Organization of tuberculosis detection in Russia and worldwide

Borodulina, E.; Суслин, С А

doi:10.17116/profmed201821487

Profil. med.

2018

DOI: 10.17116/profmed201821487

|View full text |Cite

Organization of tuberculosis detection in Russia and worldwide

E. Borodulina¹,

С А Суслин²

Abstract: Своевременное выявление туберкулеза является важнейшим мероприятием, препятствующим распространению туберкулезной инфекции среди населения, повышающим вероятность благоприятного исхода лечения больных. Проанализированы результаты зарубежных и отечественных оригинальных исследований по вопросам организации выявления туберкулеза за период 2010-2018 гг., представленные в базах медицинских и биологических публикаций PubMed и Elibrary, также изучены данные ежегодных докладов ВОЗ по туберкулезу. Представлены данные … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

2021

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Evaluation of the efficiency of preventive examinations of the adult population, aimed at early tuberculosis diagnosis

Rubis¹,

Markelov

2021

Medical Journal of the Russian Federation

View full text Add to dashboard Cite

BACKGROUND: In Russia, compared with other countries, at least 65% of the population must undergo an annual fluorographic examination for early tuberculosis detection. AIM: This study aimed to assess the impact of mass fluorographic examinations of the adult population on the main epidemiological factors and indicators of prompt tuberculosis detection. MATERIALS AND METHODS: The morbidity and mortality from tuberculosis have been analyzed along with the efficiency of its detection during preventive examinations, the proportion of destructive forms of the disease, and the 1-year mortality rate in four federal districts from 2014 to 2019. RESULTS: For all districts, low efficiency of preventive examinations was registered (1 patient per 2,0005,000 people examined), as well as its strong correlation with morbidity and, in case of its absence, with the coverage of examinations. The change in morbidity and mortality rates over time was independent of the mass screening volume of the adult population. The relative risk indicators of increased morbidity and mortality with a decreased number of examinations were 0.4 and 0.3, respectively. The increased coverage of the population with examinations was not accompanied by an improved indicator of detection timeliness, namely a decreased incidence of destructive forms and 1-year mortality rate. The incidence of tuberculosis is determined by socioeconomic factors, which influence the level and living conditions of the population. CONCLUSIONS: This study established the low efficiency of mass fluorographic examinations of the population, lack of influence of coverage with examinations on the epidemiological situation, and the timeliness of tuberculosis detection.

show abstract

Evaluation of the efficiency of preventive examinations of the adult population, aimed at early tuberculosis diagnosis

Rubis¹,

Markelov

2021

Medical Journal of the Russian Federation

View full text Add to dashboard Cite

show abstract

New possibilities to diagnose pulmonary tuberculosis at a pulmonology inpatient department

Borodulina¹,

Бородулин²,

Инькова³

et al. 2019

Pulʹmonologiâ (Mosk.)

View full text Add to dashboard Cite

The aim of the study was to investigate new methods for pulmonary tuberculosis (TB) detection at a pulmonology inpatient department.Methods. Pulmonary TB cases (n = 49) newly diagnosed at a pulmonology department of a hospital were involved in the study; among them, 69.4% of patients were infected with human immunodeficiency virus (HIV). All patients were asked if he/she had previously contacted with other TB patients, and if he/she was diagnosed with TB previously. The patients were also about family history. Posteroanterior and lateral chest X-ray and laboratory analyses were performed in all patients. Mycobacteria tuberculosis (MBT) were searched using smear microscopy, GeneXpert MTB/RIF molecular method and culturing (BACTEC MGIT) of sputum and bronchoalveolar lavage fluid (BALF) obtained during bronchoscopy. Patients with positive results only were included in the analysis in order to investigate and to compare diagnostic value of the methods.Results. Questioning patients at admission was useful to diagnose TB in 4% of patients. Sputum smears were positive in 12 patients (27.3%). BALF was obtained in 18 patients (36.7%); among them, MBT was identified in 52 (5%). Molecular testing was positive in all 49 patients (100%); among them, BACTEC MGIT culturing yielded MBT in 48 patients (97.9%). In patients with negative sputum smears during the first 3 days after admission, GeneXpert required 10.4 ± 5.3 days.Conclusion. GeneXpert method was highly useful to diagnose TB and was comparable with BACTEC. Routine sputum and BALF smear microscopy was significantly less rapid and less sensitive method. The diagnostic accuracy could be increased with the use of molecular methods in patients with negative sputum smears obtained at a general hospital. Therefore, molecular methods could be used in patients highly suspected for TB.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Organization of tuberculosis detection in Russia and worldwide

Cited by 2 publications

References 37 publications

Evaluation of the efficiency of preventive examinations of the adult population, aimed at early tuberculosis diagnosis

Evaluation of the efficiency of preventive examinations of the adult population, aimed at early tuberculosis diagnosis

New possibilities to diagnose pulmonary tuberculosis at a pulmonology inpatient department

Contact Info

Product

Resources

About