Increased weight gain by C-section: Functional significance of the primordial microbiome

Martinez, Keith A.; Devlin, Joseph C.; Lacher, Corey; Yin, Yue; Cai, Yi; Wang, Jincheng; Domínguez-Bello, María Gloria

doi:10.1126/sciadv.aao1874

Cited by 78 publications

(61 citation statements)

References 26 publications

(24 reference statements)

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“…At the genus level, our results reflected that the relative abundances of Bifidobacterium, Bacteroides, Alistipes, Lachnospiraceae NK4A136 group and Alloprevotella decreased while that of Parabacteroides, Eubacterium xylanophilum group, GCA-900066575, Lachnoclostridium, Lachnospiraceae UCG-006 and Romboutsia increased in the HFD group compared with the control group. In line with our results, earlier studies found that the abundances of Bifidobacterium (Zhu et al, 2018), Bacteroides (Zhang et al, 2015;Martinez et al, 2017), Alistipes (Zhu et al, 2018), Lachnospiraceae NK4A136 group , and Alloprevotella were negatively correlated with obesity, and the abundances of Parabacteroides (Lieber et al, 2018;Zhao et al, 2018), Eubacterium xylanophilum group , GCA-900066575 , Lachnoclostridium (Zhao et al, 2017b), Lachnospiraceae UCG-006 (Kang et al, 2019), and Romboutsia (Zhao et al, 2018) were positively correlated with obesity. Bifidobacterium, a beneficial microbial species, producing lactic acid and acetic acid, can reduce intestinal pH and inhibit the growth of various detrimental bacteria to maintain intestinal health (Wang R. et al, 2018).…”

Section: Discussionsupporting

confidence: 93%

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Liu

et al. 2020

Front. Microbiol.

113

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The global prevalence of obesity is rising year by year, which has become a public health problem worldwide. In recent years, animal studies and clinical studies have shown that some lactic acid bacteria possess an anti-obesity effect. In our previous study, mixed lactobacilli (Lactobacillus plantarum KLDS1.0344 and Lactobacillus plantarum KLDS1.0386) exhibited anti-obesity effects in vivo by significantly reducing body weight gain, Lee's index and body fat rate; however, its underlying mechanisms of action remain unclear. Therefore, the present study aims to explore the possible mechanisms for the inhibitory effect of mixed lactobacilli on obesity. C57BL/6J mice were randomly divided into three groups including control group (Control), high fat diet group (HFD) and mixed lactobacilli group (MX), and fed daily for eight consecutive weeks. The results showed that mixed lactobacilli supplementation significantly improved blood lipid levels and liver function, and alleviated liver oxidative stress. Moreover, the mixed lactobacilli supplementation significantly inhibited lipid accumulation in the liver and regulated lipid metabolism in epididymal fat pads. Notably, the mixed lactobacilli treatment modulated the gut microbiota, resulting in a significant increase in acetic acid and butyric acid. Additionally, Spearman's correlation analysis found that several specific genera were significantly correlated with obesity-related indicators. These results indicated that the mixed lactobacilli supplementation could manipulate the gut microbiota and its metabolites (acetic acid and butyric acid), resulting in reduced liver lipid accumulation and improved lipid metabolism of adipose tissue, which inhibited obesity.

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Section: Discussionsupporting

confidence: 93%

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Liu

et al. 2020

Front. Microbiol.

113

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“…; Martinez et al . ). Intrapartum antibiotics can lead to increased abundance of Bacteroides and Enterobacteria and reduction of Bacteroidetes in the neonatal gut (Li et al .…”

Section: Introductionmentioning

confidence: 97%

“…; Martinez et al . ), as well as CS effectively bypassing normal microbial seeding by maternal vaginal and intestinal flora.…”

Section: Introductionmentioning

confidence: 99%

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Parturition and the perinatal period: can mode of delivery impact on the future health of the neonate?

Tribe

Taylor

Kelly

et al. 2018

The Journal of Physiology

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Caesarean section and instrumental delivery rates are increasing in many parts of the world for a range of cultural and medical reasons, with limited consideration as to how 'mode of delivery' may impact on childhood and long-term health. However, babies born particularly by pre-labour caesarean section appear to have a subtly different physiology from those born by normal vaginal delivery, with both acute and chronic complications such as respiratory and cardio-metabolic morbidities being apparent. It has been hypothesized that inherent mechanisms within the process of labour and vaginal delivery, far from being a passive mechanical process by which the fetus and placenta are expelled from the birth canal, may trigger certain protective developmental processes permissive for normal immunological and physiological development of the fetus postnatally. Traditionally the primary candidate mechanism has been the hormonal surges or stress response associated with labour and vaginal delivery, but there is increasing awareness that transfer of the maternal microbiome to the infant during parturition. Transgenerational transmission of disease traits through epigenetics are also likely to be important. Interventions such as probiotics, neonatal gut seeding and different approaches to clinical care have potential to influence parturition physiology and improve outcomes for infants.

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“…The sex of the offspring seems also to be of importance with female offspring being more affected. However, this evidence was gathered from animal models (Martinez et al, 2017) and more research is needed to ascertain if this also happens in humans.…”

Section: Introductionmentioning

confidence: 99%

Caesarean birth and adiposity parameters in 6‐ to 8‐year‐old urban Maya children from two cities of Yucatan, Mexico

Azcorra

Rodríguez

Banik

et al. 2019

American J Hum Biol

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Objectives: To analyze the association between birth mode and fat mass index (FMI= fat mass [kg]/height [m] 2 ), and z-score values of waist circumference (WCZ) and sum of triceps and subscapular skinfolds (SumSkfZ) in a sample of 256 6 to 8year-old urban Maya children from the cities of Merida and Motul in Yucatan, Mexico. waist circumference and skinfolds in children and height and weight in their mothers. Body composition was estimated in both generations through bioelectrical impedance analysis. Data on children's birth mode and birth weight were obtained from birth certificates. A pre-validated questionnaire for mothers was used regarding household living conditions. Multiple regression models were used to analyze the association between birth mode and adiposity parameters adjusting for the effect of place of residence, household crowding index, children's birth weight and maternal fat mass (FM). Separate regression models were run for boys and girls. Results: Caesarean-born children comprised 43% of the entire sample.Caesarean section (CS) was found to be associated with higher values of body adiposity in girls, but not in boys. Specifically, our models predicted that girls born by CS had an increased value of 0.817 kg/m 2 in FMI and showed higher standard deviations values for WCZ and SumskfZ (0.29 and 0.32 SD, respectively) than girls who were delivered vaginally. Discussion:Our results support the hypothesis that CS is associated with increased levels of adiposity in childhood, but only in girls.

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Increased weight gain by C-section: Functional significance of the primordial microbiome

Abstract: Mice born by C-section developed increased body weight and lacked microbiota developmental changes observed in control mice.

Cited by 78 publications

References 26 publications

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Probiotic Mixture of Lactobacillus plantarum Strains Improves Lipid Metabolism and Gut Microbiota Structure in High Fat Diet-Fed Mice

Parturition and the perinatal period: can mode of delivery impact on the future health of the neonate?

Caesarean birth and adiposity parameters in 6‐ to 8‐year‐old urban Maya children from two cities of Yucatan, Mexico

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