Drug‐induced immune hemolytic anemia associated with anti‐vancomycin complicated by a paraben antibody

Gniadek, Thomas J.; Arndt, Patricia A.; Leger, Regina M.; Zydowicz, Daniel; Cheng, Edward Y.; Zantek, Nicole D.

doi:10.1111/trf.14362

Cited by 12 publications

(13 citation statements)

References 22 publications

(41 reference statements)

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“…MIC values for vancomycin against MRSA USA300 Los Angeles County clone (LAC) range from 0.71 to 0.89 μgmL −1 [41, 42]. However, the reported clinical efficacy is only 35-57% [43, 44] with a high risk of drug-induced hematologic disorders [45, 46]. In vitro cytotoxicity is determined as the rate of hemolysis on human erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes

Andreev

Martynowycz

Huang

et al. 2018

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Hydrophobic interactions govern specificity for natural antimicrobial peptides. No such relationship has been established for synthetic peptoids that mimic antimicrobial peptides. Peptoid macrocycles synthesized with five different aromatic groups are investigated by minimum inhibitory and hemolytic concentration assays, epifluorescence microscopy, atomic force microscopy, and X-ray reflectivity. Peptoid hydrophobicity is determined using high performance liquid chromatography. Disruption of bacterial but not eukaryotic lipid membranes is demonstrated on the solid supported lipid bilayers and Langmuir monolayers. X-ray reflectivity studies demonstrate that intercalation of peptoids with zwitterionic or negatively charged lipid membranes is found to be regulated by hydrophobicity. Critical levels of peptoid selectivity are demonstrated and found to be modulated by their hydrophobic groups. It is suggested that peptoids may follow different optimization schemes as compared to their natural analogues.

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Section: Introductionmentioning

confidence: 99%

Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes

Andreev

Martynowycz

Huang

et al. 2018

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…The three major etiologies of acquired aplastic anemia include direct toxicity, metabolite-driven toxicity, and immune-mediated mechanisms [9]. For instance, a 2018 case report by Gniadek and a 2007 clinical report by Drygalski describe a mechanism of immune thrombocytopenia involving vancomycin dependent platelet reactive antibodies [6,10]. Pancytopenia has also been described to be more likely with both slow and fast rates of infusion as well as lengthy duration of vancomycin infusion [1,4].…”

Section: Discussionmentioning

confidence: 99%

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity

Cho

Avera

Iyamu

2019

Cureus

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This case involves a 62-year-old male with a prior history of epidural abscess and L1-L2 osteodiscitis who was admitted because of low back pain. The patient was previously treated for methicillin-susceptible Staphylococcus aureus (MSSA) discitis in the L1/L2 vertebral region with intravenous (IV) nafcillin through a peripherally inserted central catheter (PICC). However, he returned after four months with recurrent low back pain along with chills and fever. He was admitted for severe sepsis related to the L1-L2 region osteomyelitis and discitis. The Infectious Disease department initially started the patient on IV vancomycin and cefepime; however, routine labs on the second day of IV antibiotics showed concern for pancytopenia with white blood cell count (WBC) decreased to 2.5 thou/mm 3 , Hgb to 6.2 g/dL, Hct to 20.8%, and platelets to 82 thou/mm 3 from baseline values of WBC 3.9 thou/mm 3 , Hgb 8.3 g/dL, Hct 28%, and platelets 126 thou/mm 3 . Due to concern for pancytopenia in the setting of severe sepsis, extensive hematologic workup was pursued to evaluate for disseminated intravascular coagulation (DIC) and bone marrow suppression. The patient also had a positive fecal occult blood test, so the Gastroenterology department was consulted for esophagogastroduodenoscopy (EGD) and colonoscopy. Furthermore, despite appropriate outpatient treatment for MSSA osteodiscitis, the patient was bacteremic with Staphylococcus aureus. Hence, the Cardiology department was consulted to rule out cardiac valvular vegetation. This case presents a unique case of pancytopenia involving elements of drug-induced aplastic anemia as well as DIC-related sepsis. The agranulocytosis may have been a consequence of drug reaction to IV vancomycin. The anemia and thrombocytopenia may have been caused by DIC. Repeat computed tomography (CT) guided spinal aspiration confirmed pan-sensitive Staphylococcus aureus infection of the L1/L2 vertebral region. Treatment was reverted to nafcillin monotherapy and fortunately his hematologic function normalized, avoiding the need for advanced treatments such as intravenous immunoglobulin infusion therapy (IVIG) or high dose steroids.

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“…Preservatives Na-azide and esters of parabens, and antibiotics are added to commercially available LISS(C-LISS)® to prevent microbial growth [24][25][26]. Th e additives used for the storage, preservation, and coloring of blood bank reagents can be a source of false positive agglutination reactions [27].…”

Section: The Topic Position In Scientific/professional Publicmentioning

confidence: 99%

The role of the Kidd-antibodies in posttransfusion reactions

Nikolić¹,

Čolak²,

Kadija³

et al. 2019

Hosp Pharm Int Multi J

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Topic: The Kidd blood group (Jk) was discovered in 1951 and according to International Society for blood transfusion (ISBT) the Kidd (Jk) blood group is registered under the number 009. Antigens of the Kidd system are detected only on RBCs and kidney. Incompatibile transfusion in Jk blood group can provoke sensitization and appearance of anti-Jka or anti-Jkb antibodies. Jk antibodies are common cause of delayed hemolytic transfusion reactions (DHTRs). Although Kidd antibodies can lead to acute reactions, kidney damage and hemoglobinuria are very rare. More important is Kidd-antibody ability for delayed hemolytic reactions. The aim is to underline Jka antibodies laboratory characteristics, their role in delayed posttransfusion reactions and possible complications of blood transfusions. The topic position in scientifi c/professional public: Kidd-antibodies, usually, destroy transfused red cells after a variable period of between 7 and 21 days. DHTR is the result of anti-Jka antibodies tendency to fall rapidly to undetectable levels even after incompatible transfusion. Anti-Jka has been reported as reason for kidney transplant rejection. There were examples of anti-Jka that react only when preservatives such as p-hydroxybenzoic acid (parabens), Na-azide or related compounds, antibiotics are present in the reaction mixture. Also, patient's therapy with antibiotics and monoclonal antibodies could cause false positive RBC antibody. Further action needed for better topic covering in future: Except in life threatening condition, reduction of allogenic blood transfusion is recommended. Increase the number of autologous transfusions in all cases when the patient's clinical condition allows. Antigen-free RBC ie universal RBC would be the best choice for transfusion. It is essential to perform extended erythrocyte phenotyping prior to initiation of monoclonal antibodies therapy. As a minimum blood typing for Rh, K, Jka,Jkb, Fya, Fyb and Ss antigens should be done for every patient who is planned to be treated with monoclonal antibodies.Overcoming this problem is very important for patients who are transfusion-dependent or candidates for monoclonal antibody therapy, or candidates for kidney transplantation.

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Drug‐induced immune hemolytic anemia associated with anti‐vancomycin complicated by a paraben antibody

Cited by 12 publications

References 22 publications

Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes

Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes

Pancytopenia as a Consequence of Sepsis and Intravenous Antibiotic Drug Toxicity

The role of the Kidd-antibodies in posttransfusion reactions

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