Topical benzoyl peroxide for acne

Yang, Zhirong; Zhang, Yuan; Mosler, Elvira Lazić; Hu, Jing; Li, Hang; Zhang, Yanchang; Liu, Jia; Zhang, Qian

doi:10.1002/14651858.cd011154.pub2

Cited by 32 publications

(14 citation statements)

References 172 publications

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“…Studies suggest that, while approximately 50% of facial acne patients also experience truncal acne, the trunk region tends to be overlooked in clinical trials [ 28 , 29 ]. The standard treatment option for truncal acne has been topical benzoyl peroxide, but there may be concern around the risk of bleaching clothes and the tendency toward skin irritation [ 29 , 30 ]. The results here suggest another option for those that are seeking treatment for truncal acne without an oral or systemic treatment.…”

Section: Discussionmentioning

confidence: 99%

Prospective Evaluation of a Topical Botanical Skin Care Regimen on Mild to Moderate Facial and Truncal Acne and Mood

Nong

Gahoonia

Rizzo

et al. 2023

JCM

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Acne vulgaris is a common inflammatory condition that can be associated with profound psychosocial impacts. Conventional treatment includes topical retinoids, benzoyl peroxide, and antimicrobials, and some may cause irritation and skin dryness. In this 8-week open-label study, we examined the effects of a botanical skin care regimen (Codex Labs Shaant Balancing regimen) on mild to moderate facial and truncal acne. Twenty-four male and female subjects between the ages of 12 and 45 years were assessed for eligibility, 20 were enrolled, and 15 completed all study visits. Facial and truncal acne lesion counts, skin hydration, sebum excretion rate, and mood were assessed at baseline, week 4, and week 8. Total facial lesion counts (inflammatory and non-inflammatory lesions) decreased by 20.5% at week 4 (p = 0.06) and by 25.2% at week 8 (p < 0.05). Inflammatory lesion counts on the trunk were found to decrease at week 8 relative to baseline by 48% (p < 0.05). Forehead sebum excretion rate decreased by 40% at week 4 (p = 0.07) and 22% at week 8 (p = 0.08), and cheek skin hydration increased by 27.6% at week 4 (p = 0.14) and 65% at week 8 (p = 0.10). Participants also experienced significant improvement in components of a positive effect, such as feeling “strong” and “inspired”, and a decrease in negative effects, such as feeling “irritable.” Overall, the botanical skin care regimen was found to be well-tolerated. Our study suggests that a botanical skin care regimen may reduce facial and truncal acne lesion counts, increase skin hydration, reduce sebum production, and augment positive effects and moods in those with mild to moderate facial and truncal acne.

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Section: Discussionmentioning

confidence: 99%

Prospective Evaluation of a Topical Botanical Skin Care Regimen on Mild to Moderate Facial and Truncal Acne and Mood

Nong

Gahoonia

Rizzo

et al. 2023

JCM

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“…In this meta-analysis, we found that BPO significantly reduced the amount of C. acnes in the skin, which is consistent with previous studies (23, 24). Theoretically, BPO and clindamycin (antibacterial) are synergistic in their activity (38)(39)(40). To better explore the method of BPO, we conducted a comparative analysis of BPO alone or combined with clindamycin, but the results showed no significant difference.…”

Section: Discussionmentioning

confidence: 99%

The safety and efficiency of benzoyl peroxide for reducing Cutibacterium acnes in the shoulder: An updated systematic review and meta-analysis

Fan

Ma²,

Liu³

et al. 2023

Front. Surg.

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BackgroundCutibacterium acnes (C. acnes), a common pathogen, contributes significantly to infections in shoulder surgery. Prevention of shoulder infection is crucial to improve postoperative functional recovery and reduce costs. This study aimed to perform a systematic review and meta-analysis to assess the safety and efficacy of 5% benzoyl peroxide (BPO) application in the shoulder to decrease C. acnes.MethodsThree electronic databases were searched as follows: PubMed, Embase, and the Cochrane Library databases. Data extraction for this study was performed by two independent reviewers, and only level I and level II studies were included. The outcome data sources of individual studies were pooled. The fixed-effect model was used to determine the meta-analysis.ResultsThere were five level I studies and five level II studies. The results showed that the 5% BPO group had a lower risk of C. acnes positivity [OR, 0.21 (0.15, 0.30), I2 = 24, p < 0.00001]. The pooled analysis results showed that there was no significant difference in the ability of 5% BPO and 5% BPO + clindamycin to reduce C. acnes. However, the lower rate of adverse events was significantly in favour of the non-BPO group compared with the 5% BPO group.ConclusionBPO can decrease C. acnes in the shoulder to prevent infection. However, the combination of BPO and clindamycin does not enhance this effect further.Level of evidenceII, Systematic review and meta-analysis.

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“…At these concentrations, both agents report few adverse effects, most often dryness, erythema, or pruritus, and much less commonly skin burns or anaphylaxis. 37,45…”

Section: Discussionmentioning

confidence: 99%

Efficacy of antimicrobial washes before shoulder surgery against Cutibacterium: a systematic review and meta-analysis

Collins

Simpson

Richey

et al. 2022

JSES Reviews, Reports, and Techniques

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Topical benzoyl peroxide for acne

Cited by 32 publications

References 172 publications

Prospective Evaluation of a Topical Botanical Skin Care Regimen on Mild to Moderate Facial and Truncal Acne and Mood

Prospective Evaluation of a Topical Botanical Skin Care Regimen on Mild to Moderate Facial and Truncal Acne and Mood

The safety and efficiency of benzoyl peroxide for reducing Cutibacterium acnes in the shoulder: An updated systematic review and meta-analysis

Efficacy of antimicrobial washes before shoulder surgery against Cutibacterium: a systematic review and meta-analysis

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