Quinic acid inhibits vascular inflammation in TNF-α-stimulated vascular smooth muscle cells

Jang, Seon‐A; Park, Dae Won; Kwon, Jeong Eun; Song, Hae Seong; Park, Bong‐Kyun; Jeon, Hyelin; Sohn, Eun‐Hwa; Koo, Hyun Jung

doi:10.1016/j.biopha.2017.10.021

Cited by 72 publications

(40 citation statements)

References 51 publications

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“…This indicates that QA improves beta‐cell function under diabetic stress (Arya et al, ). QA has also been shown to have anti‐inflammatory (Jang et al, ; Lee, Moon, Kim, & Lee, ) and antioxidant properties (Pero et al, ), which are both known to be beneficial in diabetic stress. However, one has to keep in mind that QA is metabolized already in the gut, so when QA is given in the diet, we cannot exclude the possibility that the anti‐diabetic effect might be mediated partly by metabolites or conjugates of QA.…”

Section: Discussionmentioning

confidence: 99%

The plant product quinic acid activates Ca²⁺‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

Heikkilä

Hermant

Thévenet

et al. 2019

British J Pharmacology

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Background and Purpose Quinic acid (QA) is an abundant natural compound from plant sources which may improve metabolic health. However, little attention has been paid to its effects on pancreatic beta‐cell functions, which contribute to the control of metabolic health by lowering blood glucose. Strategies targeting beta‐cell signal transduction are a new approach for diabetes treatment. This study investigated the efficacy of QA to stimulate beta‐cell function by targeting the basic molecular machinery of metabolism–secretion coupling. Experimental Approach We measured bioenergetic parameters and insulin exocytosis in a model of insulin‐secreting beta‐cells (INS‐1E), together with Ca2+ homeostasis, using genetically encoded sensors, targeted to different subcellular compartments. Islets from mice chronically infused with QA were also assessed. Key Results QA triggered transient cytosolic Ca2+ increases in insulin‐secreting cells by mobilizing Ca2+ from intracellular stores, such as endoplasmic reticulum. Following glucose stimulation, QA increased glucose‐induced mitochondrial Ca2+ transients. We also observed a QA‐induced rise of the NAD(P)H/NAD(P)+ ratio, augmented ATP synthase‐dependent respiration, and enhanced glucose‐stimulated insulin secretion. QA promoted beta‐cell function in vivo as islets from mice infused with QA displayed improved glucose‐induced insulin secretion. A diet containing QA improved glucose tolerance in mice. Conclusions and Implications QA modulated intracellular Ca2+ homeostasis, enhancing glucose‐stimulated insulin secretion in both INS‐1E cells and mouse islets. By increasing mitochondrial Ca2+, QA activated the coordinated stimulation of oxidative metabolism, mitochondrial ATP synthase‐dependent respiration, and therefore insulin secretion. Bioactive agents raising mitochondrial Ca2+ in pancreatic beta‐cells could be used to treat diabetes.

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Section: Discussionmentioning

confidence: 99%

The plant product quinic acid activates Ca²⁺‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

Heikkilä

Hermant

Thévenet

et al. 2019

British J Pharmacology

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“…The most abundant organic acids have been reported to have numerous bioactive functions. Quinic acid has demonstrated to have therapeutic properties, which include radio-protective activity, and anti-diabetic, anti-neuroinflammatory, and antioxidant effects, 26 while oxalic acid is one of the strongest and most abundant organic acids in nature, being studied among different research areas. This organic acid has demonstrated antioxidant properties and also the capacity of slowing down the aging of many fruits and vegetables.…”

Section: Chemical Composition Of Leavesmentioning

confidence: 99%

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

et al. 2019

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“…Ferulic acid ( 47 ) demonstrated mucosal membrane protection causing a significant reduction in ethanol-induced gastric ulcers. Quinic acid ( 1 ) has been shown to exhibit antioxidant and anti-neuroinflammatory activities [ 81 ]. Caffeoylquinic acid derivatives show anti-inflammatory activity by inhibiting the pro-inflammatory cytokines TNF- α and IL-1 β [ 82 ].…”

Section: Resultsmentioning

confidence: 99%

UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract

Elshamy¹,

Farrag

Ayoub

et al. 2020

Molecules

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Cyperus has been commonly used as a multi-use medicinal plant in folk medicine worldwide. The objectives of our study were to determine the different metabolites in the Cyperus conglomeratus Rottb. methanol extract, and to assess its in vivo gastroprotective effect in ethanol-induced gastric ulcer model in rats. Serum levels of galactin-3 and TNF-α were employed as biochemical markers. To pinpoint for active agents, comprehensive metabolites profiling of extract via UPLC-qTOF-MS/MS was employed. A total of 77 chromatographic peaks were detected, of which 70 were annotated. The detected metabolites were categorized into phenolic acids and their derivatives, flavonoids, stilbenes, aurones, quinones, terpenes, and steroids. Rats were divided into six groups; healthy control, ulcer control, standard drug group, and 25, 50, 100 mg/kg of C. conglomeratus treated rats. Pre-treatment with C. conglomeratus alcohol extract significantly reduced galactin-3, and TNF-α in ethanol-induced ulcer model at 25, 50, and 100 mg/kg. Further histopathological and histochemical studies revealed moderate erosion of superficial epithelium, few infiltrated inflammatory cells, and depletion of gastric tissue glycoprotein in the ulcer group. Treatment with the extract protected the gastric epithelial cells in a dose-dependent manner. It could be concluded that C. conglomeratus extract provides significant gastroprotective activity in ethanol-induced gastric ulcer and ought to be included in nutraceuticals in the future for ulcer treatment.

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Quinic acid inhibits vascular inflammation in TNF-α-stimulated vascular smooth muscle cells

Cited by 72 publications

References 51 publications

The plant product quinic acid activates Ca²⁺‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

The plant product quinic acid activates Ca²⁺‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract

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Quinic acid inhibits vascular inflammation in TNF-α-stimulated vascular smooth muscle cells

Cited by 72 publications

References 51 publications

The plant product quinic acid activates Ca2+‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

The plant product quinic acid activates Ca2+‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

Ocimum basilicum var. purpurascens leaves (red rubin basil): a source of bioactive compounds and natural pigments for the food industry

UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract

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Product

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The plant product quinic acid activates Ca²⁺‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells

The plant product quinic acid activates Ca²⁺‐dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells