Evaluación del suplemento de vitaminas C y E en el tratamiento antibiótico contra Helicobacter pylori : revisión sistemática y metaanálisis

Caicedo, Yaset; Moreno, Cesar; Fandiño, Yardany Rafael Méndez; Fonseca, Sofía; Motta, Héctor Fabio Cortes; Guerra, Santiago

doi:10.1016/j.medcli.2017.09.014

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…The duration of pneumonia may also be reduced after vitamin C supplementation in adults, an effect that is dose-dependent [203]. No benefits have been observed in hospital-acquired pneumonia in adults after supplementation with vitamin C [203], or in the eradication rate of Helicobacter pylori with either vitamin C with vitamin E or vitamin C alone in adults [217,218].…”

Section: Micronutrients In the Management Of Acute Infectionsmentioning

confidence: 99%

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

2020

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Immune support by micronutrients is historically based on vitamin C deficiency and supplementation in scurvy in early times. It has since been established that the complex, integrated immune system needs multiple specific micronutrients, including vitamins A, D, C, E, B6, and B12, folate, zinc, iron, copper, and selenium, which play vital, often synergistic roles at every stage of the immune response. Adequate amounts are essential to ensure the proper function of physical barriers and immune cells; however, daily micronutrient intakes necessary to support immune function may be higher than current recommended dietary allowances. Certain populations have inadequate dietary micronutrient intakes, and situations with increased requirements (e.g., infection, stress, and pollution) further decrease stores within the body. Several micronutrients may be deficient, and even marginal deficiency may impair immunity. Although contradictory data exist, available evidence indicates that supplementation with multiple micronutrients with immune-supporting roles may modulate immune function and reduce the risk of infection. Micronutrients with the strongest evidence for immune support are vitamins C and D and zinc. Better design of human clinical studies addressing dosage and combinations of micronutrients in different populations are required to substantiate the benefits of micronutrient supplementation against infection.

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Section: Micronutrients In the Management Of Acute Infectionsmentioning

confidence: 99%

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

2020

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The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System

Nabavi-Rad

Azizi

Jamshidizadeh

et al. 2022

Journal of Immunology Research

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Helicobacter pylori as a class I carcinogen is correlated with a variety of severe gastroduodenal diseases; therefore, H. pylori eradication has become a priority to prevent gastric carcinogenesis. However, due to the emergence and spread of multidrug and single drug resistance mechanisms in H. pylori, as well as serious side effects of currently used antibiotic interventions, achieving successful H. pylori eradication has become exceedingly difficult. Recent studies expressed the intention of seeking novel strategies to improve H. pylori management and reduce the risk of H. pylori-associated intestinal and extragastrointestinal disorders. For which, vitamin supplementation has been demonstrated in many studies to have a tight interaction with H. pylori infection, either directly through the regulation of the host inflammatory pathways or indirectly by promoting the host immune response. On the other hand, H. pylori infection is reported to result in micronutrient malabsorption or deficiency. Furthermore, serum levels of particular micronutrients, especially vitamin D, are inversely correlated to the risk of H. pylori infection and eradication failure. Accordingly, vitamin supplementation might increase the efficiency of H. pylori eradication and reduce the risk of drug-related adverse effects. Therefore, this review aims at highlighting the regulatory role of micronutrients in H. pylori-induced host immune response and their potential capacity, as intrinsic antioxidants, for reducing oxidative stress and inflammation. We also discuss the uncovered mechanisms underlying the molecular and serological interactions between micronutrients and H. pylori infection to present a perspective for innovative in vitro investigations, as well as novel clinical implications.

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Association between dietary antioxidant index and risk of Helicobacter pylori infection among adults: a case–control study

et al. 2022

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Backgrounds and aims One of the most important risk factors for Helicobacter pylori (H. pylori) infection is nutrition. Balanced diets with high antioxidant properties may have protective effects against the consequences of this infection. In the current study, we aimed to investigate the association between the dietary antioxidant index and the risk of H. pylori infection among adults. Methods In a case–control study the dietary intake of patients with H. pylori infection was compared with healthy subjects. The dietary antioxidant index (DAI) was calculated using dietary intakes derived from a validated food frequency questionnaire (FFQ). Demographic information was obtained by a related questionnaire and Physical Activity was measured by International Physical Activity Questionnaire (IPAQ) were used to obtain information. Using logistic regression models, we evaluated the association between the DAI and H. pylori infection risk. The significance level was determined as P < 0.05. Results Finally, dietary data of 148 cases and 302 controls (mean age: 38.72 ± 10.61 (were analyzed. The mean of total DAI was significantly higher in controls (7.67) when compared with H. pylori cases (3.57) (P < 0.001). After adjustment for covariates, participants with less than median DAI values had an increased risk of H. pylori onset (adjusted OR 1.08, 95% CI: 1.02–1.12, P < 0.001). Conclusions Appropriate intake of nutrient antioxidants may have a role in decreasing the likelihood of H. pylori infection risk.

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Evaluación del suplemento de vitaminas C y E en el tratamiento antibiótico contra Helicobacter pylori : revisión sistemática y metaanálisis

Cited by 4 publications

References 39 publications

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection

The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System

Association between dietary antioxidant index and risk of Helicobacter pylori infection among adults: a case–control study

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