Guidelines for the management of acne: recommendations from a French multidisciplinary group

Cleach, Laurence Le; Lebrun‐Vignes, Bénédicte; Bachelot, Anne; Beer, F.; Berger, Paul R.; Brugere, Solange; Chastaing, M.; Do‐Pham, G.; Ferry, Tristan; Gand-Gavanou, J.; Guigues, B.; Join‐Lambert, Olivier; Henry, Patricia; Khallouf, R.; Lavie, Emilie; Maruani, Annabel; Romain, Olivier; Sassolas, B.; Tran, Viet‐Thi; Guillot, B.

doi:10.1111/bjd.15843

Cited by 43 publications

(40 citation statements)

References 16 publications

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“…Since the increase in antibiotic resistance became a major public concern, many acne treatment guidelines have encouraged the stewardship of antibiotic use . Topical antibiotics should be used in a limited setting and for a restricted duration.…”

Section: Discussionmentioning

confidence: 99%

“…Since the increase in antibiotic resistance became a major public concern, many acne treatment guidelines have encouraged the stewardship of antibiotic use. [4][5][6][7] Topical antibiotics should be used in a limited setting and for a restricted duration. Thus, using KTZ with an effect on AV comparable with topical clindamycin 26 but causing no risk of antibiotic resistance should be encouraged in the current practice.…”

Section: Discussionmentioning

confidence: 99%

“…Dermatologists are among the physicians most commonly prescribing antibiotics in the USA, and acne vulgaris (AV) is the most common indication . As a result, antibiotic stewardship has been strongly encouraged in several guidelines during the last few years …”

Section: Introductionmentioning

confidence: 99%

“…2,3 As a result, antibiotic stewardship has been strongly encouraged in several guidelines during the last few years. [4][5][6][7] Together with Cutibacterium acnes colonization, microbial dysbiosis, particularly Malassezia spp., has been acknowledged as an important factor in acne pathogenesis in AV. 8,9 Studies showed that the number of Malassezia spp.…”

Section: Introductionmentioning

confidence: 99%

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Topical 2% ketoconazole cream monotherapy significantly improves adult female acne: A double‐blind, randomized placebo‐controlled trial

Chottawornsak

Chongpison

Asawanonda

et al. 2019

The Journal of Dermatology

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The emergence of bacterial resistance is a global crisis. Prolonged use of antibiotics especially in acne is one issue of concern among dermatologists. Ketoconazole (KTZ) cream, a topical antifungal with anti‐inflammatory and antiandrogenic actions, can decrease lipase activity of Cutibacterium acnes in vitro. We evaluated the efficacy and safety of KTZ cream in mild adult female acne (AFA) by conducting a randomized, double‐blind, placebo‐controlled trial using KTZ 2% and placebo cream twice daily for 10 weeks. We assessed the improvement of clinical severity, measured by AFA score graded by investigators and participants, and the change of acne count. Forty‐one participants enrolled in our study. The proportion of participants with acne improvement from baseline (42.9% vs 9.5%, P = 0.015) and the success rate (45.0% vs 14.3%, P = 0.043) in the KTZ group were significantly higher than that of the placebo group. The most common adverse events were dryness and itching. The percentage change of acne count decreased significantly compared with baseline but did not differ statistically between the two groups (P = 0.268). We concluded that the KTZ monotherapy showed a plausible effect in improving AFA with excellent safety profile. It should be considered as a viable option for mild AFA treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Topical 2% ketoconazole cream monotherapy significantly improves adult female acne: A double‐blind, randomized placebo‐controlled trial

Chottawornsak

Chongpison

Asawanonda

et al. 2019

The Journal of Dermatology

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“…European Dermatology Forum, American Academy of Dermatology and numerous other national organizations. [1][2][3][4] Guidelines generally describe a systematic treatment escalation based on disease severity and treatment response; starting with topical treatments using e.g. benzoyl peroxide or retinoids, progressing over systemic therapies with antibiotics to isotretinoin.…”

Section: Introductionmentioning

confidence: 99%

Which acne treatment has the best influence on health‐related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes

Chernyshov

Tómas-Aragonés

Manolache³

et al. 2018

Acad Dermatol Venereol

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According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS), most of the publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO decided to detect which acne treatment has the best influence on HRQoL of acne patients. A new literature search was organized to find publications on acne treatment where the HRQoL of patients was assessed as an outcome measure. From 186 papers with HRQoL assessment, 37 papers were included for further analysis. Our results revealed that oral isotretinoin had the best influence on HRQoL of acne patients. Several other treatment methods also showed good effects on the HRQoL of acne patients. Oral isotretinoin and norethindrone acetate/ethinyl estradiol, topical clindamycin phosphate/benzoyl peroxide and adapalene/benzoyl peroxide showed significantly better effect on HRQoL than placebo. There is limited number of the high-quality studies on acne treatment where HRQoL was assessed. Dermatology-specific and acne-specific instruments showed much better sensitivity to successful therapeutic intervention than generic HRQoL instruments. The most frequently used HRQoL instrument was the Dermatology Life Quality Index questionnaire.

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Topical benzoyl peroxide for acne

Yang

Zhang

Mosler

et al. 2020

Cochrane Database of Systematic Reviews

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Guidelines for the management of acne: recommendations from a French multidisciplinary group

Abstract: Target population: Patients with acne, excluding newborns, acne secondary to hormonal diseases or induced acne. Management of acne scars are not within the scope of these guidelines.

Cited by 43 publications

References 16 publications

Topical 2% ketoconazole cream monotherapy significantly improves adult female acne: A double‐blind, randomized placebo‐controlled trial

Topical 2% ketoconazole cream monotherapy significantly improves adult female acne: A double‐blind, randomized placebo‐controlled trial

Which acne treatment has the best influence on health‐related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes

Topical benzoyl peroxide for acne

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