Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development

Sugii, Hideki; Grimaldi, Alexandre; Li, Jingyuan; Parada, Carolina; Vu-Ho, Thach; Feng, Jifan; Jing, Junjun; Yuan, Yuan; Guo, Yuxing; Maeda, Hidefumi; Chai, Yang

doi:10.1242/dev.155176

Cited by 28 publications

(36 citation statements)

References 35 publications

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“…5 B'', C''). These observations reinforce the notion that cephalic myogenic precursors require Dlx5/6dependent morphogenetic instructions from NCCs for proper jaw muscle patterning and differentiation 38 .…”

Section: Dlx5/6 Expression In Neural Crest Cells Is Required For Propsupporting

confidence: 85%

Probing the origin of matching functional jaws: roles ofDlx5/6in cranial neural crest cells

Shimizu

Narboux-Nême

Gitton

et al. 2018

Preprint

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SUMMARYGnathostome jaws derive from the first pharyngeal arch (PA1), a complex structure constituted by Neural Crest Cells (NCCs), mesodermal, ectodermal and endodermal cells. Here, to determine the regionalized morphogenetic impact of Dlx5/6 expression, we specifically target their inactivation or overexpression to NCCs. NCC-specific Dlx5/6 inactivation (NCCΔDlx5/6) generates severely hypomorphic lower jaws that present typical maxillary traits. Therefore, differently from the symmetric jaws obtained after constitutive Dlx5/6 inactivation, NCCΔDlx5/6 embryos present a strikingly asymmetric mouth. Reciprocally, forced Dlx5 expression in maxillary NCCs provokes the appearance of distinct mandibular characters in the upper jaw. We conclude that: 1) Dlx5/6 activation in NCCs invariably determines lower jaw identity; 2) the morphogenetic processes that generate functional matching jaws depend on the harmonization of Dlx5/6 expression in NCCs and in distinct ectodermal territories. The co-evolution of synergistic opposing jaws requires the coordination of distinct regulatory pathways involving the same transcription factors in distant embryonic territories.

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Section: Dlx5/6 Expression In Neural Crest Cells Is Required For Propsupporting

confidence: 85%

Probing the origin of matching functional jaws: roles ofDlx5/6in cranial neural crest cells

Shimizu

Narboux-Nême

Gitton

et al. 2018

Preprint

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“…However, other muscles, including the levator veli palatine, palatopharyngeal, and palatoglossal, are innervated by branches of the vagus (CNX) nerve, indicative of a more caudal embryonic origin (Edgeworth, ; Michailovici et al, ). Tracing studies using Dlx5 as a marker found that NCr cells from BA4 move into the developing soft palatal shelves and form a scaffolding necessary for the morphogenesis of their accompanying myoblasts (Grimaldi, Parada, & Chai, ; Sugii et al, ).…”

Section: Partnering Myoblasts With Neural Crest Cellsmentioning

confidence: 99%

Neural crest and the patterning of vertebrate craniofacial muscles

Ziermann

Diogo

Noden

2018

Genesis

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Patterning of craniofacial muscles overtly begins with the activation of lineage-specific markers at precise, evolutionarily conserved locations within prechordal, lateral, and both unsegmented and somitic paraxial mesoderm populations. Although these initial programming events occur without influence of neural crest cells, the subsequent movements and differentiation stages of most head muscles are neural crest-dependent. Incorporating both descriptive and experimental studies, this review examines each stage of myogenesis up through the formation of attachments to their skeletal partners. We present the similarities among developing muscle groups, including comparisons with trunk myogenesis, but emphasize the morphogenetic processes that are unique to each group and sometimes subsets of muscles within a group. These groups include branchial (pharyngeal) arches, which encompass both those with clear homologues in all vertebrate classes and those unique to one, for example, mammalian facial muscles, and also extraocular, laryngeal, tongue, and neck muscles. The presence of several distinct processes underlying neural crest:myoblast/myocyte interactions and behaviors is not surprising, given the wide range of both quantitative and qualitative variations in craniofacial muscle organization achieved during vertebrate evolution.

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“…In vitro, BMP and WNT inhibit the proliferation and differentiation of myoblasts, which can be rescued by the addition of noggin, gremlin, or FRZB (Tzahor et al 2003). Simultaneously, Dlx5 is expressed by SCX-positive precursors (Sugii et al 2017). Dlx5 knockout mouse embryos in this study show reduced fibroblast growth factor 10 (FGF10) expression and impaired branchiomeric muscle formation.…”

Section: Molecular Regulation Of Branchiomeric Muscle Developmentmentioning

confidence: 66%

“…The orofacial muscles include the muscles of mastication, the muscles of cheeks and lips, the soft palate muscles, the suprahyoid muscles, and the tongue muscles (Le Reverend et al 2014). These muscles develop from the mesoderm of the pharyngeal arches and the occipital somites (Sugii et al 2017;Chang and Kioussi 2018). The muscles of the trunk and limbs develop from the thoracic and lumbal somites, respectively (Chang and Kioussi 2018).…”

Section: Introductionmentioning

confidence: 99%

Orofacial Muscles: Embryonic Development and Regeneration after Injury

et al. 2019

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Orofacial congenital defects such as cleft lip and/or palate are associated with impaired muscle regeneration and fibrosis after surgery. Also, other orofacial reconstructions or trauma may end up in defective muscle regeneration and fibrosis. The aim of this review is to discuss current knowledge on the development and regeneration of orofacial muscles in comparison to trunk and limb muscles. The orofacial muscles include the tongue muscles and the branchiomeric muscles in the lower face. Their main functions are chewing, swallowing, and speech. All orofacial muscles originate from the mesoderm of the pharyngeal arches under the control of cranial neural crest cells. Research in vertebrate models indicates that the molecular regulation of orofacial muscle development is different from that of trunk and limb muscles. In addition, the regenerative ability of orofacial muscles is lower, and they develop more fibrosis than other skeletal muscles. Therefore, specific approaches need to be developed to stimulate orofacial muscle regeneration. Regeneration may be stimulated by growth factors such fibroblast growth factors and hepatocyte growth factor, while fibrosis may be reduced by targeting the transforming growth factor β1 (TGFβ1)/myofibroblast axis. New approaches that combine these 2 aspects will improve the surgical treatment of orofacial muscle defects.

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Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development

Cited by 28 publications

References 35 publications

Probing the origin of matching functional jaws: roles ofDlx5/6in cranial neural crest cells

Probing the origin of matching functional jaws: roles ofDlx5/6in cranial neural crest cells

Neural crest and the patterning of vertebrate craniofacial muscles

Orofacial Muscles: Embryonic Development and Regeneration after Injury

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