Clinical manifestations of Behçet’s disease depending on sex and age: results from Japanese nationwide registration

Ishido, Takehito; Horita, Nobuyuki; Takeuchi, Masaki; Kawagoe, Tatsukata; Shibuya, Etsuko; Yamane, Takahiro; Hayashi, Takahiko; Meguro, Akira; Ishido, Mizuho; Minegishi, Kazuhiro; Yoshimi, Ryusuke; Kirino, Yohei; Kato, Shingo; Arimoto, Jun; Ishigatsubo, Yoshiaki; Takeno, Mitsuhiro; Kurosawa, Michiko; Kaneko, Takeshi; Mizuki, Nobuhisa

doi:10.1093/rheumatology/kex285

Cited by 63 publications

(44 citation statements)

References 28 publications

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“…A smoking history was present only in one 46-year-old male patient with deep vein thrombosis, indicating that there was no association of thrombosis with smoking in these patients. A Japanese and a further Turkish group have similarly reported that genital ulcers were more frequent among female patients (OR 0.29, 95% CI [0.25-0.32], p<0.001 and male 971/1138 [85.6%] vs. female 995/1095 [91.0%], p<0.001), 24,25 while this was not observed in our data. Ocular manifestations showed male predominance in both data sets; on the other hand, only the Turkish group reported male predominance of papulopustular eruptions, thrombophlebitis, and neurologic, pulmonary and vascular involvement.…”

Section: Discussioncontrasting

confidence: 53%

Associations of Mitochondrial Deoxyribonucleic Acid Polymorphisms With Behçet's Disease in the Korean Population

Kwon

Yoo

et al. 2019

Arch Rheumatol

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Objectives: This study aims to examine the possible associations of mitochondrial single nucleotide polymorphisms (SNPs) and Behçet's disease (BD) in a larger patient group. Patients and methods: Whole blood or buffy coat was collected from 98 BD patients (31 males, 67 females; mean age 48±2.8 years; range 20 to 60 years) from four university hospitals located in the Chung-Cheong district of the Republic of Korea, and 196 age-and sex-matched healthy controls (HCs) (62 males, 134 females; mean age 46.91±12.90 years; range 20 to 68 years) from Konyang University Hospital. Twenty targeted mitochondrial deoxyribonucleic acids (DNAs) were genotyped and compared using the revised Cambridge Reference Sequence. Chi square and Fisher's exact tests were used to analyze association of mitochondrial DNA SNPs with BD susceptibility and its clinical characteristics.

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Section: Discussioncontrasting

confidence: 53%

Associations of Mitochondrial Deoxyribonucleic Acid Polymorphisms With Behçet's Disease in the Korean Population

Kwon

Yoo

et al. 2019

Arch Rheumatol

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“…The disease usually affects individuals aged between 20 and 40 years. Studies in Asia-Pacific countries have reported that 18-66% of patients have uveitis (Table 3) [47][48][49][50][51][52][53][54][55][56][57][58][59]. Interestingly, a decreasing trend in the prevalence of uveitis in Behcet's disease has been noticed in China, Japan, and Korea.…”

Section: Behcet's Diseasementioning

confidence: 99%

Noninfectious uveitis in the Asia–Pacific region

Hsu

Huang

Tao

et al. 2018

Eye

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Uveitis is a sight-threatening disease. Up to 35% of patients may have impaired vision. Inflammation of the uvea tissue has more than 60 etiologies. Previous reports have shown that 20-40% of uveitis cases were noninfectious. Some of them may be associated with systemic rheumatological and autoimmune diseases but some may affect the eyes only. The epidemiology and clinical situations of some specific uveitis entities vary worldwide because they are influenced by genetic, ethnic, environmental, and socioeconomic factors. The Asia-Pacific region comprises more than 30 countries. Epidemiology and patterns of uveitis vary greatly in this region. However, some uveitis entities, such as Behcet's disease, sarcoidosis, and Vogt-Koyanagi-Harada disease, are more common in this region. Many studies on the epidemiology, risk factors, and immune pathogenesis of this disease have been conducted. In this article, we review the epidemiology of noninfectious uveitis and special situations of these three uveitis entities in the Asia-Pacific region.

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“…The average age of onset peaks at the second to third decades, so it generally is regarded as a disease of young adults. The clinical features and course of the disease are closely associated with gender and age [3,4]. Despite affecting almost all organs, major organ involvement rarely coexists with each other.…”

Section: Introductionmentioning

confidence: 99%

Phenotype heterogeneity in Late-onset Behçet’s syndrome: A cohort from a referral center in China

Zou¹,

Luo²,

Luo³

et al. 2020

Preprint

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Objectives To elaluate the demographic, clinical and major organ involvement of patients with late-onset Behçet’s syndrome (BS) in a tertiary centre in China.Methods It was a cross-sectional study of consecutive BS patients in Huadong Hospital of Fudan University between September 2012 and January 2020, we identified 152 late-onset BS patients diagnosed after age of 40 years. We compared clinical variables between patients with disease onset age before and after 40 years. The relative risks (RRs) of clinical variables were calculated between two age groups. Moreover, a hierarchical cluster analysis was conducted according to twenty-nine variables to determine homogeneous subgroups of patients.Results Late-onset BS patients had a higher incidence of intestinal ulcer (late-onset : early-onset, RR 1.47), but a lower incidence of ocular involvement (RR 0.54) and folliculitis (RR 0.46). Female was associated with genital ulcer, erythema nodosum, and arthritis. Four clusters (C1–C4) were formed. C1 (n = 71) the largest cluster, defined as mucocutaneous group. C2 (n = 20), the arthritis group, C3 (n = 39), the gastrointestinal type, all patients presented with intestinal lesion, and five cases with esophageal ulcer. In C4 (n = 22), showing a mixture of uveitis and vascular group, fifteen patients presented with uveitis and eight had vascular lesion, and one cases had central nervous system lesions.Conclusion This is the first cluster analysis to be carried out in a cohort of late-onset BS patients in China. The significantly lower prevalence of folliculitis in late onset BS and the overall milder disease course suggest that testosterone status may influence disease activity.

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Clinical manifestations of Behçet’s disease depending on sex and age: results from Japanese nationwide registration

Abstract: We showed that clinical phenotype in early phase of BD was different depending on onset age and sex.

Cited by 63 publications

References 28 publications

Associations of Mitochondrial Deoxyribonucleic Acid Polymorphisms With Behçet's Disease in the Korean Population

Associations of Mitochondrial Deoxyribonucleic Acid Polymorphisms With Behçet's Disease in the Korean Population

Noninfectious uveitis in the Asia–Pacific region

Phenotype heterogeneity in Late-onset Behçet’s syndrome: A cohort from a referral center in China

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