Shape Tailored Magnetic Nanorings for Intracellular Hyperthermia Cancer Therapy

Abstract

AbstarctThis work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heating power while fulfilling the main requirements for biomedical applications (low cytotoxicity and nonremanent state). In addition, the present work demonstrates that the synthesized VIPs also promote an internalization and aggregation of the particles inside the cell, resulting in a highly localized hyperthermia in the presence of an alternating magnetic field. Thereby, we demonstrate a new and efficient magnetic hyperthermia strategy in which a small, but well localized, concentration of VIPs can promote an intracellular hyperthermia process.

Toward Biomaterials for Enhancing Immune Checkpoint Blockade Therapy

“…In order to achieve maximum therapeutic effects, the function of antigenicity, adjuvanticity, and feedback inhibition, three important factors in reactivating an antitumor immune response, should be comprehensively coordinated when designing efficient collaborative strategies . Tailoring biomaterials to integrate multiple other therapies such as gene therapy, cell therapy, magnetic fluid hyperthermia, and so on will provide great promise in the development of ICB therapy. Considering the relatively low response rate associated with ICB, identification of predictive and pharmacodynamic biomarkers will be crucial to guide the choice of inhibitor .…”

A microscopic approach to heating rate of ferrofluid droplets by a magnetic field

“…In fact, one of these applications is the so-called magnetic hyperthermia (MH), where the ferrofluid is used to provide the heating of a system. [1][2][3][4][5][6][7][8][9][10][11] When an external magnetic field is applied, induced magnetization lags the external field which results in heat dissipation at the fluid. Ferrofluids can be of interest in the construction of combustion chambers, whose projected size increases with the time taken for heating, vaporization, and consequently, burning of the fuel droplets.…”

Encapsulamento De Nanopartículas De Magnetita Em Sílica Visando Aplicação Em Hipertermia Magnética

“…De entre as possibilidades de aplicação desse sistema nanoparticulado tem-se seu uso no tratamento de câncer por hipertermia magnética. Esta técnica consiste em aplicar na região do tumor um campo magnético alternado externo capaz de promover um aumento da temperatura local para valores entre 41 e 45 ºC por interação com as nanopartículas magnéticas, sendo tal temperatura capaz de ocasionar a morte das células cancerígenas (Dias et al, 2017).…”