layer microrupture after implantation ex vivo by the Magerl technique using scanning electron microscopy and highly sensitive electrochemical methods. For the first time, the obtained results showed the ability to form the homogenous nanotubular layer on an Ti6Al4V ELI screw, both in α and β-phases, with favorable morphology, i.e., 35 ÷ 50 ± 5 nm diameter, 1500 ± 100 nm height. In contrast to previous studies, microrupture and degradation of both form layers were observed using ultrasensitive electrochemical methods. Mechanical stability and corrosion protection of nanotubular layer were significantly better when compared to compact oxide layer and bare Ti6Al4V ELI.

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Section: Anodizing Of Ti6al4v Eli Transpedicular Screwssupporting

confidence: 86%

Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

2020

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“…Orthopaedic implants are used to replace or support a damaged bone tissue or joint. These internal fixators are mostly in the form of plates, screws, nails, or wires generally made of stainless steel and titanium alloys [1][2][3][4]. In the case of temporary metallic implants, the use of these conventional materials necessitates a second surgery to remove the implant after recovery.…”

Section: Introductionmentioning

confidence: 99%

Effect of grain refinement on biodegradation and biomineralization of low calcium containing Mg–Ca alloy

Shishir¹,

Rahim²,

Hanas³

2020

Mater. Res. Express

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The biodegradability and mechanical properties of magnesium make it suitable for temporary implant applications. However, its degradation rate in the physiological environment needs to be controlled. The effect of grain refinement on the degradation rate in the physiological environment is investigated in this work. Samples with different grain size were developed by heat treatment and friction stir processing (FSP) techniques. Potentiodynamic polarization test in NaCl solution and immersion test in supersaturated simulated body fluid (SSBF) were conducted to evaluate the degradation resistance of the samples. The effect of grain refinement on biomineralization was also studied by analysing the surface morphology and composition of the immersion tested samples using SEM and EDAX. It is noted that the grain refinement improves the degradation resistance as well as biomineralization. The enhancement in the biomineralization resulted in the development of a calcium phosphate layer on the surface during the immersion test, which in turn reduced the degradation rate further. Hence grain refinement can be used as an effective metallurgical modification technique to tailor the degradation rate of Mg-Ca alloys in the physiological environment.

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“…These are characterized by initial protein adsorption followed by cellular attachment and adherence leading to migration, differentiation, and proliferation of local cells. Mediated by cytokines and biomechanical forces, subsequent biomineralization and bone remodeling occur . Since rapid osteointegration is a prerequisite for early weight bearing after total hip replacement, detailed knowledge of the initial protein film deposit onto the implant may help to understand and predict the latter response of the osseous microenvironment to implant surfaces.…”

Section: Introductionmentioning

confidence: 99%

Intrasurgical Protein Layer on Titanium Arthroplasty Explants: From the Big Twelve to the Implant Proteome

Jäger

Jennissen

Haversath

et al. 2019

Proteomics Clinical Apps

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Purpose: Aseptic loosening in total joint replacement due to insufficient osteointegration is an unsolved problem in orthopaedics. The purpose of the study is to obtain a picture of the initial protein adsorption layer on femoral endoprosthetic surfaces as the key to the initiation of osseointegration. Experimental design: The paper describes the first study of femoral stem explants from patients for proteome analysis of the primary protein layer. After 2 min in situ, the stems are explanted and frozen in liquid nitrogen. Proteins are eluted under reducing conditions and analyzed by LC-MS/MS. Results: After exclusion of proteins identified by a single peptide, the implant proteome is found to consist of 2802 unique proteins. Of these, 77% are of intracellular origin, 9% are derived from the plasma proteome, 8% from the bone proteome, and four proteins with highest specificity score could be assigned to the bone marrow proteome (transcriptome). The most abundant protein in the adsorbed total protein layer is hemoglobin (8-11%) followed by serum albumin (3.6-6%). Conclusions: A detailed knowledge of the initial protein film deposited onto the implants, as demonstrated here for the first time, may help to understand and predict the response of the osseous microenvironment to implant surfaces.

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Antimicrobial and Osseointegration Properties of Nanostructured Titanium Orthopaedic Implants

Cited by 96 publications

References 199 publications

Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

Electrochemical Evaluation of the Compact and Nanotubular Oxide Layer Destruction under Ex Vivo Ti6Al4V ELI Transpedicular Screw Implantation

Effect of grain refinement on biodegradation and biomineralization of low calcium containing Mg–Ca alloy

Intrasurgical Protein Layer on Titanium Arthroplasty Explants: From the Big Twelve to the Implant Proteome

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