Quality of Life in Elderly Bladder Cancer Patients Following a Cystectomy

Lavdaniti, Maria; Zyga, Sofia

doi:10.1007/978-3-319-57348-9_28

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Bladder cancer has a higher progression and recurrence rates than other tumors in the urinary system ( Robertson et al, 2020 ), which increases not only the physical and mental suffering but also the economic burden of patients ( Lavdaniti and Zyga, 2017 ). ITH is a fundamental property of bladder cancer and is a major obstacle to improving patient outcomes, in case, it is particularly important to investigate the heterogeneity of bladder cancer cell lineage.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Lineage Diversity in Bladder Cancer Revealed by Single-Cell Sequencing

Peng

et al. 2022

Front. Genet.

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Bladder cancer is the most common malignant tumor of the urinary system. We investigated the clinical implications of cell lineages in bladder cancer by integrating single-cell and bulk transcriptome data. By investigating the single-cell transcriptional profiles of 12,424 cells from normal bladder, eleven cell types and five types of epithelial sub-population were identified. Based on the signature of cell types identified in single-cell profiles, deconvolution analysis was employed to estimate cell types and epithelial lineages in the bulk RNA sequencing bladder cancer cohort. Cancer subtypes with clinical implications were further identified based on the heterogeneity of the epithelial lineage across patients. This study suggests that the EMT-like subtype is robustly correlated with poor prognosis and the umbrella subtype is a positive factor for the patient survival. Our research has a high potential for accurate prognostic and therapeutic stratification of bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Lineage Diversity in Bladder Cancer Revealed by Single-Cell Sequencing

Peng

et al. 2022

Front. Genet.

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“…Therefore, it is of great significance to actively implement effective nursing intervention while providing necessary surgical treatment to patients with bladder cancer. These measures are conducive to disease recovery and can help improve patients' negative emotions, sleep, and quality of life (7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

Effect of individualized psychological intervention on negative emotion and sleep quality of patients after bladder cancer surgery: a randomized controlled trial

Zhang¹,

Han²,

Zhang³

et al. 2021

Transl Androl Urol

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Elderly and bladder cancer: The role of radical cystectomy and orthotopic urinary diversion

Bizzarri,

Scarciglia,

Russo

et al. 2024

Urologia

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The incidence of bladder cancer (BC) depends on advancing age and other risk factors, significantly impacting on surgical, functional and oncological outcomes. Radical cystectomy (RC) with urinary diversion is the gold standard therapy for muscle invasive bladder cancer; however, it remains a complex surgery and requires careful analysis of risk factors in order to potentially decrease post-surgical complication rates. Age in surgery is a limiting factor that can modify surgical and oncological outcomes, and is correlated with a high rate of post-dimssion hospital readmissions. The reconstruction of the bladder with the intestine represents a crucial point of radical cystectomy and the urinary derivation (UD) is at the center of many debates. A non-continent UD seems to be the best choice in elderly patients (>75 years old), while orthotopic neobladder (ON) is poorly practiced. We reviewed the literature to identify studies reporting outcomes, complications, patient- selection criteria, and quality-of-life data on elderly patients, who underwent ON following radical cystectomy. Reviewing the literature there is no clear evidence on the use of age as an exclusion criterion. Certainly, the elderly patient with multiple comorbidities is not eligible for ON, preferring other UD or rescue therapies. A careful preoperative selection of elderly patients could greatly improve clinical, surgical and oncological outcomes, giving the chance to selected patients to receive an ON.

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Quality of Life in Elderly Bladder Cancer Patients Following a Cystectomy

Abstract: All types of treatment have a number of advantages and disadvantages, the details of which should be explained to elderly patients thoroughly. This calls for comprehensive counseling sessions during which the patient and health professional discuss all relevant considerations.

Cited by 4 publications

References 5 publications

Prognostic Significance of Lineage Diversity in Bladder Cancer Revealed by Single-Cell Sequencing

Prognostic Significance of Lineage Diversity in Bladder Cancer Revealed by Single-Cell Sequencing

Effect of individualized psychological intervention on negative emotion and sleep quality of patients after bladder cancer surgery: a randomized controlled trial

Elderly and bladder cancer: The role of radical cystectomy and orthotopic urinary diversion

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