Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan

Fujimoto, Naohiro; Kubo, Toshikazu; Hisaoka, Masanori; Udo, Kazuma; Yokomizo, Akira; Shibuya, Tomoyoshi; Wakeda, Hironobu; Nishihara, Kiyoaki; Moriya, Ryosuke; IWAKUMA, Keiko

doi:10.1111/iju.13469

Cited by 21 publications

(19 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study, 65 neurogenic tumors were located near the spine, accounting for 90.3% (65/72) of the tumors in the region. This is consistent with previous research . Fujimoto et al analyzed a total of 167 patients with primary retroperitoneal tumors during a 12‐year study and found that liposarcoma and schwannomas are the most common histological types of malignant and benign tumors…”

Section: Discussionsupporting

confidence: 88%

Evaluation of clinical application of multi‐slice computerized tomography in primary retroperitoneal tumors

Feng

Zhang

Luo

2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Background To accurately identify primary retroperitoneal tumors by multi‐slice spiral CT (MSCT) for better treatment. Materials and Methods The common types of 380 cases of primary retroperitoneal tumor, lesion sites, and MSCT features were compared with pathological results. Fisher's or chi‐square test approaches have been applied in this study. Results Multi‐slice computerized tomography multi‐directional reconstruction has a high accuracy for primary retroperitoneal tumors (95.7%). Seventy‐three liposarcoma cases were located in peri‐renal space, accounting for 76.8% (13/95) of the tumors in this region. Meanwhile, 65 cases of neurogenic tumors were located in the paravertebral column, accounting for 90.3% (65/72) of the tumors in this region. MSCT examination could effectively distinguish benign from malignant of primary retroperitoneal tumor (sensitivity = 87.2%, specificity = 82.7%, accuracy rate = 84.5%). Malignant tumors showed more irregularity shape than benign tumor (χ2 = 20.468, P < .001). 82.7% (191/231) of the malignant tumors showed adhesion or even invasion of surrounding tissues and organs (χ2 = 23.262, P < .001). Fat density of the lipoma is uniform, and lesion is not enhanced. Liposarcoma can be seen in varying proportions of fat and soft tissue density. Conclusion The accuracy of MSCT scan for retroperitoneal tumors is high. Meanwhile, the coincidence rate of qualitative diagnosis before operation and/or before biopsy is also high.

show abstract

Section: Discussionsupporting

confidence: 88%

Evaluation of clinical application of multi‐slice computerized tomography in primary retroperitoneal tumors

Feng

Zhang

Luo

2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…Considering malignancy cannot be excluded preoperatively and even intraoperative frozen section cannot provide accurate pathology diagnosis, it is recommended that the management of retroperitoneal schwannomas is complete surgical excision with negative soft tissue margins. [ 21 ] However, controversies still exist about whether excision of adjacent tissue and viscera is necessary or not. Some authors suggested that simple enucleation or partial excision without removal of adjacent organs was sufficient because of the benign nature for most cases and loss of adjacent organs may influence the prognosis.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of retroperitoneal schwannoma complicated with severe hydronephrosis

et al. 2018

View full text Add to dashboard Cite

Rationale:Schwannomas are usually benign tumors arising from well-differentiated schwann cells, which rarely occur in the retroperitoneal space. The lack of specific signs and radiologic imaging characteristics makes preoperative diagnosis rather difficult. Most retroperitoneal schwannomas are benign and the primary treatment choice for retroperitoneal schwannomas is surgical excision, however, the involvement of the urinary system is scarcely reported.Patient concerns:A 34-year-old woman presented with progressive left abdominal pain and rebound abdominal mass at the left lower quadrant for 1 month. Radiological imaging suggested capsulated solid mass with cystic and necrotic areas in the retroperitoneum accompanied by severe left kidney hydronephrosis and preoperative biopsy result was inconclusive.Diagnoses:We believe this is a rare case of retroperitoneal schwannoma complicated with severe hydronephrosis.Interventions:After preparation, the patient underwent laparoscopy exploration and converted to open surgical exploration. The patient accepted complete surgical excision of the retroperitoneal tumor and left kidney. Postoperative pathology diagnosis of the mass was proven to be benign retroperitoneal schwannoma.Outcomes:Postoperative course of the patient was uneventful and the left abdominal pain was greatly improved. After 12-month follow up, no evidence of recurrence or any other complication including renal failure was observed.Lessons:Preoperative imaging and preoperative ultrasound-guided biopsy are helpful to make accurate diagnosis. The final diagnosis is based on postoperative histological and immunohistochemical findings. The primary treatment option is complete surgical resection of the retroperitoneal schwannoma and the involved upper urinary system when severe hydronephrosis occured. Local recurrence and overall survival are closely correlated with negative resection margins and pathology types.

show abstract

“…2 As mentioned by Fujimoto et al, one of the characteristics of this article is that not only STS, but also benign tumors, were analyzed and discussed. 3 There are just a few reports regarding Asian patients with primary retroperitoneal tumors. The present study showed that approximately 40% of all patients had benign tumors, and the most common benign retroperitoneal tumor was schwannoma.…”

Section: Editorial Commentmentioning

confidence: 99%

“…2 The present study by Fujimoto et al is valuable in that it describes intimate data on the demographics, treatments and prognoses of retroperitoneal tumors, using a multi-institutional cohort of 167 Japanese patients. 3 The study included both intermediate/ malignant and benign tumors, which might compromise the purity of the study cohort, but could reflect the real-world situation instead.…”

mentioning

confidence: 99%

Editorial Comment from Dr Taguchi to Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan

Taguchi

2017

Int J of Urology

View full text Add to dashboard Cite

References1 Ducimeti ere F, Lurkin A, Ranch ere-Vince D et al. Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing. PLoS ONE 2011; 6: e20294. 2 Liles JS, Tzeng CW, Short JJ, Kulesza P, Heslin MJ. Retroperitoneal and intra-abdominal sarcoma. Curr. Probl. Surg. 2009; 46: 445-503. 3 Lewis JJ, Leung D, Woodruff JM, Brennan MF. Retroperitoneal soft-tissue sarcoma: analysis of 500 patients treated and followed at a single institution. Ann. Surg. 1998; 228: 355-65. 4 Nathan H, Raut CP, Thornton K et al. Predictors of survival after resection of retroperitoneal sarcoma: a population-based analysis and critical appraisal of the AJCC staging system. Ann. Surg. 2009; 250: 970-6. 5 Bonvalot S, Rivoire M, Castaing M et al. Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control. J. Clin. Oncol. 2009; 27: 31-7. 6 Lehnert T, Cardona S, Hinz U et al. Primary and locally recurrent retroperitoneal soft-tissue sarcoma: local control and survival. Eur. J. Surg. Oncol. 2009; 35: 986-93. 7 Anaya DA, Lahat G, Wang X et al. Postoperative nomogram for survival of patients with retroperitoneal sarcoma treated with curative intent. Ann. Oncol. 2010; 21: 397-402. 8 Strauss DC, Hayes AJ, Thway K, Moskovic EC, Fisher C, Thomas JM. Surgical management of primary retroperitoneal sarcoma. Br. J. Surg. 2010; 97: 698-706. 9 Gronchi A, Miceli R, Shurell E et al. Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets. J. Clin. Oncol. 2013; 31: 1649-55. 10 Toulmonde M, Bonvalot S, Meeus P et al. Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group. Ann. Oncol. 2014; 25: 735-42. 11 Smith HG, Panchalingam D, Hannay JA et al. Outcome following resection of retroperitoneal sarcoma. Br. J. Surg. 2015; 102: 1698-709. 12 Gronchi A, Miceli R, Allard MA et al. Personalizing the approach to retroperitoneal soft tissue sarcoma: histology-specific patterns of failure and postrelapse outcome after primary extended resection. Ann. Surg. Oncol. 2015; 22: 1447-54. 13 Tan MC, Yoon SS. Surgical management of retroperitoneal and pelvic sarcomas. J. Surg. Oncol. 2015; 111: 553-61. 14 Abdelfatah E, Guzzetta AA, Nagarajan N et al. Long-term outcomes in treatment of retroperitoneal sarcomas: a 15 year single-institution evaluation of prognostic features. J. Surg. Oncol. 2016; 114: 56-64. 15 Stahl JM, Corso CD, Park HS et al. The effect of microscopic margin status on survival in adult retroperitoneal soft tissue sarcomas. Eur. J. Surg. Oncol. 2017; 43: 168-74. 16 Krane A, Crago AM. The importance of surgical margins in retroperitoneal sarcoma. J. Surg. Oncol. 2016; 113: 270-6. 17 Chou YS, Liu CY, Chang YH et al. Prognostic factors of primary resected retroperitoneal soft tissue sarcoma:...

show abstract

Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan

Cited by 21 publications

References 23 publications

Evaluation of clinical application of multi‐slice computerized tomography in primary retroperitoneal tumors

Evaluation of clinical application of multi‐slice computerized tomography in primary retroperitoneal tumors

Surgical management of retroperitoneal schwannoma complicated with severe hydronephrosis

Editorial Comment from Dr Taguchi to Demographics, management and treatment outcomes of benign and malignant retroperitoneal tumors in Japan

Contact Info

Product

Resources

About