Impacto orçamentário da incorporação do GeneXpert MTB/RIF para o diagnóstico da tuberculose pulmonar na perspectiva do Sistema Único de Saúde, Brasil, 2013-2017

Pinto, Márcia; Steffen, Ricardo Ewbank; Entringer, Aline Piovezan; Costa, Ana Carolina Carioca da; Trajman, Anete

doi:10.1590/0102-311x00214515

Cited by 10 publications

(10 citation statements)

References 16 publications

(30 reference statements)

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“…Early deaths may indicate late diagnosis and this fact points out the need for faster examinations in order to detect the disease among the respiratory symptomatics (Brasil, 2011). In this sense, the incorporation of the rapid molecular test for TB using the GeneXpert MTB/RIF system in the Brazilian Unified Health System in the year 2013 can contribute to a faster diagnosis and a consequent change in this scenario (Pinto et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

Oliveira

Silveira

Beraldi-Magalhães

et al. 2019

International Journal of Infectious Diseases

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To know the profile of adults who died by tuberculosis as the main cause, the time interval between the diagnosis and death, associated comorbidities and vulnerabilities. Method: Observational study of secondary data regarding deaths by tuberculosis that occurred in the State of Paraná, Brazil, from 2008 to 2015. A linkage between the databases of mortality and tuberculosis notification system was conducted for data enrichment. Frequency tables, Exact Fisher test and Z test have identified statistical associations. Results: Linkage points out 12.1% (115/944) of under-reporting in the 944 deaths identified. Early deaths accounted for 74.6% (705/944). The male sex (75.8%) was associated with the early death group. Almost half of the deaths reported in notification system (414/829) had one or more vulnerabilities. Early death were associated with respiratory system diseases and symptoms (p = 0.0001) and mental and behavioral disorders (p = 0.0001). Conclusion: High number of early deaths due TB indicate the need to seek out the respiratory symptomatic and use faster diagnostic methods. Strategies for treatment adherence, adequate monitoring of comorbidities and multisectorial support may prevent early and late death. The presence of vulnerabilities indicates that efforts beyond the health sector are needed in order to eliminate tuberculosis as public health problem.

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Section: Discussionmentioning

confidence: 99%

Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

Oliveira

Silveira

Beraldi-Magalhães

et al. 2019

International Journal of Infectious Diseases

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“…The ABC value of the Xpert assay was higher than that of smear microscopy and the input was the component with the greatest impact. However, it should be noted that the Xpert system is subsidized in Brazil 22 . Efforts are being made to increase the coverage area of the Xpert system worldwide through subsidies to make it available in developing and underdeveloped countries, where health systems work under heavy economic constraints 22 , 23 .…”

Section: Discussionmentioning

confidence: 99%

“…The results described in this paper should alert Brazilian researchers to the need for the development and validation of a national molecular test. Although the Xpert system has high accuracy in the diagnosis of TB, national technological independence is necessary to ensure that cost is not a variable that hinders or even impedes the incorporation of a tool that is effective for the rapid and accurate diagnosis of TB 22 , 27 .…”

Section: Discussionmentioning

confidence: 99%

Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosis: average turnaround time

Figueredo

Miranda

Santos

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Rapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy and Xpert assay at a university hospital. Methods: The turnaround time and cost of the laboratory diagnosis of tuberculosis were calculated based on the mean cost and activity based costing (ABC). Results: The average turnaround time for smear microscopy was 16.6 hours while that for Xpert was 24.1 hours. The Xpert had a mean cost of USD 17.37 with an ABC of USD 10.86, while smear microscopy had a mean cost of USD 13.31 with an ABC of USD 6.01. The sensitivity of smear microscopy was 42.9% and its specificity was 99.1%, while the Xpert assay had a sensitivity of 100% and a specificity of 96.7%. Conclusions: The Xpert assay has high accuracy; however, the turnaround time and cost of smear microscopy were lower than those of Xpert.

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“…Страна перешла на диагностический алгоритм, по которому Xpert MTB/RIF должен использоваться в качестве начального диагностического теста во всех случаях подозрения на туберкулез, однако внедрение этой рекомендации в практику все еще в процессе. В настоящий момент в Бразилии диагностикой Xpert MTB/RIF покрывается 55% случаев туберкулеза [32]. Описательное аналитическое исследование бразильских ученых, посвященное изучению организационных аспектов выявления туберкулеза службами первичной медицинской помощи, включило оценку с использованием шкалы Ликерта 276 специалистов в области здравоохранения.…”

Section: результатыunclassified

Organization of tuberculosis detection in Russia and worldwide

Borodulina¹,

Суслин²

2018

Profil. med.

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Своевременное выявление туберкулеза является важнейшим мероприятием, препятствующим распространению туберкулезной инфекции среди населения, повышающим вероятность благоприятного исхода лечения больных. Проанализированы результаты зарубежных и отечественных оригинальных исследований по вопросам организации выявления туберкулеза за период 2010-2018 гг., представленные в базах медицинских и биологических публикаций PubMed и Elibrary, также изучены данные ежегодных докладов ВОЗ по туберкулезу. Представлены данные для стран-лидеров организации БРИКС, где сложилась напряженная обстановка по туберкулезу, и для эпидемиологически благополучных стран с низкой заболеваемостью (Великобритания, Австралия, США).

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Impacto orçamentário da incorporação do GeneXpert MTB/RIF para o diagnóstico da tuberculose pulmonar na perspectiva do Sistema Único de Saúde, Brasil, 2013-2017

Cited by 10 publications

References 16 publications

Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

Early death by tuberculosis as the underlying cause in a state of Southern Brazil: Profile, comorbidities and associated vulnerabilities

Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosis: average turnaround time

Organization of tuberculosis detection in Russia and worldwide

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