The Effects of Selenium Supplementation on Glucose Metabolism and Lipid Profiles Among Patients with Metabolic Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of selenium administration on glucose metabolism and lipid profiles among patients with diseases related to metabolic syndrome (MetS). We searched the following databases up to May 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (MDs) with 95% confidence intervals (95% CI). Five studies were included in the meta-analyses. The results showed that selenium supplementation significantly reduced insulin levels (SMD -0.42; 95% CI, -0.83 to -0.01) and increased quantitative insulin sensitivity check index (QUICKI) (SMD 0.83; 95% CI, 0.58 to 1.09). Selenium supplementation had no beneficial effects on other glucose homeostasis parameters, such as fasting plasma glucose (FPG) (SMD -0.29; 95% CI, -0.73 to 0.15), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD -0.80; 95% CI, -1.58 to -0.03), and lipid profiles, such as triglycerides (SMD -0.42; 95% CI, -0.83 to -0.01), VLDL- (SMD -0.42; 95% CI, -0.83 to -0.01), total- (SMD -0.42; 95% CI, -0.83 to -0.01), LDL- (SMD 0.02; 95% CI, -0.20 to 0.24), and HDL-cholesterol (SMD 0.16; 95% CI, -0.06 to -0.38). Overall, this meta-analysis showed that selenium administration may lead to an improvement in insulin and QUICKI, but did not affect FPG, HOMA-IR, and lipid profiles.

Effectiveness and safety of selenium supplementation for type 2 diabetes mellitus in adults: a systematic review of randomised controlled trials

“…By contrast, Tabrizi et al (6) noted the positive effect of Se on QUICKI outcome, and no impact on FPG (6) . As a result of these and other abovementioned limitations, our conclusions differ.…”

“…No similar protocols of systematic reviews had been published at the stage of commencing this work. However, during the completion of our review, another systematic review by Tabrizi et al (6) concerning Se intervention was identified. Compared to our systematic review, numerous limitations were identified.…”

“…Although inconsistent data suggest that Se influences the course of T2DM, the direction of the effect remains unclear. More recently, Tabrizi et al (6) concluded that Se supplementation reduced insulin concentrations and increased the quantitative insulin sensitivity check index (QUICKI) compared to placebo, with no beneficial effects of the intervention on the other outcomes of interest.…”

Effect of Selenium Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis

“…Another clinical trial with high-selenium yeast indicated a modestly beneficial effect the lipid profile of the subjects with low serum levels of selenium [16]. Recently Tabrizi et al conducted a systematic review and meta-analysis on patients with metabolic diseases and the results showed positive effects of selenium supplementation on lipid profiles [17]. However, to the best of our knowledge, no comprehensive meta-analysis has been carried out on the effect of selenium supplement on lipid profile in all type of diseases.…”

Selenium supplementation lowers insulin resistance and markers of cardio-metabolic risk in patients with congestive heart failure: a randomised, double-blind, placebo-controlled trial

“…It has been suggested that Se may be involved in the deconditioning of skeletal and cardiac muscles and in CHF symptoms including fatigue and low exercise tolerance, rather than in ventricular dysfunction (14,15) . Some studies have reported the beneficial effects of Se supplementation on glycaemic control and biomarkers of inflammation and oxidative stress in patients with T2DM and CHD (16)(17)(18) . This evidence may suggest the importance of Se in patients with CHF.…”